DOI QR코드

DOI QR Code

G894T and 4a/b Polymorphisms of NOS3 Gene are Not Associated with Cancer Risk: a Meta-analysis

  • Haque, Shafiul (Department of Biosciences, Jamia Millia Islamia (A Central University)) ;
  • Mandal, Raju K (Research and Scientific Studies Unit, College of Nursing and Allied Health Sciences, Jazan University) ;
  • Akhter, Naseem (Department of Laboratory Medicine, Faculty of Applied Medical Sciences, Albaha University) ;
  • Panda, Aditya K (Centre for Life Science, School of Natural Sciences, Central University of Jharkhand) ;
  • Hussain, Arif (School of Life Sciences, Manipal University) ;
  • Khan, Saif (Department of Clinical Nutrition, College of Applied Medical Sciences, University of Ha'il) ;
  • Lohani, Mohtashim (Department of Biosciences, Integral University)
  • 발행 : 2015.04.14

초록

Endothelial nitric oxide synthase (eNOS or NOS3) produces nitric oxide and genetic polymorphisms of NOS3 gene play significant roles in various processes of carcinogenesis. The results from published studies on the association between NOS3 G894T and NOS3 intron 4 (4a/b) polymorphisms and cancer risk are conflicting and inconclusive. However, i n order to assess this relationship more precisely, a meta-analysis was performed with PubMed (Medline), EMBASE and Google web searches until February 2014 to select all published case-control and cohort studies. Genotype distribution data were collected to calculate the pooled odd ratios (ORs) and 95% confidence intervals (CIs) to evaluate the strength of association. A total of 10,546 cancer cases and 10,550 controls were included from twenty four case-control studies for the NOS3 G894T polymorphism. The results indicated no significant association with cancer risk as observed in allelic (T vs G: OR=1.024, 95%CI=0.954 to 1.099, p=0.508), homozygous (TT vs GG: OR=1.137, 95%CI=0.944 to 1.370, p=0.176), heterozygous (GT vs GG: OR=0.993, 95%CI=0.932 to 1.059, p=0.835), recessive (TT vs GG+GT: OR=1.100, 95%CI=0.936 to 1.293, p=0.249) and dominant (TT+GT vs GG: OR=1.012, 95%CI=0.927 to 1.105, p=0.789) genetic models. Similarly, a total of 3,449 cancer cases and 3,691 controls were recruited from fourteen case-control studies for NOS3 4a/b polymorphism. Pooled results indicated no significant association under allelic (A vs B: OR=0.981, 95%CI=0.725 to 1.329, p=0.902), homozygous (AA vs BB: OR=1.166, 95%CI=0.524 to 2.593, p=0.707), heterozygous (BA vs BB: OR=1.129, 95%CI=0.896 to 1.422, p=0.305), dominant (AA+BA vs BB: OR=1.046, 95%CI=0.779 to 1.405, p=0.763) and recessive (AA vs BB+BA: OR=1.196, 95%CI=0.587 to 2.439, p=0.622) genetic contrast models. This meta-analysis suggests that G894T and 4a/b polymorphisms of NOS3 gene are not associated with increased or decreased risk of overall cancer.

