Science of Emotion and Sensibility (감성과학)

Korean Society for Emotion and Sensibility (한국감성과학회)
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Brain Activation to Facial Expressions Among Alcoholics

알코올 중독자의 얼굴 표정 인식과 관련된 뇌 활성화 특성

  • Park, Mi-Sook (Department of Rehabilitation Counseling Psychology, Seoul Hanyoung University) ;
  • Lee, Bae Hwan (Department of Physiology, Yonsei University College of Medicine) ;
  • Sohn, Jin-Hun (Department of Psychology, Brain Research Institute, Chungnam National University)
  • 박미숙 (서울한영대학교 재활상담심리학과) ;
  • 이배환 (연세대학교 의과대학 생리학교실) ;
  • 손진훈 (충남대학교 심리학과, 뇌과학 연구소)
  • Received : 2017.05.17
  • Accepted : 2017.10.24
  • Published : 2017.12.31
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Abstract

The purpose of this study was to investigate the neural substrates for recognizing facial expressions among alcoholics by using functional magnetic resonance imaging (fMRI). Abstinent inpatient alcoholics (n=18 males) and demographically similar social drinkers (n=16 males) participated in the study. The participants viewed pictures from the Japanese Female Facial Expression Database (JAFFE) and evaluated intensity of facial expressions. the alcoholics had a reduced activation in the limbic areas including amygdala and hippocampus while recognizing the emotional facial expressions compared to the nonalcoholic controls. On the other hand, the alcoholics showed greater brain activations than the controls in the left lingual (BA 19)/fusiform gyrus, the left middle frontal gyrus (BA 8/9/46), and the right superior parietal lobule (BA 7) during the viewing of emotional faces. In sum, specific brain regions were identified that are associated with recognition of facial expressions among alcoholics. The implication of the present study could be used in developing intervention for alcoholism.

본 연구는 자기공명영상 기법을 이용하여 알코올 중독자의 정서 인식과 관련된 뇌 활성화 특성을 관찰하였다. 입원치료 중인 알코올 중독자 18명과 이들과 나이, 성별, 교육 수준 등이 유사한 비중독자 16명이 실험에 참여하였다. 참여자들은 뇌 영상 촬영 동안에 얼굴 사진을 보고 얼굴 표정 정서의 강도를 평정하였다. 연구 결과, 행동 반응에서는 알코올 중독자와 비중독자 간에 유의한 차이는 나타나지 않았다. 뇌 반응 결과, 알코올 집단에서는 비중독자 집단과 비교하여 얼굴 표정 정서 인식 동안에 정서 처리와 관련된 편도체/해마는 더 적게 활성화되었으며, 얼굴 정보 처리와 관련된 방추이랑, 시 공간 탐색과 관련된 이마엽 및 마루엽 영역은 더 크게 활성화되었다. 반면, 알코올 집단에서 혀이랑/방추이랑(BA 19), 시각적 탐색에 관여하는 가운데이마이랑(BA 8/9/46), 그리고 시공간적 정보 처리에 관여하는 위마루소엽(BA 7)이 더 크게 활성화 되었다. 본 연구를 통해 알코올 중독자의 정서 인식과 관련된 뇌 활성화 특성을 확인할 수 있었다.

