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Nested Case-control Study of Occupational Radiation Exposure and Breast and Esophagus Cancer Risk among Medical Diagnostic X Ray Workers in Jiangsu of China

  • Wang, Fu-Ru (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Fang, Qiao-Qiao (Department of Respiratory Medicine, Nanjing Children's Hospital Affiliated to Nanjing Medical University) ;
  • Tang, Wei-Ming (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Xu, Xiao-San (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Mahapatra, Tanmay (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Mahapatra, Sanchita (Department of Epidemiology, Fielding School of Public Health, University of California) ;
  • Liu, Yu-Fei (National Institute for Radiological Protection) ;
  • Yu, Ning-Le (Department of Radiation protection, JiangSu Provincial Center for Disease Prevention and Control) ;
  • Sun, Quan-Fu (National Institute for Radiological Protection)
  • 발행 : 2015.06.26

초록

Medical diagnostic X-ray workers are one occupational group that expose to the long-term low-dose external radiation over their working lifetime, and they may under risk of different cancers. This study aims to determine the relationship between the occupational X-ray radiation exposure and cancer risk among these workers in Jiangsu, China. We conducted Nested case-control study to investigate the occupational X-ray radiation exposure and cancer risk. Data were collected through self-administered questionnaire, which includes but not limits to demographic data, personal behaviors and family history of cancer. Retrospective dose reconstruction was conducted to estimate the cumulative doses of the x-ray workers. Inferential statistics, t-test and 2 tests were used to compare the differences between each group. We used the logistic regression model to calculate the odds ratio (OR) and 95% confidence interval (CI) of cancer by adjusting the age, gender. All 34 breast cancer cases and 45 esophageal cancer cases that detected in a cohort conducted among health workers between 1950~2011 were included in this presented study, and 158 cancer-free controls were selected by frequency-matched (1:2). Our study found that the occupational radiation exposure was associated with a significantly increased cancer risk compared with the control, especially in breast cancer and esophageal cancer (adjusted OR=2.90, 95% CI: 1.19-7.04 for breast cancer; OR=4.19, 95% CI: 1.87-9.38 for esophageal cancer, and OR=3.43, 95% CI: 1.92-6.12 for total cancer, respectively). The occupational X-ray radiation exposure was associated with increasing cancer risk, which indicates that proper intervention and prevention strategies may be needed in order to bring down the occupational cancer risk.