키워드

참고문헌

  1. Amasyali AS, Kucukgergin C, Erdem S, et al (2012). Nitric oxide synthase (eNOS4a/b) gene polymorphism is associated with tumor recurrence and progression in superficial bladder cancer cases. J Urol, 188, 2398-403. https://doi.org/10.1016/j.juro.2012.07.096
  2. Arikan S, Cacina C, Guler E, G, et al (2012). The effects of NOS3 Glu298Asp variant on colorectal cancer risk and progression in Turkish population. Mol Biol Rep, 39, 3245-9. https://doi.org/10.1007/s11033-011-1092-8
  3. Brankovic A, Brajuskovic G, Nikolic Z, et al (2013). Endothelial nitric oxide synthase gene polymorphisms and prostate cancer risk in Serbian population. Int J Exp Pathol, 94, 355-61. https://doi.org/10.1111/iep.12045
  4. Burton PR, Hansell AL, Fortier I, et al (2009). Size matters: just how big is BIG?: Quantifying realistic sample size requirements for human genome epidemiology. Int J Epidemiol, 38, 263-73. https://doi.org/10.1093/ije/dyn147
  5. Chen Y, Li J, Guo Y et al. (2014). Nitric oxide synthase 3 gene variants and colorectal cancer: a meta-analysis. Asian Pac J Cancer Prev, 15, 3811-5. https://doi.org/10.7314/APJCP.2014.15.8.3811
  6. Chien YH, Bau DT, Jan KY (2004). Nitric oxide inhibits DNAadduct excision in nucleotide excision repair. Free Radic Biol Med, 36, 1011-7. https://doi.org/10.1016/j.freeradbiomed.2004.01.011
  7. Cimponeriu D, Ion DA, Spandole1 S, et al (2013). Potential implication of genetic polymorphisms and Torque teno virus in poradic breast cancer. Romanian Biotechnological Letters, 18, 7889-96.
  8. Cohn LD, Becker BJ (2002). How meta-analysis increases statistical power. Psychol Methods, 3, 243-53.
  9. Conde MC, Ramirez-Lorca R, Lopez-Jamar JM, et al (2006). Genetic analysis of caveolin-1 and eNOS genes in colorectal cancer. Oncol Rep, 16, 353-9.
  10. DerSimonian R, Laird N (1986). Meta-analysis in clinical trials. Control Clin Trials, 7, 177-188. https://doi.org/10.1016/0197-2456(86)90046-2
  11. Dimitrov Y, Petitjean P, Hannedouche T (1997) Kidney and nitric oxide. Nephrologie, 18, 41-46.
  12. Egger M, Davey-Smith G, Schneider M, Minder C (1997). Bias in meta-analysis detected by a simple, graphical test. BMJ, 7109, 629-34.
  13. Forstermann U, Boissel JP, Kleinert H (1998). Expressional control of the 'constitutive' isoforms of nitric oxide synthase (NOS I and NOS III). FASEB J, 12, 773-90.
  14. Fu H, Zhang Y, Jin L, Ding Z (2011). Endothelial nitric oxide synthase (eNOS) G894T polymorphism is not associated with breast cancer risk: new evidence. Breast Cancer Res Treat, 128, 595-8. https://doi.org/10.1007/s10549-011-1438-x
  15. Fujita S, Masago K, Hatachi Y, et al (2010). Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy. BMC Med Genet, 11, 167. https://doi.org/10.1186/1471-2350-11-167
  16. Fukumura D, Kashiwagi S, Jain RK (2006). The role of nitric oxide in tumour progression. Nat Rev Cancer, 6, 521-534. https://doi.org/10.1038/nrc1910
  17. Garban HJ, Bonavida B (1999). Nitric oxide sensitizes ovarian tumor cells to Fas-induced apoptosis. Gynecol Oncol, 73, 257-64. https://doi.org/10.1006/gyno.1999.5374
  18. Ghilardi G, Biondi ML, Cecchini F, et al (2003). Vascular invasion in human breast cancer is correlated to T-->786C polymorphism of NOS3 gene. Nitric Oxide, 9, 118-122. https://doi.org/10.1016/j.niox.2003.09.002
  19. Hao Y, Montiel R, Huang Y (2010). Endothelial nitric oxide synthase (eNOS) 894 G>T polymorphism is associated with breast cancer risk: a meta-analysis. Breast Cancer Res Treat, 124, 809-813. https://doi.org/10.1007/s10549-010-0833-z
  20. Hefler LA, Grimm C, Lantzsch T, et al (2006). Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer. Breast Cancer Res Treat, 98, 151-5. https://doi.org/10.1007/s10549-005-9143-2
  21. Hefler LA, Ludwig E, Lampe D, et al (2002). Polymorphisms of the endothelial nitric oxide synthase gene in ovarian cancer. Gynecol Oncol, 86, 134-7. https://doi.org/10.1006/gyno.2002.6749
  22. Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003). Measuring inconsistency in meta-analyses. BMJ, 7414, 557-60.
  23. Hindorff LA, Sethupathy P, Junkins HA, et al (2009). Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. Proc Natl Acad Sci USA, 106, 9362-7.
  24. Ioannidis JP, Ntzani EE, Trikalinos TA, Contopoulos-Ioannidis DG (2001). Replication validity of genetic association studies. Nat Genet, 29, 306-9. https://doi.org/10.1038/ng749