Keywords

References

  1. Adolphs, R., Baron-Cohen, S., & Tranel, D. (2002). Impaired recognition of social emotions following amygdala damage. Journal of Cognitive Neuroscience, 14(8), 1264-1274. DOI: 10.1162/089892902760807258
  2. Aggleton, J. P. (2000). The amygdala: A functional analysis (2nd ed.). Oxford, New York: Oxford University Press.
  3. Breiter, H. C., Etcoff, N. L., Whalen, P. J., Kennedy, W. A., Rauch, S. L., Buckner, R. L., Strauss, M. M.,, Hyman, S. E., & Rosen, B. R. (1996). Response and habituation of the human amygdala during visual processing of facial expression. Neuron, 17(5), 875-887. DOI: 10.1016/S0896-6273(00)80219-6
  4. Bruce, C. J., & Goldberg, M. E. (1985). Primate frontal eye fields. I. Single neurons discharging before saccades. Journal of Neurophysiology, 53(3), 603-635. https://doi.org/10.1152/jn.1985.53.3.603
  5. Carr, L., Iacoboni, M., Dubeau, M. C., Mazziotta, J. C., & Lenzi, G. L. (2003). Neural mechanisms of empathy in humans: a relay from neural systems for imitation to limbic areas. Proceedings of the Nation Academy of Science, 100(9), 5497-5502. DOI: 10.1073/pnas.0935845100
  6. Cermak, L. S., Verfaellie, M., Letourneau, L., Blackford, S., Weiss S., & Numan, B. (1989). Verbal and nonverbal right hemisphere processing by chronic alcoholics. Alcoholism: Clinical and Experimental Research, 13(5), 611-617. DOI: 10.1111/j.1530-0277.1989.tb00391.x
  7. Darwin, C. (1872). The expression of emotions in man and animals. Chicago, University of Chicago Press.
  8. Fitzgerald, D. A., Angstadt, M., Jelsone, L. M., Nathan, P. J., & Phan, K. L. (2006). Beyond threat: amygdala reactivity across multiple expressions of facial affect. Neuroimage, 30(4), 1441-1448. DOI: 10.1016/j.neuroimage.2005.11.003
  9. Fitzpatrick, L. E., Jackson, M., & Crowe, S. F. (2008). The relationship between alcoholic cerebellar degeneration and cognitive and emotional functioning. Neuroscience & Biobehavioral Reviews, 32(3), 466-485. DOI: 10.1016/j.neubiorev.2007.08.004
  10. Frigerio, E., Burt, D. M., Montagne, B., Murray, L. K., & Perrett, D. I. (2002). Facial affect perception in alcoholics. Psychiatry Research, 113(1), 161-171. DOI: 10.1016/S0165-1781(02)00244-5
  11. Glahn, D. C., Lovallo, W. R., & Fox, P. T. (2007). Reduced amygdala activation in young adults at high risk of alcoholism: Studies from the Oklahoma family health patterns project. Biological Psychiatry, 61(11), 1306-1309. DOI: 10.1016/j.biopsych.2006.09.041
  12. Gur, R. C., Schroeder, L., Turner, T., McGrath, C., Chan, R. M, Turetsky, B. I, Alsop, D., Maldjian, J., & Gur, R. E. (2002). Brain activation during facial emotion processing. Neuroimage, 16(3 Pt 1), 651-662. DOI: 10.1006/nimg.2002.1097
  13. Haxby, J. V., Hoffman, E. A., & Gobbini, M. I. (2000). The distributed human neural system for face perception. Trends in Cognitive Science, 4(6), 223-233. DOI: 10.1016/S1364-6613(00)01482-0
  14. Hubl, D., Bolte, S., Feineis-Matthews, S., Lanfermann, H., Federspiel, A., Strik, W., Poustka, F., & Dierks, T. (2003). Functional imbalance of visual pathways indicates alternative face processing strategies in autism. Neurology, 61(9), 1232-1237. DOI: 10. 1212/ 01. WNL. 0000091862. 22033. 1A https://doi.org/10.1212/01.WNL.0000091862.22033.1A
  15. Iacoboni, M., Woods, R. P., Brass, M., Bekkering, H., Mazziotta, J. C., & Rizzolatti, G. (1999). Cortical mechanisms of human imitation. Science, 286(5449), 2526-2528. DOI: 10.1126/science.286.5449.2526
  16. Kiehl, K. A., Smith, A. M., Hare, R. D., Mendrek, A., Forster, B. B., Brink, J., & Liddle, P. F. (2001). Limbic abnormalities in affective processing by criminal psychopaths as revealed by functional magnetic resonance imaging. Biological Psychiatry, 50(9), 677-684. DOI: 10.1016/S0006-3223(01)01222-7
  17. Kim, J. S. (1998). A understanding about recovery process of alcoholism. Journal of the Korean Academy of Family Medicine, 19(5 Suppl), 304-312.
  18. Kohler, C. G., Hoffman, L. J., Eastman, L. B., Healey, K., & Moberg, P. J. (2011). Facial emotion perception in depression and bipolar disorder: A quantitative review. Psychiatry Research, 188(3), 303-309. DOI: 10.1016/j.psychres.2011.04.019
  19. Lee, D. K., Shin, J. K., Yun, S. M., Byun, W. T. (2000). A reliability and validity study of the Korean Version of the Alcohol Dependence Scale in alcoholics. Journal of Academy of Addiction Psychiatry, 4, 30-37.
  20. Leslie, K. R., Johnson-Frey, S. H., & Grafton, S. T. (2004). Functional imaging of face and hand imitation: towards a motor theory of empathy. NeuroImage, 21(2), 601-607. DOI: 10.1016/j.neuroimage.2003.09.038