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참고문헌

  1. Andersson M, Engholm G, Ennow K, Jessen KA, Storm HH (1991). Cancer risk among staff at two radiotherapy departments in Denmark. Br J Radiol, 64, 455-60. https://doi.org/10.1259/0007-1285-64-761-455
  2. Bellini MF, Cadamuro AC, Succi M, Proenca MA, Silva AE (2012). Alterations of the TP53 gene in gastric and esophageal carcinogenesis. J Biomed Biotechnol, 2012, 891961.
  3. Boice JD Jr, Preston D, Davis FG, Monson RR (1991). Frequent chest X-ray fluoroscopy and breast cancer incidence among tuberculosis patients in Massachusetts. Radiat Res, 125, 214-22. https://doi.org/10.2307/3577890
  4. Charles M (2001). UNSCEAR report 2000: sources and effects of ionizing radiation. United Nations Scientific Comittee on the Effects of Atomic Radiation. J Radiol Prot, 21, 83-6. https://doi.org/10.1088/0952-4746/21/1/609
  5. Doll, R (2005). Mortality of british radiologists: a lecture note. J Radiat Res, 46, 123-9. https://doi.org/10.1269/jrr.46.123
  6. Hamdan S, Morse B, Reinhold D (1999). Nickel subsulfide is similar to potassium dichromate in protecting normal human fibroblasts from the mutagenic effects of benzo[a]pyrene diolepoxide. Environ Mol Mutagen, 33, 211-8. https://doi.org/10.1002/(SICI)1098-2280(1999)33:3<211::AID-EM5>3.0.CO;2-7
  7. Hattori A, Kunz HW, Gill TJ 3rd, Pan SF, Shinozuka H (1988). Diversity of the promoting action of cyclosporine on the induction of murine lymphoid tumors. Carcinogenesis, 9, 1091-4. https://doi.org/10.1093/carcin/9.6.1091
  8. Helleday T, Nilsson R, Jenssen D (2000). Arsenic[III] and heavy metal ions induce intrachromosomal homologous recombination in the hprt gene of V79 Chinese hamster cells. Environ Mol Mutagen, 35, 114-22. https://doi.org/10.1002/(SICI)1098-2280(2000)35:2<114::AID-EM6>3.0.CO;2-Q
  9. Howe GR, McLaughlin J (1996). Breast cancer mortality between 1950 and 1987 after exposure to fractionated moderate-dose-rate ionizing radiation in the Canadian fluoroscopy cohort study and a comparison with breast cancer mortality in the atomic bomb survivors study. Radiat Res, 145, 694-707. https://doi.org/10.2307/3579360
  10. Little MP, Boice JD Jr (1999). Comparison of breast cancer incidence in the Massachusetts tuberculosis fluoroscopy cohort and in the Japanese atomic bomb survivors. Radiat Res, 151, 218-24. https://doi.org/10.2307/3579773
  11. Little MP, Kwon D, Doi K, et al (2014). Association of chromosome translocation rate with low dose occupational radiation exposures in U.S. radiologic technologists. Radiat Res, 182, 1-17. https://doi.org/10.1667/RR13413.1
  12. Liu Y, Cortopassi G, Steingrimsdottir H, et al (1997). Correlated mutagenesis of bcl2 and hprt loci in blood lymphocytes. Environ Mol Mutagen, 29, 36-45. https://doi.org/10.1002/(SICI)1098-2280(1997)29:1<36::AID-EM5>3.0.CO;2-B
  13. Matanoski GM, Tonascia JA, Correa-Villasenor A, et al (2008). Cancer risks and low-level radiation in U.S. shipyard workers. J Radiat Res, 49, 83-91. https://doi.org/10.1269/jrr.06082
  14. Moskowitz CS, Chou JF, Wolden SL, et al (2014). Breast cancer after chest radiation therapy for childhood cancer. J Clin Oncol, 32, 2217-23. https://doi.org/10.1200/JCO.2013.54.4601
  15. Murray S, Briasoulis E, Linardou H, et al (2012). Taxane resistance in breast cancer: mechanisms, predictive biomarkers and circumvention strategies. Cancer Treat Rev, 38, 890-903. https://doi.org/10.1016/j.ctrv.2012.02.011
  16. Nicklas JA, O'Neill JP, Hunter TC, et al (1991). In vivo ionizing irradiations produce deletions in the hprt gene of human T-lymphocytes. Mutat Res, 250, 383-96. https://doi.org/10.1016/0027-5107(91)90195-T
  17. Nishimura M, Wakana S, Kakinuma S, et al (1999). Low frequency of Ras gene mutation in spontaneous and gamma-ray-induced thymic lymphomas of scid mice. Radiat Res, 151, 142-9. https://doi.org/10.2307/3579764
  18. Phillips EN, Gebow D, Liber HL (1997). Spectra of X-ray-induced and spontaneous intragenic HPRT mutations in closely related human cells differentially expressing the p53 tumor suppressor gene. Radiat Res, 147, 138-47. https://doi.org/10.2307/3579414
  19. Saito Y, Ochiai Y, Kodama Y, et al (2001). Genetic loci controlling susceptibility to gamma-ray-induced thymic lymphoma. Oncogene, 20, 5243-7. https://doi.org/10.1038/sj.onc.1204675
  20. Shimizu Y1, Kato H, Schull WJ (1990). Studies of the mortality of A-bomb survivors. 9. Mortality, 1950-1985: Part 2. Cancer mortality based on the recently revised doses (DS86). Radiat Res, 121, 120-41. https://doi.org/10.2307/3577495
  21. Snijders AM, Marchetti F, Bhatnagar S, et al (2012). Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility. PLoS One, 7, 45394. https://doi.org/10.1371/journal.pone.0045394
  22. Sun SQ, Li SY, Yuan LY (1996). Radioepidemiological studies in the nuclear industry of China. Zhonghua Liu Xing Bing Xue Za Zhi, 17, 333-6.
  23. Thompson DE, Mabuchi K, Ron E, Soda M, et al (1994). Cancer incidence in atomic bomb survivors. Part II: Solid tumors, 1958-1987. Radiat Res, 137, 17-67. https://doi.org/10.2307/3578892
  24. Walerych D, Napoli M, Collavin L, Del Sal G (2012). The rebel angel: mutant p53 as the driving oncogene in breast cancer. Carcinogenesis, 33, 2007-17. https://doi.org/10.1093/carcin/bgs232
  25. Wang JX, Zhang LA, Li BX, et al (2002). Cancer incidence and risk estimation among medical x-ray workers in China, 1950-1995. Health Phys, 82, 455-66. https://doi.org/10.1097/00004032-200204000-00004
  26. Yoshida K, Inoue T, Nojima K, Hirabayashi Y, Sado T (1997). Calorie restriction reduces the incidence of myeloid leukemia induced by a single whole-body radiation in C3H/He mice. Proc Natl Acad Sci U S A, 94, 2615-9. https://doi.org/10.1073/pnas.94.6.2615
  27. Yoshinaga S, Aoyama T, Yoshimoto Y, Sugahara T (1999). Cancer mortality among radiological technologists in Japan: updated analysis of follow-up data from 1969 to 1993. J Epidemiol, 9, 61-72. https://doi.org/10.2188/jea.9.61
  28. Yoshinaga S, Mabuchi K, Sigurdson AJ, Doody MM, Ron E (2004). Cancer risks among radiologists and radiologic technologists: review of epidemiologic studies. Radiology, 233, 313-21. https://doi.org/10.1148/radiol.2332031119
  29. Yu Ningle, Wang Jin, Xu Cuizhen, Hu Lianzhi, Hou Bijun (2001). An epidemiologic investigation of cancers among medical diagnostic X-ray workers of 1950-1996 in Jiangsu Province. Chin J Radiol Med Prot, 21, 307-10. https://doi.org/10.1088/0952-4746/21/3/601
  30. Zeestraten EC, Benard A, Reimers MS, et al (2013). The prognostic value of the apoptosis pathway in colorectal cancer: a review of the literature on biomarkers identified by immunohistochemistry. Biomark Cancer, 5, 13-29.
  31. Zhang L, Jia D, Chang H, et al (1998). A retrospective dosimetry method for occupational dose for Chinese medical diagnostic x-ray workers. Radiation Protection Dosimetry, 77, 69-72. https://doi.org/10.1093/oxfordjournals.rpd.a032297
  32. Zimmer DM, Aaron CS (1997). In vivo mutagenesis in the cynomolgus monkey: time course of HPRT mutant frequency at long time points following ethylnitrosourea exposure. Environ Mol Mutagen, 29, 117-23. https://doi.org/10.1002/(SICI)1098-2280(1997)29:2<117::AID-EM2>3.0.CO;2-B

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