DOI QR코드

DOI QR Code

RASSF1A Gene Methylation is Associated with Nasopharyngeal Carcinoma Risk in Chinese

  • Wu, Kun (Medical Faculty, Kunming University of Science and Technology) ;
  • Xu, Xiao-Ning (Clinical psychology department, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Chen, Yu (Medical Faculty, Kunming University of Science and Technology) ;
  • Pu, Xiao-Lin (Medical Faculty, Kunming University of Science and Technology) ;
  • Wang, Bo-Yuan (Digestive system department, the First People's Hospital of Yunnan Province, Panlong Campus) ;
  • Tang, Xiao-Dan (Medical Faculty, Kunming University of Science and Technology)
  • 발행 : 2015.04.03

초록

In order to explore the association between RASSF1A methylation and nasopharyngeal carcinoma (NPC) risk of Chinese, we carried out a meta-analysis with searches of PubMed, Web of Science, ProQest and Medline databases. Ultimately, 14 articles were identified and analysised using R Software (R version 3.1.2) including meta packages. Overall, we found a significant relationship between RASSF1A methylation and NPC risk (OR 30.7; 95 % CI, 16.71~56.23; z=11.0591; p<0.0001) in a fixed effects model and (OR 32.1; 95% CI, 14.27~72.01; z=8.3984; p<0.0001) in a random effects model pooled. In tissue and NP brushings groups, similar results were found. Hence, our study identified a strong association between RASSF1A methylation and NPC and highlighted a promising potential for RASSF1A methylation in NPC risk prediction of Chinese.

키워드

참고문헌

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피인용 문헌

  1. HPV16 oncogenes E6 or/and E7 may influence the methylation status of RASSFIA gene promoter region in cervical cancer cell line HT-3 vol.37, pp.4, 2017, https://doi.org/10.3892/or.2017.5465