동의생리병리학회지 (Journal of Physiology & Pathology in Korean Medicine)

  • 제31권6호
  • /
  • Pages.313-327
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  • 2017
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  • 1738-7698(pISSN)
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  • 2288-2529(eISSN)
대한동의생리학회·한의병리학회 ( The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine)
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네트워크 약리학을 통한 당뇨병성 신병증에서의 황기와 산수유의 활성 성분 및 잠재 타겟 예측

Network Pharmacology: Prediction of Astragalus Membranaceus' and Cornus Officinalis' Active Ingredients and Potential Targets to Diabetic Nephropathy

  • 이근현 (혜민한의원) ;
  • 이하린 (부산대학교 의학전문대학원 신장내과) ;
  • 정한솔 (부산대학교 한의학전문대학원 응용의학부) ;
  • 신상우 (부산대학교 한의학전문대학원 응용의학부)
  • Lee, Keun-Hyeun (Hemin Traditional Korean Medical Clinic) ;
  • Rhee, Harin (Department of Internal Medicine, Pusan National University School of Medicine) ;
  • Jeong, Han-Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Shin, Sang Woo (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
  • 투고 : 2017.04.03
  • 심사 : 2017.12.21
  • 발행 : 2017.12.25
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초록

The purpose of this study is to predict the effects of macroscopic and integrative therapies by finding active ingredients, potential targets of Astragalus membranaceus (Am) and Cornus officinalis (Co) for diabetic nephropathy. We have constructed network pharmacology-based systematic and network methodology by system biology, chemical structure, chemogenomics. We found several active ingredients of Astragalus membranaceus (Am) and Cornus officinalis (Co) that were speculated to bind to specific receptors which had been known to have a role in the progression of diabetic nephropathy. Four components of Am and eleven components of Co could bind to iNOS; two ingredients of Am and six ingredients of Co could docking to cGB-PDE; one component of Am and nine components of Co could bind to ACE; three ingredients of Co with neprilysin; three components of Co with ET-1 receptor; four ingredients of Am and fourteen ingredients of Co with mineralocorticoid receptor; one component of Am and seven components of Co with interstitial collagenase; one ingredient of Am and ten ingredients of Co with membrane primary amine oxidase; one component of Am and four components of Co with JAK2; two ingredients of Am and one ingredient of Co with MAPK 12; one component of Am and five components of Co could docking to TGF-beta receptor type-1. From this work we could speculate that the possible mechanisms of Am and Co for diabetic nephropathy are anti-inflammatory, antioxidant and antihypertensive effects.

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