Asian Pacific Journal of Cancer Prevention

  • 제16권18호
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  • Pages.8625-8628
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Could Tumor Size Be A Predictor for Papillary Thyroid Microcarcinoma: a Retrospective Cohort Study

  • Wang, Min (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Wu, Wei-Dong (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Chen, Gui-Ming (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Chou, Sheng-Long (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Dai, Xue-Ming (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Xu, Jun-Ming (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University) ;
  • Peng, Zhi-Hai (Department of General Surgery, Shanghai General Hospital of Nanjing Medical University, Nanjing Medical University)
  • 발행 : 2016.01.11
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초록

Background: Central lymph node metastasis(CLNM) is common in papillary thyroid microcarcinoma (PTMC). The aim of this study was to define the pathohistologic risk grading based on surgical outcomes. Materials and Methods: Statistical analysis was performed to figure out the optimal cut-off values of size in preoperative ultrasound images for defining the risk of CLNM in papillary thyroid microcarcinoma. Receiver operating characteristic curves (ROC) studies were carried out to determine the cutoff value(s) for the predictor(s). All the patients were divided into two groups according to the above size and the clinic-pathological and immunohistochemical parameters were compared to determine the significance of findings. Results: The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. Significant differences were observed on the multifocality, extrathyroidal extension and central lymph node metastasis between two groups which were divided according to the tumor size by the cutoff values. Patients in two groups showed different positive rate and intensity of Ki67. Conclusions: The size of PTMC in ultrasound images are helpful to predict the aggressiveness of the tumors, it could be an easy predictor for PTMC prognosis and assist us to choose treatment.

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참고문헌

  1. Appetecchia M, Scarcello G, Pucci E, et al (2002). Outcome after treatment of papillary thyroid microcarcinoma. J Exp Clin Cancer Res, 21, 159-64.
  2. Byar DP, Green SB, Dor P, Williams ED, et al (1979). A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative Group. Eur J Cancer, 15, 1033-41. https://doi.org/10.1016/0014-2964(79)90291-3
  3. Chang YW, Kim HS, Kim HY, et al (2015).Should central lymph node dissection be considered for all papillary thyroid microcarcinoma. Asian J Surg, 22, 1-5.
  4. Chow SM, Law SCK, Chan JKC, et al (2003). Papillary microcarcinoma of the thyroiddprognostic significance of lymph node metastasis and multifocality. Cancer, 98, 31-40. https://doi.org/10.1002/cncr.11442
  5. Edge SB, Compton CC(2010). The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol, 17, 1471-4. https://doi.org/10.1245/s10434-010-0985-4
  6. Guay B1, Johnson-Obaseki S, McDonald JT, et al (2014). Incidence of differentiated thyroid cancer by socioeconomic status and urban residence: Canada 1991-2006. Thyroid, 24, 552-5. https://doi.org/10.1089/thy.2013.0308
  7. Ito Y, Nikiforov YE, Schlumberger M, et al (2013). Increasing incidence of thyroid cancer: controversies explored. Nat Rev Endocrinol, 9, 178-84. https://doi.org/10.1038/nrendo.2012.257
  8. Jeon SJ, Kim E, Park JS, et al (2009). Diagnostic benefit of thyroglobulin measurement in fine-needle aspiration for diagnosing metastatic cervical lymph nodes from papillary thyroid cancer correlations with US features. Korean J Radiol, 10, 106-11. https://doi.org/10.3348/kjr.2009.10.2.106
  9. Levin KE, Clark AH, Duh QY, et al (1992). Reoperative thyroid surgery. Surg, 111, 604-9.
  10. Lim YC, Choi EC, Yoon YH, et al (2009). Central lymph node metastases in unilateral papillary thyroid microcarcinoma. Br J Surg, 96, 253-7. https://doi.org/10.1002/bjs.6484
  11. Roh JL, Kim JM, Park CI (2008). Central cervical nodal metastasis from papillary thyroid microcarcinoma: pattern and factors predictive of nodal metastasis. Ann Surg Oncol, 15, 2482-6. https://doi.org/10.1245/s10434-008-0044-6
  12. Udelsman R, Lakatos E, Ladenson P (1996). Optimal surgery for papillary thyroid carcinoma. World J Surg, 20, 88-93. https://doi.org/10.1007/s002689900016
  13. Vanden Bruel A, Francart J, Dubois C, et al (2013). Regional variation in thyroid & cancer incidence in Belgium is associated with variation in thyroid imaging and thyroid disease management. J Clin Endocrinol Metab, 98, 4063-71. https://doi.org/10.1210/jc.2013-1705
  14. Vigneri R, Malandrino P, Vigneri P (2015). The changing epidemiology of thyroid cancer: why is incidence increasing. Curr Opin Oncol, 27, 1-7. https://doi.org/10.1097/CCO.0000000000000148
  15. Vini L, Hyer SL, Marshall J, et al (2003). Long-term results in elderly patients with differentiated thyroid carcinoma. Cancer, 97, 2736-42. https://doi.org/10.1002/cncr.11410
  16. Riemann B, Schober O (2009). Therapeutic strategy of papillary microcarcinoma of the thyroid gland: a nuclear medicine perspective. Minerva Endocrinol, 34, 81-7.
  17. Wada N, Duh QY, Sugino K, et al (2003). Lymph node metastasis from 259 papillary thyroid microcarcinomas: frequency, pattern of occurrence and recurrence, and optimal strategy for neck dissection. Ann Surg, 237, 399-407.
  18. Wang TS, Goffredo P, Sosa JA, et al (2014). Papillary thyroid microcarcinoma: an over-treated malignancy. World J Surg, 38, 2297-303. https://doi.org/10.1007/s00268-014-2602-3
  19. Zafon C, Baena JA, Castellvi J, et al (2010). Differences in the form of presentation between papillary microcarcinoma and papillary carcinomas of larger size. J Thyroid Res, 14, 1-5.
  20. Zhang L, Wei WJ, Ji QH, et al (2012). Risk factors for neck nodal metastasis in papillary thyroid microcarcinoma: a study of 1066 patients. J Clin Endocrinol Metab, 97, 1250-57. https://doi.org/10.1210/jc.2011-1546
  21. Zhou Y, Jiang HG, Lu N, et al (2015). Expression of Ki67 in papillary thyroid microcarcinoma and its clinical significance. Asian Pac J Cancer Prev, 16, 1605-8. https://doi.org/10.7314/APJCP.2015.16.4.1605

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  1. Values of ultrasound features and MMP-9 of papillary thyroid carcinoma in predicting cervical lymph node metastases vol.7, pp.1, 2017, https://doi.org/10.1038/s41598-017-07118-7