Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
권호 표지
DOI QR코드

DOI QR Code

Helicobacter Pylori Associated Gastritis Increases Risk of Colorectal Polyps: a Hospital Based-Cross-Sectional Study in Nakhon Ratchasima Province, Northeastern Thailand

  • Tongtawee, Taweesak (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Kaewpitoon, Soraya (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Kaewpitoon, Natthawut (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Dechsukhum, Chavaboon (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Leeanansaksiri, Wilairat (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Loyd, Ryan A (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Matrakool, Likit (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology) ;
  • Panpimanmas, Sukij (Suranaree University of Technology Hospital, Institute of Medicine, Suranaree University of Technology)
  • Published : 2016.02.05
Download PDF
⟨ Previous Next ⟩

Abstract

Background: Colorectal polyps are common in Thailand, particularly in the northeastern region. The present study aimed to determine any correlation between Helicobacter pylori-associated gastritis and colorectal polyps in the Thai population. Materials and Methods: A total of 303 patients undergoing esophagogastroduodenoscopy with colonoscopy for investigation of chronic abdominal pain participated in this study from November 2014 to October 2015. A diagnosis of Helicobacter pylori associated gastritis was made if the bacteria were seen on histopathological examination and a rapid urease test was positive. Colorectal polyps were confirmed by histological examination of colorectal biopsies. Patient demographic data were analyzed for correlations. Results: The prevalence of colorectal polyps was 77 (25.4%), lesions being found more frequently in Helicobacter pylori infected patients than non-infected subjects [38.4% vs. 12.5%; Odds Ratio (OR) (95% CI): 2.26 (1.32 - 3.86), p < 0.01]. Patients with Helicobacter pylori - associated gastritis were at high risk of having adenomas featuring dysplasia [OR (95% CI): 1.15 (1.16 - 7.99); P = 0.02]. There was no varaition in location of polyps, age group, sex and gastric lesions with respect to Helicobacter pylori status. Conclusions: This study showed that Helicobacter pylori associated gastritis is associated with an increased risk of colorectal polyps, especially adenomas with dysplasia in the Thai population. Patients with Helicobacter pylori-associated gastritis may benefit from concurrent colonoscopy for diagnosis of colorectal polyps as a preventive and early treatment for colorectal cancer.

