참고문헌
- Agrawal PK, Bansal MC, (1989). Flavonoid glycosides. in: C-13 NMR of flavonoids, agrawal PK (Ed.), elsevier, amesterdam, Oxford, New York, Tokyo, p. 283-355.
- Alam MN, Bristi NJ, Rafiquzzaman M (2013). Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi Pharm J, 21, 143-52. https://doi.org/10.1016/j.jsps.2012.05.002
- Al-Duais M, Muller L, Bohm V, et al (2009). Antioxidant capacity and total phenolics of cyphostemma digitatum before and after processing: use of different assays. Eur Food Res Technol. 228, 813-21. https://doi.org/10.1007/s00217-008-0994-8
- Amic D, Davidovic-Amic D, Beslo D, et al (2007). SAR and QSAR of the Antioxidant activity of flavonoids. Curr Med Chem, 14, 827-45. https://doi.org/10.2174/092986707780090954
- Atjanasuppat K, Wongkham W, Meepowpan P, et al (2009). In vitro screening for anthelmintic and antitumour activity of ethnomedicinal plants from Thailand. J Ethnopharmacol. 123, 475-82. https://doi.org/10.1016/j.jep.2009.03.010
- Bampidis VA, Robinson PH (2006). Citrus by-products as ruminant feeds: a review. Animal Feed Sci Technol, 128, 175-217. https://doi.org/10.1016/j.anifeedsci.2005.12.002
-
Barreca D, Bisignano C, Ginestra G, et al (2013). Polymethoxylated, c- and o-glycosyl flavonoids in tangelo (citrus reticulata
${\times}$ citrus paradisi) juice and their influence on antioxidant properties. Food Chem. 141, 1481-8 https://doi.org/10.1016/j.foodchem.2013.03.095 - Barros HR, Ferreira TA, Genovese MI, (2012). Antioxidant capacity and mineral content of pulp and peel from commercial cultivars of citrus from Brazil. Food Chem, 134, 1892-8. https://doi.org/10.1016/j.foodchem.2012.03.090
- Berridge MV, Herst PM, Tan AS, (2005). Tetrazolium dyes as tools in cell biology: New insights into their cellular reduction. Biotechnol Annu Rev, 11, 127-52. https://doi.org/10.1016/S1387-2656(05)11004-7
- Boik J, (2001). Natural compounds in cancer therapy. promising nontoxic antitumor agents from plants & other natural sources. princeton, minn, USA: oregon medical press; 1st edition.
- Charoensinphon N, Qiu P, Dong P, et al (2013). 5-demethyltangeretin inhibits human nonsmall cell lung cancer cell growth by inducing G2/M cell cycle arrest and apoptosis. Mol Nutr Food Res, 57, 2103-11. https://doi.org/10.1002/mnfr.201300136
- Chen C, Ono M, Takeshima M, et al (2014). Antiproliferative and apoptosis-inducing activity of nobiletin against three subtypes of human breast cancer cell lines. Anticancer Res. 34, 1785-92.
- Cicco N, Lanorte MT, Paraggio M, et al (2009). A reproducible, rapid and inexpensive Folin-Ciocalteu micro-method in determining phenolics of plant methanol extracts. Microchem J, 91, 107-10. https://doi.org/10.1016/j.microc.2008.08.011
- Constantinou C, Papas KA, Constantinou AI, (2009). Caspaseindependent pathways of programmed cell death: The unraveling of new targets of cancer therapy? Curr Cancer Drug Targets, 9, 717-28. https://doi.org/10.2174/156800909789271512
- Cragg GM, Grothaus PG, Newman DJ, (2009). Impact of natural products on developing new anti-cancer agents. Chem Rev, 109, 3012-43. https://doi.org/10.1021/cr900019j
- Dai J, Mumper RJ, (2010). Plant phenolics: extraction, analysis and their antioxidant and anticancer properties. Molecules, 15, 7313-52 https://doi.org/10.3390/molecules15107313
- Demir E, Kocaoglu S, Cetin H, et al (2009). Antigenotoxic effects of citrus aurentium l. fruit peel oil on mutagenicity of two alkylating agents and two metals in the drosophila wing spot test. Environ Mol Mutagen, 50, 483-8. https://doi.org/10.1002/em.20484
- Dong Y, Cao A, Shi J, et al (2014). Tangeretin, a citrus polymethoxyflavonoid, induces apoptosis of human gastric cancer AGS cells through extrinsic and intrinsic signaling pathways. Oncol Rep, 31, 1788-94.
