Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Scutellaria baicalensis Extract on Skin Lesion of Contact Dermatitis induced by DNFB in Mice

황금 추출물이 생쥐에 유발된 접촉피부염의 피부 증상에 미치는 영향

  • Yang, Beodul (School of Korean medicine, Pusan National University) ;
  • Kim, Sura (School of Korean medicine, Pusan National University) ;
  • Choi, Chan Hun (College of Korean Medicine, Dongshin University) ;
  • Jeoung, Hyun Woo (College of Korean Medicine, Dongshin University) ;
  • Kim, Hyungwoo (School of Korean medicine, Pusan National University)
  • 양버들 (부산대학교 한의학전문대학원) ;
  • 김수라 (부산대학교 한의학전문대학원) ;
  • 최찬헌 (동신대학교 한의과대학) ;
  • 정현우 (동신대학교 한의과대학) ;
  • 김형우 (부산대학교 한의학전문대학원)
  • Received : 2016.10.26
  • Accepted : 2016.12.05
  • Published : 2017.02.25
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Abstract

Scutellaria baicalensis Georgi is one of major herbs used to treat patients with skin diseases diagnosed by wind-heat syndrome. This study was designed to investigate the effects of Scutellaria baicalensis Extract (SBE) on skin lesion of Contact dermatitis (CD) in mice. We investigated the effects of SBE on skin thickness, skin lesions, erythema index and melanin index in vivo. The effects on body weights and spleen/body weight ratio were also investigated in mice with CD induced by topical application of 1-Fluoro-2,4-dinitrofluorobenzene (DNFB). In our results, topical application of SBE lowered skin thickness significantly. In addition, SBE ameliorated skin lesions such as erythema, exudate and petechia in mice with CD. SBE also inhibited erythema index elevated by DNFB significantly. finally, SBE did not affect body weight and spleen/body weight ratio. In conclusion, these data imply that SBE can ameliorate skin lesion of CD such as erythema, exudate and petechia, and be used to treat CD patients with relative safety.

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References

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