Keywords

References

  1. Aarbakke J, Schjonsby H (1976). Value of urinary simple phenol and indican determinations in the diagnosis of the stagnant loop syndrome. Scand J Gastroenterol, 11, 409-14.
  2. Brew R, Erikson JS, West DC, et al (2000). Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro. Cytokine, 12, 78-85. https://doi.org/10.1006/cyto.1999.0518
  3. Ciccotosto GD, McLeish A, Hardy KJ, et al (1995). Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterol, 109, 1142- 53. https://doi.org/10.1016/0016-5085(95)90572-3
  4. De Stefani E, Ronco AL, Boffetta P, et al (2012). Nutrient derived dietary patterns and risk of colorectal cancer: a factor analysis in Uruguay. Asian Pac J Cancer Prev, 13, 231-5. https://doi.org/10.7314/APJCP.2012.13.1.231
  5. Drasar BS, Shiner M, McLeod M, et al (1969). Studies on the intestinal flora. I. The bacterial flora of the gastrointestinal tract in healthy and achlorhydric persons. Gastroenterol, 56, 71-9.
  6. Durko L, Malecka-Panas E (2014). Lifestyle Modifications and Colorectal Cancer. Curr Colorectal Cancer Rep, 10, 45-54. https://doi.org/10.1007/s11888-013-0203-4
  7. Fireman Z, Trost L, Kopelman Y, et al (2000). Helicobacter pylori: seroprevalence and colorectal cancer. Isr Med Assoc J, 2, 6-9.
  8. Ganesh B, Talole SD, Dikshit R (2009). A case-control study on diet and colorectal cancer from Mumbai, India. Cancer Epidemiol, 33, 189-93. https://doi.org/10.1016/j.canep.2009.07.009
  9. Georgopoulos SD, Polymeros D, Triantafyllou K, et al (2006). Hypergastrinemia is associated with increased risk of distal colon adenomas. Digest, 74, 42-6. https://doi.org/10.1159/000096593
  10. Horie H, Kanazawa K, Okada M, et al (1999). Effects of intestinal bacteria on the development of colonic neoplasm: an experimental study. Eur J Cancer Prev, 8, 237-45. https://doi.org/10.1097/00008469-199906000-00012
  11. Hong SN, Lee SM, Kim JH, et al (2012). Helicobacter pylori infection increases the risk of colorectal adenomas: crosssectional study and meta-analysis. Dig Dis Sci, 57, 2184-94. https://doi.org/10.1007/s10620-012-2245-x
  12. Howden CW and Hunt RH (1987). Relationship between gastric secretion and infection. Gut, 28, 96-107. https://doi.org/10.1136/gut.28.1.96
  13. Hsing AW, McLaughlin JK, Chow WH, et al (1998). Risk factors for colorectal cancer in a prospective study among U.S. white men. Int J Cancer, 77, 549-53. https://doi.org/10.1002/(SICI)1097-0215(19980812)77:4<549::AID-IJC13>3.0.CO;2-1
  14. Jones M, Helliwell P, Pritchard C, et al (2007).Helicobacter pylori in colorectal neoplasms: is there an a etiological relationship? World J Surg Oncol, 5, 51. https://doi.org/10.1186/1477-7819-5-51
  15. Kado S, Uchida K, Funabashi H, et al (2001). Intestinal microfloras are necessary for development of spontaneousadenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Cancer Res, 61, 2395- 8.
  16. Kirati Poomphakwaen, Supannee Promthet, Krittika Suwanrungruang, et al (2015). Risk Factors for Colorectal Cancer in Thailand. Asian Pac J Cancer Prev, 16, 6105-09. https://doi.org/10.7314/APJCP.2015.16.14.6105
  17. Lin YL, Chiang JK, Lin SM, et al (2010). Helicobacter pylori infection concomitant with metabolic syndrome further increase risk of colorectal adenomas. World J Gastroenterol, 16, 3841- 6. https://doi.org/10.3748/wjg.v16.i30.3841
  18. Moore WE, Moore LH (1995). Intestinal floras of populations that have a high risk of colon cancer. Appl Environ Microbiol, 61, 3202-7.
  19. National Cancer Institute (2012). Cancer in Bangkok Thailand. 6, 2004-2006, .
  20. Penman ID, el-Omar E, Ardill JE, et al (1994). Plasma gastrin concentrations are normal in patients with colorectal neoplasia and unaltered following tumor resection. Gastroenterol, 106, 1263-70. https://doi.org/10.1016/0016-5085(94)90018-3
  21. Pitulak Aswakul, Varayu Prachayakul1, Varut Lohsiriwat, et al (2012). Screening colonoscopy from a large single center of Thailand: Something needs to be changed? Asian Pac J Cancer Prev, 13, 1361-4. https://doi.org/10.7314/APJCP.2012.13.4.1361
  22. Shmuely H, Passaro D, Figer A, et al (2001). Relationship between Helicobacter pylori CagA status and colorectal cancer. Am J Gastroenterol, 96, 3406-10. https://doi.org/10.1111/j.1572-0241.2001.05342.x
  23. Taweesak T, Soraya K, Natthawut K, et al (2015). Correlation between Gastric Mucosal Morphologic Patterns and Histopathological Severity of Helicobacter pylori Associated Gastritis Using Conventional Narrow Band Imaging Gastroscopy. Biomed Res Int, 7, 42-8.
  24. Thorens J, Froehlich F, Schwizer W, et al (1996). Bacterial overgrowth during treatment with omeprazole compared with cimetidine: a prospective randomized double blind study. Gut, 39, 54-9. https://doi.org/10.1136/gut.39.1.54
  25. Thorburn CM, Friedman GD, et al (1998). Gastrin and colorectal cancer: a prospective study. Gastroenterol, 115, 275-80. https://doi.org/10.1016/S0016-5085(98)70193-3
  26. Uchida T, Miftahussurur M, Pittayanon R, et al (2015). Helicobacter pylori Infection in Thailand: A Nationwide Study of the CagA Phenotype. PLoS ONE, 10, 9.
  27. Visek WJ (1978). Diet and cell growth modulation by ammonia. Am J Clin Nutr, 31, 216-20. https://doi.org/10.1093/ajcn/31.10.S216
  28. Wang F, Sun MY, Shi SL, et al (2014). Helicobacter pylori infection and normal colorectal mucosa-adenomatous polyp-adenocarcinoma sequence: a meta-analysis of 27 case-control studies. Colorectal Dis, 16, 246-52. https://doi.org/10.1111/codi.12290
  29. Wang J, Zhao Y, Jiang J, et al (2010). Polymorphisms in DNA repair genes XRCC1, XRCC3 and XPD, and colorectal cancer risk: A case-control study in an Indian population. J Cancer Res Clin Oncol, 136, 1517-25. https://doi.org/10.1007/s00432-010-0809-8
  30. William R, Brown, Dennis J, et al (2015). The international health care burden of cancers of the gastrointestinal tract and liver. Cancer Research Frontiers, 1, 1-9.
  31. Zhao YS, Wang F, Chang D, et al (2008). Meta-analysis of different test indicators: Helicobacter pylori infection and the risk of colorectal cancer. Int J Colorectal Dis, 23, 875-882. https://doi.org/10.1007/s00384-008-0479-z
  32. Zumkeller N, Brenner H, Zwahlen M, et al (2006). Helicobacter pylori infection and colorectal cancer risk:a meta-analysis. Helicobacter, 11, 75-80. https://doi.org/10.1111/j.1523-5378.2006.00381.x
  33. Zumkeller N, Brenner H, Zwahlen M, et al (2006).Helicobacter pylori infection and colorectal cancer risk: a meta-analysis. Helicobacter, 11, 75-80. https://doi.org/10.1111/j.1523-5378.2006.00381.x

Cited by

  1. Toll-Like Receptors are Associated with Helicobacter pylori Infection and Gastric Mucosa Pathology vol.In Press, pp.In Press, 2017, https://doi.org/10.5812/jjm.58351