  25. Jacobs EJ, Hsing AW, Bain EB, et al (2008). Polymorphisms in angiogenesis-related genes and prostate cancer. Cancer Epidemiol Biomarkers Prev, 17, 972-7. https://doi.org/10.1158/1055-9965.EPI-07-2787
  26. Jang MJ, Jeon YJ, Kim JW, et al (2013). Association of eNOS polymorphisms (-786T>C, 4a4b, 894G>T) with colorectal cancer susceptibility in the Korean population. Gene, 512, 275-81. https://doi.org/10.1016/j.gene.2012.10.032
  27. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
  28. Kong L, Dunn GD, Keefer LK, Korthuis RJ (1996). Nitric oxide reduces tumor cell adhesion to isolated rat postcapillary venules. Clin Exp Metastasis, 14, 335-43. https://doi.org/10.1007/BF00123392
  29. Lala PK, Orucevic A (1998). Role of nitric oxide in tumor progression: lessons from experimental tumors. Cancer Metastasis Rev, 17, 91-106. https://doi.org/10.1023/A:1005960822365
  30. Lee KM, Choi JY, Lee JE, et al (2007). Genetic polymorphisms of NOS3 are associated with the risk of invasive breast cancer with lymph node involvement. Breast Cancer Res Treat, 106, 433-438. https://doi.org/10.1007/s10549-007-9506-y
  31. Lee KM, Kang D, Park SK, et al (2009). Nitric oxide synthase gene polymorphisms and prostate cancer risk. Carcinogenesis, 30, 621-5. https://doi.org/10.1093/carcin/bgp028
  32. Lee SA, Lee KM, Yoo KY, et al (2012). Combined effects of antioxidant vitamin and NOS3 genetic polymorphisms on breast cancer risk in women. Clin Nutr, 31, 93-98. https://doi.org/10.1016/j.clnu.2011.08.005
  33. Li Y, Ambrosone CB, McCullough MJ, et al (2009). Oxidative stress-related genotypes, fruit and vegetable consumption and breast cancer risk. Carcinogenesis, 30, 777-784. https://doi.org/10.1093/carcin/bgp053
  34. Lichtenstein P, Holm NV, Verkasalo PK, et al (2000). Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med, 343, 78-85. https://doi.org/10.1056/NEJM200007133430201
  35. Lu J, Wei Q, Bondy ML, et al (2006). Promoter polymorphism (-786t>C) in the endothelial nitric oxide synthase gene is associated with risk of sporadic breast cancer in non- Hispanic white women age younger than 55 years. Cancer, 107, 2245-53. https://doi.org/10.1002/cncr.22269
  36. Mandal RK, Yadav SS, Panda AK (2014). Meta-analysis on the association of nucleotide excision repair gene XPD A751C variant and cancer susceptibility among Indian population. Mol Biol Rep, 41, 713-9. https://doi.org/10.1007/s11033-013-2910-y
  37. Mantel N, Haenszel W (1959). Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst, 4, 719-48.
  38. Medeiros R, Morais A, Vasconcelos A, et al (2002). Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer. Eur J Cancer Prev, 11, 343-50. https://doi.org/10.1097/00008469-200208000-00005
  39. Moncada S, Palmer RM, Higgs EA (1991). Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev, 43, 109-42.
  40. Nicolson GL (1989). Organ specificity of tumor metastasis: role of preferential adhesion, invasion and growth of malignant cells at specific secondary sites. Cancer Metastasis Rev, 7, 143-8.
  41. Ozturk E, Dikensoy E, Balat O, et al (2011). Association of endothelial nitric oxide synthase gene polymorphisms with endometrial carcinoma: a preliminary study. J Turkish- German Gynecol Assoc, 12, 229-33.
  42. Pharoah PD, Dunning AM, Ponder BA, Easton DF (2004). Association studies for finding cancer-susceptibility genetic variants. Nat Rev Cancer, 4, 850-60. https://doi.org/10.1038/nrc1476
  43. Ramirez-Patino R, Figuera LE, Puebla-Perez AM, et al (2013). Intron 4 VNTR (4a/b) polymorphism of the endothelial nitric oxide synthase gene is associated with breast cancer in Mexican women. J Korean Med Sci, 28, 1587-94. https://doi.org/10.3346/jkms.2013.28.11.1587
  44. Riener EK, Hefler LA, Grimm C, et al (2004). Polymorphisms of the endothelial nitric oxide synthase gene in women with vulvar cancer. Gynecol Oncol, 93, 686-690. https://doi.org/10.1016/j.ygyno.2004.03.030
  45. Royo JL, Moreno-Nogueira JA, Galan JJ, et al (2006). Lack of association between NOS3 Glu298Asp and breast cancer risk: a case-control study. Breast Cancer Res Treat, 100, 331-3. https://doi.org/10.1007/s10549-006-9258-0
