Anxiety and mood (대한불안의학회지)

Korean Academy of Anxiety Disorders (대한불안의학회)
권호 표지

Impaired Response Inhibition in Patients with Obsessive-Compulsive Disorder

강박장애 환자의 반응억제 결함

  • Boo, Young Jun (Department of Medicine, Yonsei University College of Medicine) ;
  • Kim, Se Joo (Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine) ;
  • Kang, Jee In (Department of Psychiatry and Institute of Behavioral Science in Medicine, Yonsei University College of Medicine)
  • 부영준 (연세대학교 의과대학 의학과) ;
  • 김세주 (연세대학교 의과대학 정신과학교실, 의학행동과학연구소) ;
  • 강지인 (연세대학교 의과대학 정신과학교실, 의학행동과학연구소)
  • Received : 2015.02.09
  • Accepted : 2015.04.02
  • Published : 2015.04.30
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Abstract

Objective : Impaired response inhibition has been suggested to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibition in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with commission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contribute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in patients with OCD.

Keywords

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