The Korean Journal of Physiology and Pharmacology

  • 제21권6호
  • /
  • Pages.617-623
  • /
  • 2017
  • /
  • 1226-4512(pISSN)
  • /
  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
권호 표지
DOI QR코드

DOI QR Code

Taurine relaxes human radial artery through potassium channel opening action

  • Ulusoy, Kemal Gokhan (Department of Medical Pharmacology, Gulhane Faculty of Medicine, University of Health Sciences) ;
  • Kaya, Erkan (Department of Cardiovascular Surgery, Gaziantep Faculty of Medicine, Gaziantep University) ;
  • Karabacak, Kubilay (Department of Cardiovascular Surgery, Gulhane Faculty of Medicine, University of Health Sciences) ;
  • Seyrek, Melik (Department of Medical Pharmacology, Gulhane Faculty of Medicine, University of Health Sciences) ;
  • Duvan, ibrahim (Department of Cardiovascular Surgery, Guven Hospital) ;
  • Yildirim, Vedat (Department of Anesthesiology, Gulhane Faculty of Medicine, University of Health Sciences) ;
  • Yildiz, Oguzhan (Department of Medical Pharmacology, Gulhane Faculty of Medicine, University of Health Sciences)
  • 투고 : 2017.04.09
  • 심사 : 2017.06.01
  • 발행 : 2017.11.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

The vascular actions and mechanisms of taurine were investigated in the isolated human radial artery (RA). RA rings were suspended in isolated organ baths and tension was recorded isometrically. First, a precontraction was achieved by adding potassium chloride (KCl, 45 mM) or serotonin (5-hydroxytryptamine, 5-HT, $30{\mu}M$) to organ baths. When the precontractions were stable, taurine (20, 40, 80 mM) was added cumulatively. Antagonistic effect of taurine on calcium chloride ($10{\mu}M$ to 10 mM) -induced contractions was investigated. Taurine-induced relaxations were also tested in the presence of the $K^+$ channel inhibitors tetraethylammonium (1 mM), glibenclamide ($10{\mu}M$) and 4-aminopyridine (1 mM). Taurine did not affect the basal tone but inhibited the contraction induced by 5-HT and KCl. Calcium chloride-induced contractions were significantly inhibited in the presence of taurine (20, 40, 80 mM) (p<0.05). The relaxation to taurine was inhibited by tetraethylammonium (p<0.05). However, glibenclamide and 4-aminopyridine did not affect taurine -induced relaxations. Present experiments show that taurine inhibits 5-HT and KCl -induced contractions in RA, and suggest that large conductance $Ca^{2+}$-activated $K^+$ channels may be involved in taurine -induced relaxation of RA.

