DOI QR코드

DOI QR Code

Radical Oncological Surgery and Adjuvan Therapy in Non-Small Cell Lung Cancer Patients over 70 years of Age

  • Demirci, Nilgun Yilmaz (Gazi University, Faculty of Medicine Chest Disease Department) ;
  • Ulger, Sukran (Gazi University, Medicine Radiation Oncology Department) ;
  • Yilmaz, Ulku (Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Chest Disease Clinic) ;
  • Aydogdu, Koray (Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Chest Disease Clinic) ;
  • Yilmaz, Aydin (Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Chest Disease Clinic) ;
  • Erdogan, Yurdanur (Ataturk Chest Diseases and Chest Surgery Training and Research Hospital, Chest Disease Clinic)
  • 발행 : 2015.06.26

초록

Background: The incidence of lung cancer increases with age. Approximately 50% of non-small cell lung cancer (NSCLC) patients are over 70 years old. Because of the increasing elderly population, treatment approaches in this age group continue to be studied similar to groups of young people. Materials and Methods: In the current study, 26 patients who underwent radical surgery and adjuvan chemoradiation at Ataturk Chest Diseases and Chest Surgery Training and Research Hospital were evaluated retrospectively. Results: Of 21 patients (81%) were male and the average age was 74.4. Lobectomy was performed in 18 cases, pneumonectomy in 3, sleeve lobectomy in 3 and bilobectomy in 2. There was no perioperative or early period mortality. Overall survival was 24.5 months. Conclusions: From our study, lung cancer surgery and adjuvant therapy can be performed safely with low morbidity in the elderly.

키워드

참고문헌

  1. Bouchardy C, Fioretta G, Perrot MD, et al (1999). Determinant of long term survival after surgery for cancer of the lung: a population based study. Cancer, 86, 2229-37. https://doi.org/10.1002/(SICI)1097-0142(19991201)86:11<2229::AID-CNCR9>3.0.CO;2-K
  2. Brunelli A, Charloux A, Bolliger CT, et al (2009). European respiratory society and European society of thoracic surgeons joint task force on fitness for radical therapy. ERS/ESTS clinical guidelines on fitness for radical therapy in lung cancer patients (surgery and chemo-radiotherapy). Eur Respir J, 34, 17-41. https://doi.org/10.1183/09031936.00184308
  3. Burfeind WR Jr, Tong BC, O'Branski E, et al (2008). Quality of life outcomes are equivalent after lobectomy in the elderly. J Thorac Cardiovasc Surg, 136, 597-604. https://doi.org/10.1016/j.jtcvs.2008.02.093
  4. Dominguez-Ventura A, Cassivi SD, Allen MS, et al (2007). Lung cancer in octogenerians: factors affecting long-term survival following resection. Eur J Cardiothorac Surg, 32, 370-4. https://doi.org/10.1016/j.ejcts.2007.04.002
  5. Fruh M, Rolland E, Pignon JP, et al (2008). Pooled analysis of the effect of age on adjuvant cisplatin-based chemotherapy for completely resected non-small-cell lung cancer. J Clin Oncol, 26, 3573-81. https://doi.org/10.1200/JCO.2008.16.2727
  6. Gonzalez-Aragoneses F, Moreno-Mata N, Simon-Adiego C, et al (2009). Lung cancer surgery in the elderly. Crit Rev Oncol Hematol, 71, 266-71. https://doi.org/10.1016/j.critrevonc.2008.09.010
  7. Jaklitsch MT, Mery CM, Audisio RA (2003). The use of surgery to treat lung cancer in elderly patients. Lancet Oncol, 4, 463-71. https://doi.org/10.1016/S1470-2045(03)01165-3
  8. Jazieh AR, Hussain M, Howington JA, et al (2000). Prognostic factors in patients with surgically resected stages I and II non-small cell lung cancer. Ann Thorac Surg, 70, 1168-71. https://doi.org/10.1016/S0003-4975(00)01529-0
  9. Jemal A, Siegel R, Xu J, et al (2010). Cancer statistics, 2010. CA Cancer J Clin, 60, 277-300. https://doi.org/10.3322/caac.20073
  10. Kang KM, Jeong BK, Ha IB, et al (2012). Concurrent chemoradiotherapy for elderly patients with stage III non-small cell lung cancer. Radiat Oncol J, 30, 140-5. https://doi.org/10.3857/roj.2012.30.3.140
  11. Langer CJ (2011). Clinical evidence on the under treatment of older and poor performance patients who have advanced non-small cell lung cancer: is there a role for targeted therapy in these cohorts? Clin Lung Cancer, 12, 272-9. https://doi.org/10.1016/j.cllc.2011.02.001
  12. Le Chevalier T (2010). Adjuvant chemotherapy for resectable non-small cell lung cancer: where is it going? Ann Oncol, 21, 196-8.
  13. Maione P, Rossi A, Sacco PC, et al (2010). Treating advanced non-small cell lung cancer in the elderly. Ther Adv Med Oncol, 2, 251-60. https://doi.org/10.1177/1758834010366707
  14. Matsuoka H, Okada M, Sakamoto T, et al (2005). Complications and outcomes after pulmonary resection for cancer in patients 80 to 89 years of age. Eur J Cardiothorac Surg, 28, 380-3. https://doi.org/10.1016/j.ejcts.2005.06.010
  15. Mery CM, Pappas AN, Bueno R, et al (2005). Similar longterm survival of elderly patients with non-small cell lung cancer treated with lobectomy or wedge resection within the surveillance, epidemiology, and end results database. Chest, 128, 237-45. https://doi.org/10.1378/chest.128.1.237
  16. Mizushima Y, Noto H, Sugiyama S, et al (1997). Survival and prognosis after pneumonectomy for lung cancer in the elderly. Ann Thoracic Surg, 64, 193-8. https://doi.org/10.1016/S0003-4975(97)82827-5
  17. Mun M, Kohno T (2008). Video-assisted thoracic surgery for clinical stage I lung cancer in octogenarians. Ann Thoracic Surg, 85, 406-11. https://doi.org/10.1016/j.athoracsur.2007.10.057
  18. Okami J, Higashiyama M, Asamura H, et al (2009). Pulmonary resection in patients aged 80 years or over with clinical stage I non-small cell lung cancer: prognostic factors for over all survival and risk factors fo rpostoperative complications. J Thorac Oncol, 4, 1247-53. https://doi.org/10.1097/JTO.0b013e3181ae285d
  19. Oliaro A, Leo F, Filosso PL, et al (1999). Resection for bronchogenic carcinoma in the elderly. J Cardiovasc Surg, 40, 715-9.
  20. Pagni S, McKelvey A, Riordan C, et al (1998). Pulmonary resection for malignancy in the elderly: is age still a risk factor? Eur J Cardiothorac Surg, 14, 40-4. https://doi.org/10.1016/S1010-7940(98)00145-6
  21. Thomas P, Piraux M, Jacques LF, et al (1998). Clinical patterns and trends of outcome of elderly patients with bronchogenic carcinoma. Eur J Cardiothorac Surg, 13, 266-74. https://doi.org/10.1016/S1010-7940(98)00011-6
  22. Ulger S, Kizilarslanoglu MC, Kilic MK, et al (2015). Estimating radiation therapy toxicity and tolerability with comprehensive assessment parameters in geriatric cancer patients. Asian Pac J Cancer Prev, 16, 1965-9. https://doi.org/10.7314/APJCP.2015.16.5.1965