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Systematic Review of Available Guidelines on Fertility Preservation of Young Patients with Breast Cancer

  • Haddadi, Mahnaz (Cancer Models Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences) ;
  • Muhammadnejad, Samad (Research Center for Molecular and Cellular Imaging) ;
  • Sadeghi-Fazel, Fariba (Health Management Department, Quality Assurance Deputy, Razi Vaccine & Serum Research Institute) ;
  • Zandieh, Zahra (Anatomy Department, School of Medicine, Iran University of Medical Sciences) ;
  • Rahimi, Gohar (Research Group for Reproductive Medicine and IVF-Laboratory, Department of Obstetrics and Gynecology, Cologne University) ;
  • Sadighi, Sanambar (Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences) ;
  • Akbari, Parya (School of Medicine, Tehran University of Medical Sciences) ;
  • Mohagheghi, Mohammad-Ali (Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences) ;
  • Mosavi-Jarrahi, Alireza (Cancer Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences) ;
  • Amanpour, Saeid (Cancer Models Research Center, Cancer Institute of Iran, Tehran University of Medical Sciences)
  • Published : 2015.03.04

Abstract

Background: Since the survival rate of breast cancer patients has improved, harmful effects of new treatment modalities on fertility of the young breast cancer patients has become a focus of attention. This study aimed to systematically review and critically appraise all available guidelines for fertility preservation in young breast cancer patients. Materials and Methods: Major citation databases were searched for treatment guidelines. Experts from relevant disciplines appraised the available guidelines. The AGREE II Instrument that includes 23 criteria in seven domains (scope and purpose of the guidelines, stakeholder involvement, rigor of development, clarity, applicability, editorial independence, and overall quality) was used to apprise and score the guidelines. Results: The search strategy retrieved 2,606 citations; 72 were considered for full-text screening and seven guidelines were included in the study. There was variability in the scores assigned to different domains among the guidelines. ASCO (2013), with an overall score of 68.0%, had the highest score, and St Gallen, with an overall score of 24.7%, had the lowest scores among the guidelines. Conclusions: With the promising survival rate among breast cancer patients, more attention should be given to include specific fertility preservation recommendations for young breast cancer patients.

Keywords

References

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