- Elmore S, (2007). Apoptosis: a review of programmed cell death. Toxicol Pathol, 35, 495-516. https://doi.org/10.1080/01926230701320337
- FAO 2011: http://faostat.fao.org/site/339/default.aspx
- Garcia-Salas P, Morales-Soto A, Segura-Carretero A, et al (2010). Phenolic compound extraction systems for fruit and vegetable samples. Molecules, 15, 8813-26. https://doi.org/10.3390/molecules15128813
- Ghasemi K, Ghasemi Y, Ebrahimzadeh MA, (2009). Antioxidant activity, phenol and flavonoid contents of 13 citrus species peels and tissues. Pak J Pharm Sci, 22, 277-81.
-
Hamdan D, Ashour ML, Mulyaningsih S, et al (2013). Chemical composition of the essential oils of variegated pink-fleshed lemon (Citrus
${\times}$ limon L. Burm. f.) and their anti-inflammatory and antimicrobial activities. Z Naturforsch C, 68, 275-84. https://doi.org/10.5560/ZNC.2013.68c0275 - Harborne JB, (1973). Phytochemical methods, chapman and hall, Ltd., London, p. 49.
- Hegazy AE, Ibrahium MI, (2012). Antioxidant activities of orange peel extracts. World Appl Sci J, 18, 684-8.
- Heim KE, Tagliaferro AR, Bobilya DJ, (2002). Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships. J Nutr Biochem, 13, 572-84. https://doi.org/10.1016/S0955-2863(02)00208-5
- Herald TJ, Gadgil P, Tilley M, (2012). High-throughput microplate assays for screening flavonoid content and DPPHscavenging activity in sorghum bran and flour. J Sci Food Agric, 92, 2326-31. https://doi.org/10.1002/jsfa.5633
- Hosseinimehr SJ, Karami M, (2005). Citrus extract modulates genotoxicity induced by cyclophosphamide in mice bone marrow cells. J Pharm Pharmacol, 57, 505-9. https://doi.org/10.1211/0022357055849
- Hsiao PC, Lee WJ, Yang SF, et al (2014). Nobiletin suppresses the proliferation and induces apoptosis involving MAPKs and caspase-8/-9/-3 signals in human acute myeloid leukemia cells. Tumour Biol, 35, 11903-11. https://doi.org/10.1007/s13277-014-2457-0
- Im SJ, Kim JH, Kim MY, (2014). Evaluation of bioactive components and antioxidant and anticancer properties of citrus wastes generated during bioethanol production. Nat Prod Commun, 9, 483-6.
- Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90. https://doi.org/10.3322/caac.20107
- Jeong JM, Choi CH, Kang SK, et al. (2007). Antioxidant and chemosensitizing effects of flavonoids with hydroxy and/or methoxy groups and structure-activity relationship. J Pharm Pharm Sci, 10, 537-46.
- Justino GC, Rodrigues M, Florencio MH, et al. (2009). Structure and antioxidant activity of brominated flavonols and flavanones. J Mass Spectrom, 44, 1459-68. https://doi.org/10.1002/jms.1630
- Katiyar C, Gupta A, Kanjilal S, et al (2012). Drug discovery from plant sources: An integrated approach. Ayu, 33, 10-9. https://doi.org/10.4103/0974-8520.100295
- Kotz JC, Treichel PM, Townsend JR (2011). Chemistry and chemical reactivity. cengage learning, nelson education, Ltd, 8th, USA, p, 501.
- Lai CS, Li S, Miyauchi Y, et al. (2013). Potent anti-cancer effects of citrus peel flavonoids in human prostate xenograft tumors. Food Funct, 4, 944-9. https://doi.org/10.1039/c3fo60037h
- Lashkari S, Taghizadeh A, (2013). Nutrient digestibility and evaluation of protein and carbohydrate fractionation of citrus by-products. J Anim Physiol Anim Nutr (Berl), 97, 701-9. https://doi.org/10.1111/j.1439-0396.2012.01312.x
- Lewinska A, Siwak J, Rzeszutek I, et al (2015). Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line. Toxicol In Vitro, 3, 417-25.
- Li S, Pan MH, Lai CS, et al (2007). Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines. Bioorg Med Chem, 15, 3381-9. https://doi.org/10.1016/j.bmc.2007.03.021
- Markham KR, Geiger H, (1994). 1H nuclear magnetic resonance spectroscopy of flavonoids and their glycosides in hexadeuterodimethylsulfoxide. In: The Flavonoids :advances in research since 1986, harbone , j.b. (ed.), chapman and hall, London, united kingdom, p. 441- 497.
- National Cancer Institute (NCI). Surveillance, epidemiology, and end results program website. Available: http://seer.cancer.gov/statfacts/html/leuks.html. Accessed 2014 May 19.
