Asian Pacific Journal of Cancer Prevention

  • 제17권7호
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  • Pages.3601-3604
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  • 2016
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  • 1513-7368(pISSN)
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  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
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Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients

  • Mardani, Maryam (Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Andisheh-Tadbir, Azadeh (Prevention of Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences) ;
  • Khademi, Bijan (Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences) ;
  • Melekzadeh, Mahyar (Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences) ;
  • Vaziri, Lida (Undergraduate Student, School of Dentistry Shiraz University of Medical Sciences)
  • 발행 : 2016.07.01
⟨ 이전 논문 다음 논문 ⟩

초록

Background: The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemoattractant for natural killer cells, monocytes, and memory T lymphocytes. However, any role in the genesis of salivary gland tumors (SGT) is unknown. To assess the diagnostic relevance of chemokines in SGT, MCP-1 levels in the serum of patients were investigated in association with tumor progression and clinical aggressiveness. Materials and Methods: Using an ELISA kit, we assessed and compared the circulating levels of MCP-1 in blood serum of 70 SGT patients with 44 healthy control samples. Results: The results of this study showed that the concentration of MCP-1 was significantly lower in patients with benign ($463.8{\pm}158.5pg/ml$, P=0.033) and malignant ($454.8{\pm}190.4pg/ml$, P=0.007) SGT than in healthy subjects ($645.7{\pm}338.9$). No significant difference in mean serum levels of MCP-1 was observed between the benign and malignant group (p=0.9). While MCP-1 levels were lower in patients with an advanced clinical stage, advanced tumor size, higher tumor grade, or lymph node involvement, but the mean MCP-1 level between groups showed no statistically significant difference (p>0.05). Conclusions: MCP-1 levels in the serum of patients with SGT were decreased, indicating that this might a good marker for discriminating patients with SGT from healthy people. However, no clear-cut relationship was detected between MCP-1 levels and clinicopathologic factors, and MCP-1 is not a good marker for evaluating tumor dissemination.

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과제정보

연구 과제 주관 기관 : Shiraz University of Medical Sciences

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