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Relationship between the Deposition of Tear Constituents and the Adherence of Candida albicans according to Soft Contact Lens Materials and Pigmentation

소프트콘택트렌즈 재질과 착색에 따른 눈물성분 침착과 칸디다균 흡착의 상관관계

  • Park, So Hyun (Dept. of Optometry, Seoul National University of Science and Technology) ;
  • Kim, So Ra (Dept. of Optometry, Seoul National University of Science and Technology) ;
  • Park, Mijung (Dept. of Optometry, Seoul National University of Science and Technology)
  • 박소현 (서울과학기술대학교 안경광학과) ;
  • 김소라 (서울과학기술대학교 안경광학과) ;
  • 박미정 (서울과학기술대학교 안경광학과)
  • Received : 2016.08.17
  • Accepted : 2016.09.07
  • Published : 2016.09.30

Abstract

Purpose: The aim of this study was to figure out how the characteristics of soft contact lens materials and pigmentation affect the adherence of C. albicans on soft contact lenses pre-deposited with tear constituents. Methods: The adherent number of C. albicans on clear soft contact lenses (hereinafter clear lenses) and circle soft contact lenses (hereinafter circle lenses) made of etafilcon A, hilaiflcon B and nelfilcon A, respectively, was measured before and after the deposition of artificial tear. Also, bacteria adherence on lenses were observed by a scanning electron microscope. Results: Adherence of C. albicans was significantly different according to lens materials. The amount of adsorption was not different between clear lenses and circle lenses made of etafilcon A however, the number of bacteria absorption was bigger in hilafilcon B and nelfilcon A lenses. More absorption of C. albicans was found in the non-pigmented central area compared the pigmented area, and non-pigmented peripheral area has more bacterial absorption than non-pigmented central area. The number of C. albicans decreased in the case that tear protein was pre-deposited. The maintenance of antibacterial activity against C. albicans was different according to lens materials thus, etafilcon A has the longest period of its maintenance. Conclusions: It was revealed that the number of C. albicans was different according to the characteristics of lens materials, pigmentation or non-pigmentation, the pigmented area of soft contact lenses. Thus, it is suggested that the management method should be different according to the adsorption characteristics of C. albicans.

목적: 본 연구에서는 소프트콘택트렌즈의 재질 특성과 착색 여부가 눈물 성분이 침착된 소프트콘택트렌즈에 칸디다균 흡착에 미치는 영향을 알아보았다. 방법: Etafilcon A, hilafilcon B, nelfilcon A 재질의 투명 소프트콘택트렌즈와 써클 소프트콘택트렌즈를 대상으로 하여 인공눈물에 침착시키기 전과 후의 흡착 균 수를 측정하였다. 또한, 주사전자현미경을 통해 렌즈에 흡착된 균을 관찰하였다. 결과: 칸디다균의 흡착은 콘택트렌즈 재질에 따라 통계적으로 유의하게 차이가 있었다. Etafilcon A 재질에서는 투명 소프트콘택트렌즈와 써클 콘택트렌즈간 균 흡착양 차이가 없었으며, hilafilcon B 및 nelfilcon A 재질에서는 써클 소프트콘택트렌즈에 흡착된 균 수가 다소 많았다. 투명 중심부와 착색부를 비교하였을 때 투명 중심부에 칸디다균 흡착이 더 많았으며, 투명 중심부와 투명 주변부를 비교하였을 때 투명 주변부에서의 균 흡착양이 더 많았다. 눈물 단백질이 침착되었을 경우 흡착된 칸디다균의 수가 감소하였으며 눈물 단백질의 칸디다균에 대한 항균력 유지는 재질에 따라 차이가 있어 etafilcon A 재질 렌즈에서 유지 기간이 가장 길었다. 결론: 본 연구에서는 소프트콘택트렌즈의 재질 특성, 착색여부 및 부위에 따라 흡착되는 칸디다균수가 달라진다는 것을 밝혔으며, 칸디다균의 흡착 특성에 따라 관리 방법을 달리해야 할 것을 제안한다.

Keywords

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