- Nogata Y, Sakamoto K, Shiratsuchi H, et al (2006). Flavonoid composition of fruit tissues of citrus species. Biosci Biotechnol Biochem, 70, 178-92. https://doi.org/10.1271/bbb.70.178
- Oboh G, Ademosun AO, (2012). Characterization of the antioxidant properties of phenolic extracts from some citrus peels. J Food Sci Technol, 49, 729-36. https://doi.org/10.1007/s13197-010-0222-y
- Oliveira AM, Pinheiro LS, Pereira CK, et al (2012). Total phenolic content and antioxidant activity of some malvaceae family species. Antioxidants, 1, 33-43. https://doi.org/10.3390/antiox1010033
- Park JH, Lee M, Park E, (2014). Antioxidant activity of orange flesh and peel extracted with various solvents. Prev Nutr Food Sci, 19, 291-8. https://doi.org/10.3746/pnf.2014.19.4.291
- Park KI, Park HS, Nagappan A, et al (2012). Induction of the cell cycle arrest and apoptosis by flavonoids isolated from Korean Citrus aurantium L. in non-small-cell lung cancer cells. Food Chem, 135, 2728-35. https://doi.org/10.1016/j.foodchem.2012.06.097
- Petrie K, Zelent A, Waxman S, (2009). Differentiation therapy of acute myeloid leukemia: past, present and future. Curr Opin Hematol, 16, 84-91. https://doi.org/10.1097/MOH.0b013e3283257aee
- Pisoschi M, Cheregi MC, Danet AF, (2009). Total antioxidant capacity of some commercial fruit juices: electrochemical and spectrophotometrical approaches. Molecules, 14, 480-93. https://doi.org/10.3390/molecules14010480
- Rover MR, Brown RC, (2013). Quantification of total phenols in bio-oil using the folin-ciocalteu method. J Anal Appl Pyrol, 104, 366-71. https://doi.org/10.1016/j.jaap.2013.06.011
- Siles Lopez AJ, Li Q, Thompson IP, (2010). Biorefinery of waste orange peel. Crit Rev Biotechnol, 30, 63-9. https://doi.org/10.3109/07388550903425201
- Spigno G, Tramelli L, De Faveri DM, (2007). Effects of extraction time, temperature and solvent on concentration and antioxidant activity of grape marc phenolics. J Food Engin, 81, 200-8. https://doi.org/10.1016/j.jfoodeng.2006.10.021
- Sroka Z, Fecka I, Cisowski W, (2005). Antiradical and anti-H2O2 properties of polyphenolic compounds from an aqueous peppermint extract. Z Naturforsch C, 60, 826-32.
- Sultana S, Asif HM, Nazar HM, et al (2014). Medicinal plants combating against cancer--a green anticancer approach. Asian Pac J Cancer Prev, 15, 4385-94. https://doi.org/10.7314/APJCP.2014.15.11.4385
- Tan TW, Tsai HY, Chen YF, et al. (2004). Induction of apoptosis in human promyelocytic leukemia HL-60 cells by ampelopsis cantoniensis crude extract. In Vivo, 18, 457-62.
- Tripoli E, Guardia ML, Giammanco S, et al (2007). Citrus flavonoids: molecular structure, biological activity and nutritional properties: a review. Food Chem, 104, 466-79. https://doi.org/10.1016/j.foodchem.2006.11.054
- Wang S, Meckling KA, Marcone MF, et al (2011). Synergistic, additive, and antagonistic effects of food mixtures on total antioxidant capacities. J Agric Food Chem, 59, 960-8. https://doi.org/10.1021/jf1040977
- Weng CJ, Yen GC, (2012). Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities. Cancer Metastasis Rev, 31, 323-51. https://doi.org/10.1007/s10555-012-9347-y
- Wolfe KL, Liu RH, (2008). Structure-activity relationships of flavonoids in the cellular antioxidant activity assay. J Agric Food Chem, 56, 8404-11. https://doi.org/10.1021/jf8013074
- Woodman OL, Meeker WF, Boujaoude M, (2005). Vasorelaxant and antioxidant activity of flavonols and flavones: structureactivity relationships. J Cardiovasc Pharmacol, 46, 302-9. https://doi.org/10.1097/01.fjc.0000175431.62626.07
- Yang X, Kang SM, Jeon BT, (2011). Isolation and identification of an antioxidant flavonoid compound from citrus-processing by-product. J Sci Food Agric, 91, 1925-7. https://doi.org/10.1002/jsfa.4402
- Yoon JH, Lim TG, Lee KM, et al (2011). Tangeretin reduces ultraviolet B (UVB)-induced cyclooxygenase-2 expression in mouse epidermal cells by blocking mitogen-activated protein kinase (MAPK) activation and reactive oxygen species (ROS) generation. J Agric Food Chem, 59, 222-8. https://doi.org/10.1021/jf103204x
- Yumnam S, Park HS, Kim MK, et al (2014). Hesperidin induces paraptosis like cell death in hepatoblatoma, HepG2 cells: involvement of ERK1/2 MAPK. PLoS One, 9, 101321. https://doi.org/10.1371/journal.pone.0101321