Asian Pacific Journal of Cancer Prevention

  • 제16권18호
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  • Pages.8053-8058
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Potential Benefit of Metformin as Treatment for Colon Cancer: the Evidence so Far

  • 발행 : 2016.01.11
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초록

Metformin is known as a hypoglycaemic agent that regulates glucose homeostasis by inhibiting liver glucose production and increasing muscle glucose uptake. Colorectal cancer (CRC) is one of the most common cancers worldwide, with about a million new cases diagnosed each year. The risk factors for CRC include advanced age, smoking, black race, obesity, low fibre diet, insulin resistance, and the metabolic syndrome. We have searched Medline for the metabolic syndrome and its relation to CRC, and metformin as a potential treatment of colorectal cancer. Administration of metformin alone or in combination with chemotherapy has been shown to suppress CRC. The mechanism that explains how insulin resistance is associated with CRC is complex and not fully understood. In this review we have summarised studies which showed an association with the metabolic syndrome as well as studies which tackled metformin as a potential treatment of CRC. In addition, we have also provided a summary of how metformin at the cellular level can induce changes that suppress the activity of cancer cells.

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참고문헌

  1. Aleksandrova K, Boeing H, Jenab M, et al (2011). Metabolic syndrome and risks of colon and rectal cancer: the European prospective investigation into cancer and nutrition study. Cancer Prev Res, 4, 1873-83. https://doi.org/10.1158/1940-6207.CAPR-11-0218
  2. Buzzai M, Jones R, Amaravadi R, et al (2007). Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res, 67, 6745-52. https://doi.org/10.1158/0008-5472.CAN-06-4447
  3. Cho Y, Ko B, Kim S, et al (2014). Does metformin affect the incidence of colonic polyps and adenomas in patients with type 2 diabetes mellitus? Intest Res, 12, 139-45. https://doi.org/10.5217/ir.2014.12.2.139
  4. Donohoe C, O'farrell N, Doyle S, Reynolds J (2014). The role of obesity in gastrointestinal cancer: evidence and opinion. Therap Adv Gastroenterol, 7, 38-50. https://doi.org/10.1177/1756283X13501786
  5. Giovannucci E, Pollak M, Platz E, et al (2000). A prospective study of plasma insulin-like growth factor-1 and binding protein-3 and risk of colorectal neoplasia in women. Cancer Epidemiol Biomarkers Prev, 9, 345-9.
  6. Grimberg A & Cohen P (2000). Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol, 183, 1-9. https://doi.org/10.1002/(SICI)1097-4652(200004)183:1<1::AID-JCP1>3.0.CO;2-J
  7. Handelsman Y, Leroith D, Bloomgarden Z, et al (2013). Diabetes and cancer--an AACE/ACE consensus statement. Endocr Pract, 19, 675-93. https://doi.org/10.4158/EP13248.CS
  8. Higurashi T, Takahashi H, Endo H, et al (2012). Metformin efficacy and safety for colorectal polyps: a double-blind randomized controlled trial. BMC Cancer, 12, 118. https://doi.org/10.1186/1471-2407-12-118
  9. Hillon P, Guiu B, Vincent J, Petit J (2010). Obesity, type 2 diabetes and risk of digestive cancer. Gastroenterol Clin Biol, 34, 529-33. https://doi.org/10.1016/j.gcb.2010.07.021
  10. Hsu Y, Chiu H, Liou J, et al (2012). Glycated hemoglobin A1c is superior to fasting plasma glucose as an independent risk factor for colorectal neoplasia. Cancer Causes Control, 23, 321-8. https://doi.org/10.1007/s10552-011-9880-y
  11. Huang HE, Yang YC, Wu JS, et al (2014). The relationship between different glycemic statuses and colon polyps in a Taiwanese population. J Gastroenterol, 49, 1145-51. https://doi.org/10.1007/s00535-013-0863-5
