Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Evaluation Frequency of Merkel Cell Polyoma, Epstein-Barr and Mouse Mammary Tumor Viruses in Patients with Breast Cancer in Kerman, Southeast of Iran

  • Reza, Malekpour Afshar (Kerman University of Medical sciences, Afzalipour School of Medicine, Research Center of Infectious and Tropical Diseases) ;
  • Reza, Mollaie Hamid (Medical Virology, Gastrointestinal and Liver Research center, Department of Medical Virology, Kerman University of Medical Sciences) ;
  • Mahdiyeh, Lashkarizadeh (Pathology and stem cell research center, Kerman University of Medical sciences) ;
  • Mehdi, Fazlalipour (Medical Virology, Department of Arboviruses, Institute of pasture) ;
  • Hamid, Zeinali Nejad (Kerman University of Medical sciences, Afzalipour School of Medicine, Department of Phisiology)
  • Published : 2015.11.04
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Abstract

Breast cancer is the most common cancer among women worldwide. Roles of the Epstein-Barr, Merkel cell polyoma and mouse mammary tumor viruses in breast carcinogenesis are still controversial although any relationship would clearly be important for breast cancer etiology, early detection and prevention. In the present study associations between EBV, MMTV and Merkel cell polyoma virus and breast cancer in 100 Iranian patients were evaluated using paraffin-embedded tissues. EBER RNA and expression of p53 and large T antigen were evaluated by real time PCR and CD34, p63, HER2, PR and ER markers were studied by immunohistochemistry. EBV was detected in 8/100 (8%), MMTV in 12/100 (12%), MPy in 3/100 (3%) and EBER RNA in 18/100 (18%) cases. None of the control samples demonstrated any of the viruses. p53 was suppressed in EBV, MPy and MMTV positive samples. The large T antigen rate was raised in MPy positive samples. Our results showed that EBV, MMTV and the Merkel cell polyoma virus are foundwith some proportion of breast cancers in our patients, suggesting that these viruses might have a significant role in breast cancer in Kerman, southeast of Iran.

