Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Inhibitory Effects of Banhasasim-tang Extracts on Cisplatin-induced Body Weight Decrease in Mouse Model

시스플라틴 유도 체중감소에 대한 반하사심탕 추출물의 방어효과

  • Kim, Ha Rim (Center for Metabolic Function Regulation, School of Medicine, Wonkwang University) ;
  • Kim, Mi Seong (Center for Metabolic Function Regulation, School of Medicine, Wonkwang University) ;
  • Lee, Young Rae (Department of Oral Biochemistry, School of Dentistry, Wonkwang University) ;
  • Ryu, Do Gon (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Lim, Chan Han (Department of Physiology, School of Korean Medicine, Wonkwang University) ;
  • Kim, Byung Sook (Department of Hotel Culinary Arts & Nutrition, Jeonbuk Science College) ;
  • Lee, Geum-San (Department of Herbology, School of Korean Medicine, Wonkwang University) ;
  • Kwon, Kang Beom (Department of Physiology, School of Korean Medicine, Wonkwang University)
  • 김하림 (원광대학교 의과대학 대사기능제어연구센터) ;
  • 김미성 (원광대학교 의과대학 대사기능제어연구센터) ;
  • 이영래 (원광대학교 치과대학 구강생화학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실) ;
  • 임찬한 (원광대학교 한의과대학 생리학교실) ;
  • 김병숙 (전북과학대학교 호텔조리영양과) ;
  • 이금산 (원광대학교 한의과대학 본초학교실) ;
  • 권강범 (원광대학교 한의과대학 생리학교실)
  • Received : 2017.11.22
  • Accepted : 2017.12.08
  • Published : 2017.12.25
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Abstract

In this study, Banhasasim-tang extracts (BSTE) have an inhibitory effects on cisplatin-induced decrease of body weights in two mouse model. Cisplatin is the most widely used anticancer drug for treatment of various cancer. However, cisplatin treatment to cancer patients leads to many side effects such as nausea, vomiting and body weight decrease. BSTE has been used to decrease digestive disorders in South Korea. We hypothesize that BSTE improve the cisplatin-induced side effects in mouse models. We found that pre- and co-administration of BSTE inhibited decreases of body weights and food intake by cisplatin in mouse models. But BSTE had no synergistic effects for tumor shrinkage by cisplatin in xenograft model. Collectively, our data suggest that BSTE have great potential as a agent for having decrease effects on side effects by cisplatin in cancer patients.

Keywords

References

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