키워드

참고문헌

  1. Huxtable RJ. Physiological actions of taurine. Physiol Rev. 1992;72:101-163. https://doi.org/10.1152/physrev.1992.72.1.101
  2. Oja SS, Saransaari P. Pharmacology of taurine. Proc West Pharmacol Soc. 2007;50:8-15.
  3. Militante JD, Lombardini JB. Treatment of hypertension with oral taurine: experimental and clinical studies. Amino Acids. 2002;23:381-393. https://doi.org/10.1007/s00726-002-0212-0
  4. Kohashi N, Katori R. Decrease of urinary taurine in essential hypertension. Jpn Heart J. 1983;24:91-102. https://doi.org/10.1536/ihj.24.91
  5. Abebe W, Mozaffari MS. Role of taurine in the vasculature: an overview of experimental and human studies. Am J Cardiovasc Dis. 2011;1:293-311.
  6. Franconi F, Giotti A, Manzini S, Martini F, Stendardi I, Zilletti L. The effect of taurine on high potassium- and noradrenaline-induced contraction in rabbit ear artery. Br J Pharmacol. 1982;75:605-612. https://doi.org/10.1111/j.1476-5381.1982.tb09180.x
  7. Ristori MT, Verdetti J. Effects of taurine on rat aorta in vitro. Fundam Clin Pharmacol. 1991;5:245-258. https://doi.org/10.1111/j.1472-8206.1991.tb00716.x
  8. Li N, Sawamura M, Nara Y, Ikeda K, Yamori Y. Direct inhibitory effects of taurine on norepinephrine-induced contraction in mesenteric artery of stroke-prone spontaneously hypertensive rats. Adv Exp Med Biol. 1996;403:257-262.
  9. Niu LG, Zhang MS, Liu Y, Xue WX, Liu DB, Zhang J, Liang YQ. Vasorelaxant effect of taurine is diminished by tetraethylammonium in rat isolated arteries. Eur J Pharmacol. 2008;580:169-174. https://doi.org/10.1016/j.ejphar.2007.10.039
  10. Liu Y, Niu L, Zhang W, Cui L, Zhang X, Liang Y, Zhang M. Effects of taurine on contractions of the porcine coronary artery. Pharmacol Rep. 2009;61:681-689. https://doi.org/10.1016/S1734-1140(09)70120-3
  11. Karabacak K, Kaya E, Ulusoy KG, Seyrek M, Kurtoglu M, Doganci S, Yildirim V, Yildiz O, Demirkilic U. Effects of taurine on contractions of human internal mammary artery: a potassium channel opening action. Eur Rev Med Pharmacol Sci. 2015;19:1498-1504.
  12. He GW. Verapamil plus nitroglycerin solution maximally preserves endothelial function of the radial artery: comparison with papaverine solution. J Thorac Cardiovasc Surg. 1998;115:1321-1327. https://doi.org/10.1016/S0022-5223(98)70215-6
  13. Nisanoglu V, Battaloglu B, Ozgur B, Eroglu T, Erdil N. Topical vasodilators for preventing radial artery spasm during harvesting for coronary revascularization: comparison of 4 agents. Heart Surg Forum. 2006;9:E807-812. https://doi.org/10.1532/HSF98.20061070
  14. Yildiz O, Seyrek M, Gul H. Pharmacology of arterial grafts for coronary artery bypass surgery. In: Aronow WS, editor. Artery bypass. Croatia: Intech; 2013. p.251-276.
  15. Mussa S, Choudhary BP, Taggart DP. Radial artery conduits for coronary artery bypass grafting: current perspective. J Thorac Cardiovasc Surg. 2005;129:250-253. https://doi.org/10.1016/j.jtcvs.2004.07.040
  16. Possati G, Gaudino M, Prati F, Alessandrini F, Trani C, Glieca F, Mazzari MA, Luciani N, Schiavoni G. Long-term results of the radial artery used for myocardial revascularization. Circulation. 2003;108:1350-1354. https://doi.org/10.1161/01.CIR.0000087402.13786.D0
  17. Seyrek M, Yildiz O, Ulusoy HB, Yildirim V. Testosterone relaxes isolated human radial artery by potassium channel opening action. J Pharmacol Sci. 2007;103:309-316. https://doi.org/10.1254/jphs.FP0060883
  18. Yildiz O, Seyrek M, Un I, Gul H, Candemir G, Yildirim V. The relationship between risk factors and testosterone-induced relaxations in human internal mammary artery. J Cardiovasc Pharmacol. 2005;45:4-7. https://doi.org/10.1097/00005344-200501000-00002
  19. Guven G, Seyrek M, Vural IM, Cehreli ZC, Yildiz O. Vasodilatory effect of hydroxyethyl methacrylate and triethylene glycol dimethacrylate in rat aorta through calcium antagonistic action. J Endod. 2011;37:353-357. https://doi.org/10.1016/j.joen.2010.11.038
  20. Quayle JM, McCarron JG, Brayden JE, Nelson MT. Inward rectifier $K^{+}$ currents in smooth muscle cells from rat resistance-sized cerebral arteries. Am J Physiol. 1993;265:C1363-1370. https://doi.org/10.1152/ajpcell.1993.265.5.C1363
  21. Xue WX, Zhang MS, Niu LG, Liu Y, Liang YQ. Vasodilation effects and mechanism of taurine on rat thoracic aortas. Chin J Pharmacol Toxicol. 2007;21:23-27.
  22. Tosun M, Paul RJ, Rapoport RM. Intracellular $Ca^{2+}$ elevation and contraction due to prostaglandin F2alpha in rat aorta. Eur J Pharmacol. 1997;340:203-208. https://doi.org/10.1016/S0014-2999(97)01415-5
  23. Xue W, Zhang M, Li J, Wu D, Niu L, Liang Y. Effects of taurine on aortic rings isolated from fructose-fed insulin resistance Sprague-Dawley rat are changed. Cardiovasc Drugs Ther. 2008;22:461-468. https://doi.org/10.1007/s10557-008-6124-9
  24. Briel G, Gylfe E, Hellman B, Neuhoff V. Microdetermination of free amino acids in pancreatic islets isolated from obese-hyperglycemic mice. Acta Physiol Scand. 1972;84:247-253. https://doi.org/10.1111/j.1748-1716.1972.tb05175.x
  25. Moran J, Hernandez-Pech X, Merchant-Larios H, Pasantes-Morales H. Release of taurine in apoptotic cerebellar granule neurons in culture. Pflugers Arch. 2000;439:271-277. https://doi.org/10.1007/s004240050940
  26. Song D, O'Regan MH, Phillis JW. Mechanisms of amino acid release from the isolated anoxic/reperfused rat heart. Eur J Pharmacol. 1998;351:313-322. https://doi.org/10.1016/S0014-2999(98)00318-5
  27. Lambert IH, Kristensen DM, Holm JB, Mortensen OH. Physiological role of taurine-from organism to organelle. Acta Physiol (Oxf). 2015;213:191-212. https://doi.org/10.1111/apha.12365
  28. Schaffer SW, Jong CJ, Ito T, Azuma J. Effect of taurine on ischemiareperfusion injury. Amino Acids. 2014;46:21-30. https://doi.org/10.1007/s00726-012-1378-8

피인용 문헌

  1. The Effects of Oral Taurine on Resting Blood Pressure in Humans: a Meta-Analysis vol.20, pp.9, 2017, https://doi.org/10.1007/s11906-018-0881-z
  2. Potassium channels in vascular smooth muscle: a pathophysiological and pharmacological perspective vol.33, pp.5, 2017, https://doi.org/10.1111/fcp.12461
  3. Using lectures to identify student misconceptions: a study on the paradoxical effects of hyperkalemia on vascular smooth muscle vol.44, pp.1, 2020, https://doi.org/10.1152/advan.00030.2019
  4. Metabolism of vascular smooth muscle cells in vascular diseases vol.319, pp.3, 2017, https://doi.org/10.1152/ajpheart.00220.2020