Asian-Australasian Journal of Animal Sciences

  • 제31권2호
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  • Pages.163-166
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  • 2018
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Genetic association of swine leukocyte antigen class II haplotypes and body weight in Microminipigs

  • Matsubara, Tatsuya (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Takasu, Masaki (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Imaeda, Noriaki (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Nishii, Naohito (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Takashima, Satoshi (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Nishimura, Takashi (Fuji Micra Inc.) ;
  • Nishimura, Toshiaki (Fuji Micra Inc.) ;
  • Shiina, Takashi (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Ando, Asako (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Kitagawa, Hitoshi (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University)
  • 투고 : 2017.05.02
  • 심사 : 2017.07.28
  • 발행 : 2018.02.01
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초록

Objective: Microminipigs are a novel animal model with extensive applications in laboratory studies owing, in part, to their extremely small body sizes. In this study, the relationship between swine leukocyte antigen (SLA) class II haplotype and body weight was evaluated in the Microminipig population. Methods: A total of 1,900 haplotypes, covering SLA class II haplotypes Lr-0.7, Lr-0.23, Lr-0.17, Lr-0.37, Lr-0.16, Lr-0.11, Lr-0.13, and Lr-0.18, were analyzed in 950 piglets. Birth weights and weights on postnatal day 50 were examined in piglets with eight different SLA class II haplotypes. Results: The mean birth weight of piglets with the Lr-0.23 haplotype (0.415 kg, n = 702) was significantly lower than that of piglets with Lr-0.17 (0.445 kg, n = 328) and Lr-0.37 (0.438 kg, n = 383) haplotypes. At postnatal day 50, the mean body weight of piglets with the Lr-0.23 haplotype (3.14 kg) was significantly lower than that of piglets with the Lr-0.13 haplotype (3.46 kg, p<0.01). There were no significant differences in daily gains (DGs) among the eight haplotypes. However, piglets with the Lr-0.11 and -0.18 haplotype combination or any heterozygous haplotype combinations containing Lr-0.23 had significantly lower DGs than those of piglets with the Lr-0.18, 0.37 haplotype combination. Conclusion: Piglets with the Lr-0.23 haplotype had relatively low body weights at birth and on postnatal day 50 and slightly lower DGs than those of piglets with other haplotypes. Therefore, the Lr-0.23 SLA class II haplotype may be a suitable marker for the selective breeding of Microminipigs with small body sizes.

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참고문헌

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피인용 문헌

  1. Genetic Association between Swine Leukocyte Antigen Class II Haplotypes and Reproduction Traits in Microminipigs vol.8, pp.8, 2018, https://doi.org/10.3390/cells8080783
  2. Importance of the Major Histocompatibility Complex (Swine Leukocyte Antigen) in Swine Health and Biomedical Research vol.8, pp.None, 2018, https://doi.org/10.1146/annurev-animal-020518-115014
  3. Stillbirth rates and their association with swine leucocyte antigen class II haplotypes in Microminipigs vol.34, pp.11, 2021, https://doi.org/10.5713/ab.20.0763