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Anti-allergic Effects of Jagamcho-tang in Ovalbumin-induced Atopic Dermatitis Mouse Model

Ovalbumin으로 유발된 아토피피부염 마우스 모델에서 자감초탕(炙甘草湯)의 항알레르기 효과

  • Noh, Hyeon-Min (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University) ;
  • Park, Sung-gu (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University) ;
  • Kim, Wonjeong (Traditional Korean Medical Dermatology Institute, Wonkwang University) ;
  • Jo, Eun-Hee (Department of Acupunture and Moxibustion, Wonkwang University) ;
  • Ki, Hyeon-Hui (Department of Medicine, Chonbuk National University & Medical Science Institute) ;
  • Kim, Dae-Ki (Department of Medicine, Chonbuk National University & Medical Science Institute) ;
  • Park, Min-Cheol (Department of Korean Medical Ophthalmology, Otolaryngology & Dermatology, Wonkwang University)
  • 노현민 (원광대학교 한의과대학 한방안이비인후피부과) ;
  • 박승구 (원광대학교 한의과대학 한방안이비인후피부과) ;
  • 김원정 (원광대학교 한방피부과학연구소) ;
  • 조은희 (원광대학교 한의과대학 침구과) ;
  • 기현희 (전북대학교 의과대학 및 의과학연구소) ;
  • 김대기 (전북대학교 의과대학 및 의과학연구소) ;
  • 박민철 (원광대학교 한의과대학 한방안이비인후피부과)
  • Received : 2017.06.23
  • Accepted : 2017.10.19
  • Published : 2017.10.25

Abstract

Activated T helper 2 (Th2) immune function is hallmark of various allergic diseases. We investigated the anti-allergic effect of Jagamcho-tang extract(JE) on ovalbumin(OVA)-induced atopic dermatitis mice model and OVA-stimulated splenocytes isolated from the mice. Mice were intraperitoneally injected OVA/alum solution 2 times at interval of 14 days, followed by oral administration of JE for 7 days. After administration, mice were subcutaneously injected with OVA in ear. JE treatment reduced ear swelling and infiltration of inflammatory cells in ear. Serum levels of interleukin(IL)-4 and immunoglobulins, such as total-IgE and OVA-specific IgE, were decreased in JE treated group. Furthermore, JE treatment decreased OVA-induced Th2-associated cytokines like IL-4, IL-5 and IL-13 mRNA levels in splenocytes. In conclusion, JE reduced allergic immune response via IgE production and Th2 response in OVA-sensitized mice, suggesting that JE could be useful prescription for allergic diseases including atopic dermatitis.

Keywords

References

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