  21. Lindquist, K. A., Wager, T. D., Kober, H., Bliss-Moreau, E., & Barrett, L. F. (2012). The brain basis of emotion: a meta-analytic review. Behavioral and Brain Sciences, 35(3), 121-143. DOI: 10.1017/S0140525X11000446
  22. Litt, M. D., Cooney, N. L., Kadden, R. M., & Gaupp, L. (1990). Reactivity to alcohol cues and induced mood in alcoholics. Addictive Behaviors, 15(2), 137-146. DOI: 10.1016/0306-4603(90)90017-R
  23. Lyons, M. J., Akamatsu, S., Kamachi, M., & Gyoba, J. (1998 April). Coding Facial Expressions with Gabor Wavelets. Third IEEE Proceedings of International Conference on Automatic Face and Gesture Recognition, IEEE Computer Society, Nara Japan. DOI: 10.1109/AFGR.1998.670949
  24. Marinkovic, K., Oscar‐Berman, M., Urban, T., O'Reilly, C. E., Howard, J. A., Sawyer, K., & Harris, G. J. (2009). Alcoholism and dampened temporal limbic activation to emotional faces. Alcoholism: Clinical and Experimental Research, 33(11), 1880-1892. DOI: 10.1111/j.1530-0277.2009.01026.x
  25. Marsh, A. A., & Blair, R. J. R. (2008). Deficits in facial affect recognition among antisocial populations: a meta-analysis. Neuroscience & Biobehavioral Reviews, 32(3), 454-465. DOI: 10.1016/j.neubiorev.2007.08.003
  26. Marsh, A. A., Finger, E. C., Mitchell, D. G., Reid, M. E., Sims, C., Kosson, D. S., Towbin, K. E., Leibenluft, E., Pine, D. S., & Blair, R. J. (2008). Reduced amygdala response to fearful expressions in children and adolescents with callous-unemotional traits and disruptive behavior disorders. American Journal of Psychiatry, 165(6), 712-720. DOI: 10.1176/appi.ajp.2007.07071145
  27. Moselhy, H. F., Georgiou, G., & Kahn, A. (2001). Frontal lobe changes in alcoholism: A review of the literature. Alcohol Alcoholism, 36(5), 357-368. DOI: 10.1093/alcalc/36.5.357
  28. Oscar-Berman, M., Hancock, M., Mildworf, B., Hutner, N., & Weber D. A. (1990). Emotional perception and memory in alcoholism and aging. Alcoholism: Clinical and Experimental Research, 14(3), 383-393. DOI: 10.1111/j.1530-0277.1990.tb00491.x
  29. Park, B. K., Kim, J. S., Lee, D. B. (2000). Comparison of four alcoholism screening tools based on sensitivity and specificity for DSM-IV criteria. Journal of the Korean Academy of Family Medicine, 21(11), 1427-1435.
  30. Park, M. S., Kim, S. H., Sohn, S., Kim, G. J., Kim, Y. K., & Sohn, J. H. (2015). Brain activation during processing of angry facial expressions in patients with alcohol dependency. Journal of Physiological Anthropology, 34(1), 6. DOI: 10.1186/s40101-015-0046-6
  31. Petrides, M. (1987). Conditional learning and the primate frontal cortex. In E. Perecman (Ed.), The frontal Lobes Revisited, New York: IRBN press, 91-108.
  32. Philippot, P., Kornreich, C., Blairy, S., Baert, I., Den Dulk, A., Le Bon, O., Streel, E., Hess, U., Pelc, I., & Verbanck, P. (1999). Alcoholics' deficits in the decoding of emotional facial expression. Alcoholism: Clinical and Experimental Research, 23(6), 1031-1038. DOI: 10.1111/j.1530-0277.1999.tb04221.x
  33. Prvulovic, D., Hubl, D., Sack, A. T., Melillo, L., Maurer, K., Frölich, L., Lanfermann, H., Zanella, F.E., Goebel, R., Linden, D. E., & Dierks, T. (2002). Functional imaging of visuospatial processing in Alzheimer's disease. Neuroimage, 17(3), 1403-1414. DOI: 10.1006/nimg.2002.1271
  34. Salloum, J. B., Ramchandani, V. A., Bodurka, J., Rawlings, R., Momenan, R., George, D., & Hommer, D. W. (2007). Blunted rostral anterior cingulate response during a simplified decoding task of negative emotional facial expressions in alcoholic patients. Alcoholism: Clinical and Experimental Research, 31(9), 1490-1504. DOI: 10.1111/j.1530-0277.2007.00447.x
  35. Townshend, J. M., & Duka, T. (2003). Mixed emotions: alcoholics' impairments in the recognition of specific emotional facial expressions. Neuropsychologia, 41(7), 773-782. DOI: 10.1016/S0028-3932(02)00284-1
  36. Uekermann, J., & Daum, I. (2008). Social cognition in alcoholism: a link to prefrontal cortex dysfunction? Addiction, 103(5), 726-735. DOI: 10.1111/j.1360-0443.2008.02157.x
  37. Winston, J. S., O'Doherty, J., & Dolan, R. J. (2003). Common and distinct neural responses during direct and incidental processing of multiple facial emotions. Neuroimage, 20(1), 84-97. DOI: 10.1016/S1053-8119(03)00303-3
  38. Wojciulik, E., & Kanwisher, N. (1999). The generality of parietal involvement in visual attention. Neuron, 23(4), 747-764. DOI: 10.1016/S0896-6273(01)80033-7