  12. Inoue M, Tsugane S (2012). Insulin resistance and cancer: epidemiological evidence. Endocr Relat Cancer, 19, F1-8. https://doi.org/10.1530/ERC-12-0142
  13. Jenkins P (2004). Acromegaly and cancer. Horm Res, 62, 108-15. https://doi.org/10.1159/000080768
  14. Kalaany N, Sabatini D (2009). Tumours with PI3K activation are resistant to dietary restriction. Nature, 458, 725-31. https://doi.org/10.1038/nature07782
  15. Kanadiya M, Gohel T, Sanaka M, Thota P, Shubrook J (2013). Relationship between type-2 diabetes and use of metformin with risk of colorectal adenoma in an American population receiving colonoscopy. J Diabetes Complications, 27, 463-6. https://doi.org/10.1016/j.jdiacomp.2013.04.010
  16. Kaneko R, Nakazaki N, Tagawa T, et al (2014) A new index of abdominal obesity which effectively predicts risk of colon tumor development in female Japanese. Asian Pac J Cancer Prev, 15, 1005-10. https://doi.org/10.7314/APJCP.2014.15.2.1005
  17. Khaw K, Wareham N, Bingham S, et al (2004). Preliminary communication: glycated hemoglobin, diabetes, and incident colorectal cancer in men and women: a prospective analysis from the European prospective investigation into cancer-Norfolk study. Cancer Epidemiol Biomarkers Prev, 13, 915-9.
  18. Kim D (2012). [Obesity and gastrointestinal cancer-related factor]. Korean J Gastroenterol, 59, 8-15. https://doi.org/10.4166/kjg.2012.59.1.8
  19. Larsson S, Wolk A (2007). Obesity and colon and rectal cancer risk: a meta-analysis of prospective studies. Am J Clin Nutr, 86, 556-65. https://doi.org/10.1093/ajcn/86.3.556
  20. Lee D, Kim B, Lee J, et al (2012). The effect of metformin on responses to chemotherapy and survival in stage IV colorectal cancer with diabetes. Korean J Gastroenterol, 60, 355-61. https://doi.org/10.4166/kjg.2012.60.6.355
  21. Lega I, Shah P, Margel D, et al (2014). The effect of metformin on mortality following cancer among patients with diabetes. Cancer Epidemiol Biomarkers Prev, 23, 1974-84. https://doi.org/10.1158/1055-9965.EPI-14-0327
  22. Li W, Wang Q, Liu X, et al (2015). Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice. Cancer Prev Res, 8, 139-48. https://doi.org/10.1158/1940-6207.CAPR-14-0128
  23. Mahmood K, Naeem M & Rahimnajjad N (2013). Metformin: the hidden chronicles of a magic drug. Eur J Intern Med, 24, 20-6. https://doi.org/10.1016/j.ejim.2012.10.011
  24. Mei Z, Zhang Z, Liu C, et al (2014). Survival benefits of metformin for colorectal cancer patients with diabetes: a systematic review and meta-analysis. PLoS One, 9, 91818. https://doi.org/10.1371/journal.pone.0091818
  25. Mulholland H, Murray L, Cardwell C & Cantwell M (2009). Glycemic index, glycemic load, and risk of digestive tract neoplasms: a systematic review and meta-analysis. Am J Clin Nutr, 89, 568-76. https://doi.org/10.3945/ajcn.2008.26823
  26. Na S & Myung S (2012). [Obesity and colorectal cancer]. Korean J Gastroenterol, 59, 16-26. https://doi.org/10.4166/kjg.2012.59.1.16
  27. Ogden C, Carroll M, Curtin L, et al (2006). Prevalence of overweight and obesity in the United States, 1999-2004. JAMA, 295, 1549-55. https://doi.org/10.1001/jama.295.13.1549
  28. Pais R, Silaghi H, Silaghi A, Rusu M & Dumitrascu D (2009). Metabolic syndrome and risk of subsequent colorectal cancer. World J Gastroenterol, 15, 5141-8. https://doi.org/10.3748/wjg.15.5141
  29. Rampal S, Yang MH, Sung J, et al (2014). Association between markers of glucose metabolism and risk of colorectal adenoma. Gastroenterol, 147, 78-87. https://doi.org/10.1053/j.gastro.2014.03.006
  30. Renehan A, Roberts D, Dive C (2008). Obesity and cancer: pathophysiological and biological mechanisms. Arch Physiol Biochem, 114, 71-83. https://doi.org/10.1080/13813450801954303
