The Korean Journal of Physiology and Pharmacology

  • 제20권4호
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  • Pages.407-414
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  • 2016
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Involvement of spinal muscarinic and serotonergic receptors in the anti-allodynic effect of electroacupuncture in rats with oxaliplatin-induced neuropathic pain

  • Lee, Ji Hwan (Department of Science in Korean Medicine, Graduate School, Kyung Hee University) ;
  • Go, Donghyun (Department of East-West Medicine, Graduate School, Kyung Hee University) ;
  • Kim, Woojin (Department of East-West Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Giseog (Department of East-West Medicine, Graduate School, Kyung Hee University) ;
  • Bae, Hyojeong (Department of East-West Medicine, Graduate School, Kyung Hee University) ;
  • Quan, Fu Shi (Department of Medical Zoology, School of Medicine, Kyung Hee University) ;
  • Kim, Sun Kwang (Department of Science in Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2016.03.03
  • 심사 : 2016.06.01
  • 발행 : 2016.07.01
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초록

This study was performed to investigate whether the spinal cholinergic and serotonergic analgesic systems mediate the relieving effect of electroacupuncture (EA) on oxaliplatin-induced neuropathic cold allodynia in rats. The cold allodynia induced by an oxaliplatin injection (6 mg/kg, i.p.) was evaluated by immersing the rat's tail into cold water ($4^{\circ}C$) and measuring the withdrawal latency. EA stimulation (2 Hz, 0.3-ms pulse duration, 0.2~0.3 mA) at the acupoint ST36, GV3, or LI11 all showed a significant anti-allodynic effect, which was stronger at ST36. The analgesic effect of EA at ST36 was blocked by intraperitoneal injection of muscarinic acetylcholine receptor antagonist (atropine, 1 mg/kg), but not by nicotinic (mecamylamine, 2 mg/kg) receptor antagonist. Furthermore, intrathecal administration of $M_2$ (methoctramine, $10{\mu}g$) and $M_3$ (4-DAMP, $10{\mu}g$) receptor antagonist, but not $M_1$ (pirenzepine, $10{\mu}g$) receptor antagonist, blocked the effect. Also, spinal administration of $5-HT_3$ (MDL-72222, $12{\mu}g$) receptor antagonist, but not $5-HT_{1A}$ (NAN-190, $15{\mu}g$) or $5-HT_{2A}$ (ketanserin, $30{\mu}g$) receptor antagonist, prevented the anti-allodynic effect of EA. These results suggest that EA may have a significant analgesic action against oxaliplatin-induced neuropathic pain, which is mediated by spinal cholinergic ($M_2$, $M_3$) and serotonergic ($5-HT_3$) receptors.

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