Nutrition Research and Practice

The Korean Nutrition Society (한국영양학회)
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Fermentation of purple Jerusalem artichoke extract to improve the α-glucosidase inhibitory effect in vitro and ameliorate blood glucose in db/db mice

  • Wang, Zhiqiang (Department of Food Science and Nutrition, Hallym University) ;
  • Hwang, Seung Hwan (Department of Food Science and Nutrition, Hallym University) ;
  • Lee, Sun Youb (Natural Resources Commercialization, Chuncheon Bioindustry Foundation) ;
  • Lim, Soon Sung (Department of Food Science and Nutrition, Hallym University)
  • Received : 2015.10.13
  • Accepted : 2015.12.15
  • Published : 2016.06.01
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Abstract

BACKGROUND/OBJECTIVES: Jerusalem artichoke has inhibitory activity against ${\alpha}$-glucosidase and decreases fasting serum glucose levels, which may be related to its fructan content. The biological activity of fructan can be influenced by the degree of polymerization. Thus, in this study, the inhibitory effects of original and fermented purple Jerusalem artichoke (PJA) on ${\alpha}$-glucosidase were compared in vitro. Additionally, the anti-diabetes effect of Lactobacillus plantarum-fermented PJA (LJA) was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db). MATERIALS/METHODS: The water extract of PJA was fermented by L. plantarum, and two strains of Bacillus subtilis to compare their anti-${\alpha}$-glucosidase activities in vitro by ${\alpha}$-glucosidase assays. The anti-diabetes effect of LJA was studied in a non-insulin-dependent diabetes mellitus animal model (C57BIKsJ db/db) for seven weeks. During the experiment, food intake, body weight, and fasting blood glucose were measured every week. At the end of the treatment period, several diabetic parameters and the intestinal ${\alpha}$-glucosidase activity were measured. RESULTS: The LJA showed the highest ${\alpha}$-glucosidase inhibitory activity in vitro. In the in vivo study, it resulted in a significantly lower blood glucose concentration than the control. Serum insulin and HDL cholesterol levels were significantly higher and the concentrations of triglycerides, non-esterified fatty acids, and total cholesterol were significant lower in mice treated with LJA after seven weeks. In addition, the intestinal ${\alpha}$-glucosidase activity was partially inhibited. CONCLUSIONS: These results suggested that LJA regulates blood glucose and has potential use as a dietary supplement.

