Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Review of Experimental Researches on Gastrointestinal Activity of Agastache rugosa (Fisch. & C. A. Mey.) Kuntze and Pogostemon cablin (Blanco) Benth.

곽향(藿香) 및 광곽향(廣藿香)의 위장관 효능에 대한 실험연구 고찰

  • Jerng, Ui Min (Clinical Research Division, Korea Institute of Oriental Medicine) ;
  • Oh, Yong Taek (Department of Diagnostics, College of Korean Medicine, Woosuk University) ;
  • Kim, Jung Hoon (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 정의민 (한국한의학연구원 임상연구부) ;
  • 오용택 (우석대학교 한의과대학 진단학교실) ;
  • 김정훈 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2017.01.18
  • Accepted : 2017.04.20
  • Published : 2017.04.25
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Abstract

The pharmacological rationale of Agastache rugosa (AR) or Pogostemon cablin (PC), which have been used in traditional Korean medicine to treat dampness pattern or syndrome in gastrointestinal tract, was investigated on the gastrointestinal disorders. In-vivo model studies that examined the effect on the gastrointestinal disorders of AR or PC were collected. They were classified into disease-induced in-vivo models or non-disease in vivo models. The target disease, animal species, induction method, administration, and outcomes (changes in morphological and histological parameter, or blood and fluid) of each study were analyzed. The therapeutic mechanism of AR or PC extract was evaluated by the induced diseases and the changes in outcomes. There were contradictory reports on gastrointestinal motility of AR or PC in disease non-disease in-vivo model. AR or PC inhibited gastrointestinal motility in disease model of increased gastrointestinal motility, while promoted motility in disease model of decreased gastrointestinal motility. AR or PC also inhibited inflammatory changes in gastrointestinal inflammation model. These results suggest that the bidirectional regulation of gastrointestinal motility and the improvement of gastrointestinal inflammatory disorders might underpin traditional therapeutic effect of AR or PC, that is effect to resolve dampness of gastrointestinal tract.

Keywords

References

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