  31. Sanchez N, Stierman B, Saab S, et al (2012). Physical activity reduces risk for colon polyps in a multiethnic colorectal cancer screening population. BMC Res Notes, 5, 312. https://doi.org/10.1186/1756-0500-5-312
  32. Sandhu M, Dunger D, Giovannucci E (2002). Insulin, insulinlike growth factor-I (IGF-I), IGF binding proteins, their biologic interactions, and colorectal cancer. J Natl Cancer Inst, 94, 972-80. https://doi.org/10.1093/jnci/94.13.972
  33. Saydah SH, Platz EA, Rifai N, et al (2003). Association of markers of insulin and glucose control with subsequent colorectal cancer risk. Cancer Epidemiol Biomarkers Prev, 12, 412-8.
  34. Schoenalgire C, Amrein L, Zakikhani M, Panasci L & Pollak M (2010). Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocr Relat Cancer, 17, 351-60. https://doi.org/10.1677/ERC-09-0252
  35. Spillane S, Bennett K, Sharp L, Barron T (2014). Metformin exposure and disseminated disease in patients with colorectal cancer. Cancer Epidemiol, 38, 79-84. https://doi.org/10.1016/j.canep.2013.12.003
  36. Sui X, Xu Y, Yang J, et al (2014). Use of metformin alone is not associated with survival outcomes of colorectal cancer cell but AMPK activator AICAR sensitizes anticancer effect of 5-fluorouracil through AMPK activation. PLoS One, 9, 97781. https://doi.org/10.1371/journal.pone.0097781
  37. Trevisan M, Liu J, Muti P, et al (2001). Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev, 10, 937-41.
  38. Tsilidis K, Capothanassi D, Allen N, et al (2014). Metformin does not affect cancer risk: a cohort study in the U.K. Clinical Practice Research Datalink analyzed like an intention-totreat trial. Diabetes Care, 37, 2522-32. https://doi.org/10.2337/dc14-0584
  39. Vu HT, Ufere N, Yan Y, et al (2014). Diabetes mellitus increases risk for colorectal adenomas in younger patients. World J Gastroenterol, 20, 6946-52. https://doi.org/10.3748/wjg.v20.i22.6946
  40. Wang X, Zhang Y (2014). Targeting mTOR network in colorectal cancer therapy. World J Gastroenterol, 20, 4178-88. https://doi.org/10.3748/wjg.v20.i15.4178
  41. Warren R, Yuan H, Matli M, Ferrara N, Donner D (1996). Induction of vascular endothelial growth factor by insulinlike growth factor 1 in colorectal carcinoma. J Biol Chem, 271, 29483-8. https://doi.org/10.1074/jbc.271.46.29483
  42. Williams A, Collard T, Perks C, et al (2000). Increased p53- dependent apoptosis by the insulin-like growth factor binding protein IGFBP-3 in human colonic adenoma-derived cells. Cancer Res, 60, 22-7.
  43. Yun K, Chang Y, Jung H, et al (2013). Impact of body mass index on the risk of colorectal adenoma in a metabolically healthy population. Cancer Res, 73, 4020-7. https://doi.org/10.1158/0008-5472.CAN-12-3477
  44. Zaafar D, Zaitone S & Moustafa Y (2014). Role of metformin in suppressing 1,2-dimethylhydrazine-induced colon cancer in diabetic and non-diabetic mice: effect on tumor angiogenesis and cell proliferation. PLoS One, 9, 100562. https://doi.org/10.1371/journal.pone.0100562
  45. Zaninotto P, Pierce M, Breeze E, De Oliveira C, Kumari M (2010). BMI and waist circumference as predictors of wellbeing in older adults: findings from the english longitudinal study of ageing. Obesity, 18, 1981-7. https://doi.org/10.1038/oby.2009.497
  46. Zhang P, Li H, Tan X, Chen L, Wang S (2013a). Association of metformin use with cancer incidence and mortality: a metaanalysis. Cancer Epidemiol, 37, 207-18. https://doi.org/10.1016/j.canep.2012.12.009
  47. Zhang Y, Guan M, Zheng Z, et al (2013b). Effects of metformin on CD133+ colorectal cancer cells in diabetic patients. PLoS

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