Keywords

References

  1. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus--present and future perspectives. Nat Rev Endocrinol 2012;8:228-36. https://doi.org/10.1038/nrendo.2011.183
  2. Fuller JH, Shipley MJ, Rose G, Jarrett RJ, Keen H. Coronary-heart-disease risk and impaired glucose tolerance. The Whitehall study. Lancet 1980;1:1373-6.
  3. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2010;33 Suppl 1:S62-9. https://doi.org/10.2337/dc10-S062
  4. Krasikov VV, Karelov DV, Firsov LM. $\alpha$-Glucosidases. Biochemistry (Mosc) 2001;66:267-81. https://doi.org/10.1023/A:1010243611814
  5. Scheen AJ. Is there a role for $\alpha$-glucosidase inhibitors in the prevention of type 2 diabetes mellitus? Drugs 2003;63:933-51. https://doi.org/10.2165/00003495-200363100-00002
  6. Holman RR, Turner RC. Oral agents and insulin in the treatment of NIDDM. In: Pickup JC, Williams G, editors. Textbook of Diabetes. Oxford: Blackwell; 1991. p. 467-9.
  7. Kim SH, Hyun SH, Choung SY. Anti-diabetic effect of cinnamon extract on blood glucose in db/db mice. J Ethnopharmacol 2006;104:119-23. https://doi.org/10.1016/j.jep.2005.08.059
  8. Rojo LE, Ribnicky D, Logendra S, Poulev A, Rojas-Silva P, Kuhn P, Dorn R, Grace MH, Lila MA, Raskin I. In vitro and in vivo anti-diabetic effects of anthocyanins from Maqui Berry (Aristotelia chilensis). Food Chem 2012;131:387-96. https://doi.org/10.1016/j.foodchem.2011.08.066
  9. Chernenko TV, Glushenkova AI, Rakhimov DA. Lipids of Helianthus tuberosus tubers. Chem Nat Compd 2008;44:1-2. https://doi.org/10.1007/s10600-008-0001-4
  10. Kim HS, Han GD. Hypoglycemic and hepatoprotective effects of Jerusalem artichoke extracts on streptozotocin-induced diabetic rats. Food Sci Biotechnol 2013;22:1121-4. https://doi.org/10.1007/s10068-013-0192-8
  11. Rumessen JJ, Bode S, Hamberg O, Gudmand-Hoyer E. Fructans of Jerusalem artichokes: intestinal transport, absorption, fermentation, and influence on blood glucose, insulin, and C-peptide responses in healthy subjects. Am J Clin Nutr 1990;52:675-81. https://doi.org/10.1093/ajcn/52.4.675
  12. Park BS. Effect of oral administration of Jerusalem artichoke inulin on reducing blood lipid and glucose in STZ-induced diabetic rats. J Anim Vet Adv 2011;10:2501-7. https://doi.org/10.3923/javaa.2011.2501.2507
  13. Kaur N, Gupta AK. Applications of inulin and oligofructose in health and nutrition. J Biosci 2002;27:703-14. https://doi.org/10.1007/BF02708379
  14. Mohamed Sham Shihabudeen H, Hansi Priscilla D, Thirumurugan K. Cinnamon extract inhibits $\alpha$-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab (Lond) 2011;8:46. https://doi.org/10.1186/1743-7075-8-46
  15. Barham D, Trinder P. An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst (Lond) 1972;97:142-5. https://doi.org/10.1039/an9729700142
  16. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem 1951;193:265-75.
  17. Jung HW, Jung JK, Ramalingam M, Yoon CH, Bae HS, Park YK. Anti-diabetic effect of Wen-pi-tang-Hab-Wu-ling-san extract in streptozotocin-induced diabetic rats. Indian J Pharmacol 2012;44:97-102. https://doi.org/10.4103/0253-7613.91877
  18. Baldini M, Danuso F, Turi M, Vannozzi GP. Evaluation of new clones of Jerusalem artichoke (Helianthus tuberosus L.) for inulin and sugar yield from stalks and tubers. Ind Crops Prod 2004;19:25-40. https://doi.org/10.1016/S0926-6690(03)00078-5
  19. Rakhimov DA, Arifkhodzhaev AO, Mezhlumyan LG, Yuldashev OM, Rozikova UA, Aikhodzhaeva N, Vakil MM. Carbohydrates and proteins from Helianthus tuberosus. Chem Nat Compd 2003;39:312-3. https://doi.org/10.1023/A:1025443107255
  20. Suseelan KN, Mitra R, Pandey R, Sainis KB, Krishna TG. Purification and characterization of a lectin from wild sunflower (Helianthus tuberosus L.) tubers. Arch Biochem Biophys 2002;407:241-7. https://doi.org/10.1016/S0003-9861(02)00517-9
  21. Boillot J, Alamowitch C, Berger AM, Luo J, Bruzzo F, Bornet FR, Slama G. Effects of dietary propionate on hepatic glucose production, whole-body glucose utilization, carbohydrate and lipid metabolism in normal rats. Br J Nutr 1995;73:241-51. https://doi.org/10.1079/BJN19950026
  22. Luo J, Rizkalla SW, Alamowitch C, Boussairi A, Blayo A, Barry JL, Laffitte A, Guyon F, Bornet FR, Slama G. Chronic consumption of short-chain fructooligosaccharides by healthy subjects decreased basal hepatic glucose production but had no effect on insulinstimulated glucose metabolism. Am J Clin Nutr 1996;63:939-45. https://doi.org/10.1093/ajcn/63.6.939
  23. Yang HJ, Kwon DY, Kim MJ, Kang S, Kim DS, Park S. Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats. Nutr Metab (Lond) 2012;9:112. https://doi.org/10.1186/1743-7075-9-112
  24. Delzenne NM, Kok N. Effect of non-digestible fermentable carbohydrates on hepatic fatty acid metabolism. Biochem Soc Trans 1998;26:228-30. https://doi.org/10.1042/bst0260228

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