Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Torilis Fructus Extract on the Relaxation of Corpus Cavernosum

음경해면체 이완작용에 미치는 사상자(蛇床子)의 효과

  • Kim, Ho Hyun (Department of Physiology, College of Korean Medicine, Semyung University) ;
  • Ahn, Sang Hyun (Department of Anatomy, College of Korean Medicine, Semyung University) ;
  • Park, Sun Young (Department of Physiology, College of Korean Medicine, Semyung University)
  • 김호현 (세명대학교 한의과대학 생리학교실) ;
  • 안상현 (세명대학교 한의과대학 해부학교실) ;
  • 박선영 (세명대학교 한의과대학 생리학교실)
  • Received : 2017.12.21
  • Accepted : 2018.02.27
  • Published : 2018.02.25
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Abstract

In order to define the effect of Torilis Fructus(TF) extract which has been used for the treatment of erectile dysfunction, experiments were carried out by organ bath study, histochemical and immunohistochemical methods. First, in the organ bath study, when TF extract was administered to the maxillary contracted corpus cavernosum by PE ($10^{-6}M$), there was a significant relaxation effect on corpus cavernosum at concentration of 1, $3mg/m{\ell}$. Compared with the absence of $\text\tiny{L}$-NNA pretreatmen, pretreatment of $\text\tiny{L}$-NNA was inhibited the relaxation effect of penile corpus cavernosum. In the immunohistochemical study, the eNOS positive reaction was significantly increased, and the PDE5 positive reaction was significantly decreased due to the administration of TF extract. Therefore, it show that the TF enhances the production of eNOS and NO, inhibits PDE5 which blocks the action of increased cGMP, relaxes the corpus cavernosum. So TF relaxes the corpus cavernosum and it can be used as a safer erectile dysfunction treatment.

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References

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