Asian Pacific Journal of Cancer Prevention

  • 제17권3호
  • /
  • Pages.1009-1014
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Effects of TNFalpha, NOS3, MDR1 Gene Polymorphisms on Clinical Parameters, Prognosis and Survival of Multiple Myeloma Cases

  • Basmaci, C (Department of Hematology, Gaziantep University Faculty of Medicine) ;
  • Pehlivan, M (Department of Hematology, Gaziantep University Faculty of Medicine) ;
  • Tomatir, AG (Department of Medical Biology, Pamukkale University, Faculty of Medicine) ;
  • Sever, T (Department of Medical Biology and Genetics, Gaziantep University Faculty of Medicine) ;
  • Okan, V (Department of Hematology, Gaziantep University Faculty of Medicine) ;
  • Yilmaz, M (Department of Hematology, Gaziantep University Faculty of Medicine) ;
  • Oguzkan-Balci, S (Department of Medical Biology and Genetics, Gaziantep University Faculty of Medicine) ;
  • Pehlivan, S (Department of Medical Biology, Istanbul University, Istanbul Medical Faculty)
  • 발행 : 2016.04.11
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초록

It is not clear how gene polymorphisms affecting drugs can contributes totheir efficacy in multiple myeloma (MM). We here aimed to explore associations among gene polymorphisms of tumor necrosis factor alpha (TNFalpha), nitric oxide synthesis 3 (NOS3) and multi-drug resistance 1 (MDR1), clinical parameters, prognosis and survival in MM patients treated with VAD (vincristine-adriamycine-dexamethasone), MP (mephalane-prednisolone), autolougus stem cell transplantation (ASCT), BODEC (bortezomib-dexamethasone-cyclophosphamide) and TD (thalidomide-dexamethasone). We analyzed TNFalpha, NOS 3 and MDR1 in 77 patients with MM and 77 healthy controls. The genotyping was performed with PCR and/or PCR-RFLP. There was no clinically significant difference between MM and control groups when TNFalpha (-238) and (-857) and MDR1 gene polymorphisms were studied. However, the TNFalpha gene polymorphism (-308) GG genotype (p=0.012) and NOS3 (+894) TT genotype (p=0.008) were more common in the MM group compared to healthy controls. NOS3 (VNTR) AA (p=0.007) and NOS3 (+894) GG genotypes (p=0.004) were decreased in the MM group in contrast. In conclusion, the NOS3 (+894) TT and TNFalpha (-308) GG genotypes may have roles in myeloma pathogenesis.

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참고문헌

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