  46. Ryk C, Wiklund NP, Nyberg T, de Verdier PJ (2011). Polymorphisms in nitric-oxide synthase 3 may influence the risk of urinary-bladder cancer. Nitric Oxide, 25, 338-43. https://doi.org/10.1016/j.niox.2011.06.003
  47. Safarinejad MR, Safarinejad S, Shafiei N, Safarinejad S (2013). Effects of the T-786C, G894T, and Intron 4 VNTR (4a/b) polymorphisms of the endothelial nitric oxide synthase gene on the risk of prostate cancer. Urol Oncol, 31, 1132-1140. https://doi.org/10.1016/j.urolonc.2012.01.002
  48. Schmidt HH, Walter U (1994). NO at work. Cell, 78, 919-25.
  49. Shi Q, Xiong Q, Wang B, et al (2000). Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis. Cancer Res, 60, 2579-83.
  50. Tecder Unal M, Karabulut HG, Gumus-Akay G, et al (2010). Endothelial nitric oxide synthase gene polymorphism in gastric cancer. Turk J Gastroenterol, 21, 338-44. https://doi.org/10.4318/tjg.2010.0118
  51. Umansky V, Bucur M, Schirrmacher V, Rocha M (1997). Activated endothelial cells induce apoptosis in lymphoma cells. Int J Oncol, 10, 465-71.
  52. Veldman BA, Spiering W, Doevendans PA, et al (2002). The Glu298Asp polymorphism of the NOS3 gene as a determinant of the baseline production of nitric oxide. J Hypertens, 20, 2023-7. https://doi.org/10.1097/00004872-200210000-00022
  53. Verim L, Toptas B, Ozkan NE, et al (2013). Possible relation between the NOS3 gene GLU298ASP polymorphism and bladder cancer in Turkey. Asian Pac J Cancer Prev, 14, 665-668. https://doi.org/10.7314/APJCP.2013.14.2.665
  54. Wang XL, Mahaney MC, Sim AS, et al (1997). Genetic contribution of the endothelial constitutive nitric oxide synthase gene to plasma nitric oxide levels. Arterioscler Thromb Vasc Biol, 17, 3147-53. https://doi.org/10.1161/01.ATV.17.11.3147
  55. Wink DA, Hanbauer I, Grisham MB, et al (1996). Chemical biology of nitric oxide: regulation and protective and toxic mechanisms. Current Top Cell Regul, 34, 159-87. https://doi.org/10.1016/S0070-2137(96)80006-9
  56. Woolf B (1955). On estimating the relation between blood group and disease. Ann Hum Genet, 19, 251-3. https://doi.org/10.1111/j.1469-1809.1955.tb01348.x
  57. Wu R, Li B (1999). A multiplicative-epistatic model for analyzing interspecific differences in outcrossing species. Biometrics, 2, 355-65.
  58. Xu W, Charles IG, Moncada S, et al (1994). Mapping of the genes encoding human inducible and endothelial nitric oxide synthase (NOS2 and NOS3) to the pericentric region of chromosome 17 and to chromosome 7, respectively. Genomics, 21, 419-422. https://doi.org/10.1006/geno.1994.1286
  59. Yang J, Ambrosone CB, Hong CC, et al (2007). Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis, 28, 1247-53. https://doi.org/10.1093/carcin/bgm016
  60. Yeh CC, Santella RM, Hsieh LL, Sung FC, Tang R (2009). An intron 4 VNTR polymorphism of the endothelial nitric oxide synthase gene is associated with early-onset colorectal cancer. Int J Cancer, 124, 1565-71. https://doi.org/10.1002/ijc.24114
  61. Ying L, Hofseth LJ (2007). An emerging role for endothelial nitric oxide synthase in chronic inflammation and cancer. Cancer Res, 67, 1407-10. https://doi.org/10.1158/0008-5472.CAN-06-2149
  62. Yuan F, Zhang LS, Li HY, et al (2013). Influence of angiotensin I-converting enzyme gene polymorphism on hepatocellular carcinoma risk in China. DNA Cell Biol, 32, 268-73. https://doi.org/10.1089/dna.2012.1910
  63. Zhao P, Zhao L, Zou P, et al (2012). Genetic oxidative stress variants and glioma risk in a Chinese population: a hospitalbased case-control study. BMC Cancer, 12, 617. https://doi.org/10.1186/1471-2407-12-617
  64. Zintzaras E, Grammatikou M, Kitsios GD, et al (2010). Polymorphisms of the endothelial nitric oxide synthase gene in breast cancer: a genetic association study and metaanalysis. J Hum Genet, 55, 743-8. https://doi.org/10.1038/jhg.2010.100

피인용 문헌

  1. Relation between Endothelial Nitric Oxide Synthase Genotypes and Oxidative Stress Markers in Larynx Cancer vol.2016, pp.1942-0994, 2016, https://doi.org/10.1155/2016/4985063
  2. Association Between 12 Polymorphisms of VEGF/Hypoxia/Angiogenesis Pathway Genes and Risk of Urogenital Carcinomas: A Meta-Analysis Based on Case-Control Studies vol.9, pp.1664-042X, 2018, https://doi.org/10.3389/fphys.2018.00715
  3. Role of ESR Pathway Genes in Breast Cancer: A Review vol.07, pp.02, 2018, https://doi.org/10.4236/abcr.2018.72010