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References

  1. Ahangar Oskouee M, Shahmahmoodi S, Jalilvand S, et al (2014). No evidence of mammary tumor virus env genelike sequences among Iranian women with breast cancer. Intervirol, 57, 353-6. https://doi.org/10.1159/000366280
  2. Antonsson A, Bialasiewicz S, Rockett RJ, et al (2012). Exploring the prevalence of ten polyomaviruses and two herpes viruses in breast cancer. PLoS One, 7, 39842. https://doi.org/10.1371/journal.pone.0039842
  3. Arbach H, Viglasky V, Lefeu F, et al (2006). Epstein-Barr virus (EBV) genome and expression in breast cancer tissue: effect of EBV infection of breast cancer cells on resistance to paclitaxel (Taxol). J Virol, 80, 845-53. https://doi.org/10.1128/JVI.80.2.845-853.2006
  4. Baltzell K, Buehring GC, Krishnamurthy S, et al (2012). Epstein- Barr virus is seldom found in mammary epithelium of breast cancer tissue using in situ molecular methods. Breast Cancer Res Treat, 132, 267-74. https://doi.org/10.1007/s10549-011-1841-3
  5. Ban KA, Godellas CV (2014). Epidemiology of breast cancer. Surg Oncol Clin N Am, 23, 409-22. https://doi.org/10.1016/j.soc.2014.03.011
  6. Bindra A, Muradrasoli S, Kisekka R, et al (2007). Search for DNA of exogenous mouse mammary tumor virus-related virus in human breast cancer samples. J Gen Virol, 88, 1806-9. https://doi.org/10.1099/vir.0.82767-0
  7. Corbex M, Bouzbid S, Traverse-Glehen A, et al (2014). Prevalence of papillomaviruses, polyomaviruses, and herpesviruses in triple-negative and inflammatory breast tumors from algeria compared with other types of breast cancer tumors. PLoS One, 9, 114559. https://doi.org/10.1371/journal.pone.0114559
  8. Dabiri S, Talebi A, Shahryari J, et al (2013). Distribution of myofibroblast cells and microvessels around invasive ductal carcinoma of the breast and comparing with the adjacent range of their normal-to-DCIS zones. Arch Iran Med, 16, 93-9.
  9. Darbre PD, Fernandez MF (2013). Environmental oestrogens and breast cancer: long-term low-dose effects of mixtures of various chemical combinations. J Epidemiol Community Health, 67, 203-5. https://doi.org/10.1136/jech-2012-201362
  10. Deshpande CG, Badve S, Kidwai N, et al (2002). Lack of expression of the epstein-barr virus (EBV) gene products, EBERs, EBNA1, LMP1, and LMP2A, in breast cancer cells. Lab Invest, 82, 1193-9. https://doi.org/10.1097/01.LAB.0000029150.90532.24
  11. Fernandez MF, Santa-Marina L, Ibarluzea JM, et al (2007). Analysis of population characteristics related to the total effective xenoestrogen burden: a biomarker of xenoestrogen exposure in breast cancer. Eur J Cancer, 43, 1290-9. https://doi.org/10.1016/j.ejca.2007.03.010
  12. Ford CE, Faedo M, Crouch R, et al (2004). Progression from normal breast pathology to breast cancer is associated with increasing prevalence of mouse mammary tumor virus-like sequences in men and women. Cancer Res, 64, 4755-9. https://doi.org/10.1158/0008-5472.CAN-03-3804
  13. Forouzanfar MH, Foreman KJ, Delossantos AM, et al (2011). Breast and cervical cancer in 187 countries between 1980 and 2010: a systematic analysis. Lancet, 378, 1461-84. https://doi.org/10.1016/S0140-6736(11)61351-2
  14. Franci C, Zhou J, Jiang Z, et al (2013). Biomarkers of residual disease, disseminated tumor cells, and metastases in the MMTV-PyMT breast cancer model. PLoS One, 8, 58183. https://doi.org/10.1371/journal.pone.0058183
  15. Fukuoka H, Moriuchi M, Yano H, et al (2008). No association of mouse mammary tumor virus-related retrovirus with Japanese cases of breast cancer. J Med Virol, 80, 1447-51. https://doi.org/10.1002/jmv.21247
  16. Goetz F, Tzeng YJ, Guhl E, et al (2001). The SV40 small t-antigen prevents mammary gland differentiation and induces breast cancer formation in transgenic mice; truncated large T-antigen molecules harboring the intact p53 and pRb binding region do not have this effect. Oncogene, 20, 2325-32. https://doi.org/10.1038/sj.onc.1204355
  17. Hippocrate A, Oussaief L, Joab I (2011). Possible role of EBV in breast cancer and other unusually EBV-associated cancers. Cancer Lett, 305, 144-9. https://doi.org/10.1016/j.canlet.2010.11.007
  18. Holland JF, Pogo BG (2004). Mouse mammary tumor virus-like viral infection and human breast cancer. Clin Cancer Res, 10, 5647-9. https://doi.org/10.1158/1078-0432.CCR-04-1234
  19. Ito H, Matsuo K (2015). Molecular epidemiology, and possible real-world applications in breast cancer. Breast Cancer.
  20. Joshi D, Quadri M, Gangane N, et al (2009). Association of Epstein Barr virus infection (EBV) with breast cancer in rural Indian women. PLoS One, 4, 8180. https://doi.org/10.1371/journal.pone.0008180
  21. Mant C, Cason J (2004). A human murine mammary tumour virus-like agent is an unconvincing aetiological agent for human breast cancer. Rev Med Virol, 14, 169-77. https://doi.org/10.1002/rmv.427
  22. Mazouni C, Fina F, Romain S, et al (2011). Epstein-Barr virus as a marker of biological aggressiveness in breast cancer. Br J Cancer, 104, 332-7. https://doi.org/10.1038/sj.bjc.6606048
  23. Mazouni C, Fina F, Romain S, et al (2015). Outcome of Epstein-Barr virus-associated primary breast cancer. Mol Clin Oncol, 3, 295-8.
  24. Mazzanti CM, Al Hamad M, Fanelli G, et al (2011). A mouse mammary tumor virus env-like exogenous sequence is strictly related to progression of human sporadic breast carcinoma. Am J Pathol, 179, 2083-90. https://doi.org/10.1016/j.ajpath.2011.06.046
  25. Melana SM, Picconi MA, Rossi C, et al (2002). [Detection of murine mammary tumor virus (MMTV) env genelike sequences in breast cancer from Argentine patients]. Medicina (B Aires), 62, 323-7.
  26. Motamedifar M, Saki M, Ghaderi A (2012). Lack of association of mouse mammary tumor virus-like sequences in Iranian breast cancer patients. Med Princ Pract, 21, 244-8. https://doi.org/10.1159/000334572
  27. Naderimagham S, Alipour S, Djalalinia S, et al (2014). National and sub-national burden of breast cancer in Iran; 1990-2013. Arch Iran Med, 17, 794-9.
  28. Paredes P, Vidal-Sicart S, Zanon G, et al (2005). Clinical relevance of sentinel lymph nodes in the internal mammary chain in breast cancer patients. Eur J Nucl Med Mol Imaging, 32, 1283-7. https://doi.org/10.1007/s00259-005-1867-z
  29. Rahman M, Ahsan A, Begum F, et al (2015). Epidemiology, Risk Factors and Tumor Profiles of Breast Cancer in Bangladeshi underprivileged women. Gulf J Oncol, 1, 34-42.
  30. Tabriz HM, Zendehdel K, Shahsiah R, et al (2013). Lack of detection of the mouse mammary tumor-like virus (MMTV) Env gene in Iranian women breast cancer using real time PCR. Asian Pac J Cancer Prev, 14, 2945-8. https://doi.org/10.7314/APJCP.2013.14.5.2945
  31. Tao Z, Shi A, Lu C, et al (2014). Breast cancer: epidemiology and etiology. Cell Biochem Biophys.
  32. Veisy A, Lotfinejad S, Salehi K, et al (2015). Risk of breast cancer in relation to reproductive factors in North-West of Iran, 2013-2014. Asian Pac J Cancer Prev, 16, 451-5. https://doi.org/10.7314/APJCP.2015.16.2.451
  33. Vernet-Tomas M, Banos N, Sabadell D, et al (2015). p53 expression in breast cancer predicts tumors with low probability of non-sentinel nodes infiltration. J Obstet Gynaecol Res.
  34. Wang F, Hou J, Shen Q, et al (2014). Mouse mammary tumor virus-like virus infection and the risk of human breast cancer: a meta-analysis. Am J Transl Res, 6, 248-66.
  35. Witt A, Hartmann B, Marton E, et al (2003). The mouse mammary tumor virus-like env gene sequence is not detectable in breast cancer tissue of Austrian patients. Oncol Rep, 10, 1025-9.
  36. Yahia ZA, Adam AA, Elgizouli M, et al (2014). Epstein Barr virus: a prime candidate of breast cancer aetiology in Sudanese patients. Infect Agent Cancer, 9, 9. https://doi.org/10.1186/1750-9378-9-9

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