Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Semi-Quantitative Exposure Assessment of Occupational Exposure to Wood Dust and Nasopharyngeal Cancer Risk

  • Ekpanyaskul, Chatchai (Department of Preventive and Social Medicine, Faculty of Medicine, Srinakharinwirot University) ;
  • Sangrajrang, Suleeporn (Research Division, National Cancer Institute) ;
  • Ekburanawat, Wiwat (Occupational and Environmental Medicine Center, Nopparat Rajthanee Hospital) ;
  • Brennan, Paul (International Agency for Research on Cancer) ;
  • Mannetje, Andrea (Centre for Public Health Research, Massey University) ;
  • Thetkathuek, Anamai (Department of Industrial Hygiene and Safety, Faculty of Public Heath, Burapha University) ;
  • Saejiw, Nutjaree (School of Allied Health Science and Public Health, Walailak University) ;
  • Ruangsuwan, Tassanu (Department of Safety Engineering, Faculty of Engineering, South-east Asia University Bangkok) ;
  • Boffetta, Paolo (Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai)
  • Published : 2015.06.03
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Abstract

Occupational exposure to wood dust is one cause of nasopharyngeal cancer (NPC); however, assessing this exposure remains problematic. Therefore, the objective of this study was to develop a semi-quantitative exposure assessment method and then utilize it to evaluate the association between occupational exposure to wood dust and the development of NPC. In addition, variations in risk by histology were examined. A case-control study was conducted with 327 newly diagnosed cases of NPC at the National Cancer Institute and regional cancer centers in Thailand with 1:1 controls matched for age, gender and geographical residence. Occupational information was obtained through personal interviews. The potential probability, frequency and intensity of exposure to wood dust were assessed on a job-by-job basis by experienced experts. Analysis was performed by conditional logistic regression and presented in odds ratio (ORs) estimates and 95% confidence intervals (CI). Overall, a non significant relationship between occupational wood dust exposure and NPC risk for all subjects was observed (ORs=1.61, 95%CI 0.99-2.59); however, the risk became significant when analyses focused on types 2 and 3 of NPC (ORs=1.62, 95%CI 1.03-2.74). The significant association was stronger for those exposed to wood dust for > 10 year (ORs=2.26, 95%CI 1.10-4.63), for those with first-time exposure at age > 25 year (ORs=2.07, 95%CI 1.08-3.94), and for those who had a high cumulative exposure (ORs=2.17, 95%CI 1.03-4.58) when compared with those considered unexposed. In conclusion, wood dust is likely to be associated with an increased risk of type 2 or 3 NPC in the Thai population. The results of this study show that semi-quantitative exposure assessment is suitable for occupational exposure assessment in a case control study and complements the information from self-reporting.

Keywords

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