Pediatric Gastroenterology, Hepatology & Nutrition

  • 제21권1호
  • /
  • Pages.28-33
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  • 2018
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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A Synbiotic Infant Formula with High Magnesium Content Improves Constipation and Quality of Life

  • 투고 : 2017.09.12
  • 심사 : 2017.10.07
  • 발행 : 2018.01.15
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초록

Purpose: To evaluate the efficacy of synbiotic formula with partial whey hydrolysate and high magnesium content in infants presenting with functional constipation. Methods: Sixty-five infants with functional constipation were included. Forty infants were treated during one month with parental reassurance and the intervention formula and were compared to a control group of 25 infants treated with parental reassurance only. Parents completed a quality of life (QoL) questionnaire at baseline and during the last week of the study. Results: At inclusion, stool characteristics and QoL were similar in both groups. The control group was slightly older than the intervention group ($7.5{\pm}3.9$ vs. $6.2{\pm}3.6$ weeks). At onset, stool composition was "hard and tight" (Bristol stool scale 1 and 2) in all infants. After one month, stool composition remained unchanged in the control group except in two infants that developed "creamy" stools (Bristol stool scale type 3 and 4). In the intervention group, stools remained "hard and tight" in 27.5%, and became "creamy" in 47.5%, "loose" (Bristol stool scale type 5) in 22.5% and "watery" (Bristol stool type 6 and 7) in 2.5%. The benefit of the intervention formula was estimated to be "very important" in 70%. The median scores for QoL improved significantly in the intervention group for all parameters and for one in the control group. Conclusion: The intervention formula significantly improved functional constipation resulting in a better QoL of the parents and infants.

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참고문헌

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  2. Non-pharmacologic approach to pediatric constipation vol.59, pp.None, 2018, https://doi.org/10.1016/j.ctim.2021.102711
  3. An Observational Real-Life Study with a New Infant Formula in Infants with Functional Gastro-Intestinal Disorders vol.13, pp.10, 2018, https://doi.org/10.3390/nu13103336