Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Antidepressant Effects of Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai via Inhibition of 5-HT6 Receptor-mediated cyclic AMP Activity

  • Oh, Kyo-nyeo (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Oh, Dool-Ri (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Jung, Myung-A (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Kim, Yujin (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Choi, Eun Jin (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Hong, Ji Ae (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Kim, Jaeyong (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research) ;
  • Choi, Chul-yung (Jeonnam Bioindustry Foundation, Jeonnam Institute of Natural Resources Research)
  • Received : 2018.04.12
  • Accepted : 2018.08.28
  • Published : 2018.08.25
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Abstract

A This study evaluated the antidepressant effects of the herbal mixture CPAE(Cynanchum wilfordii Hemsley, Phlomis umbrosa Turcz, and Angelica gigas Nakai) using several tests, including a test for serotonin 6($5-HT_6$) receptor activity, the forced swimming test(FST), and tests for corticosterone(CORT) and monoamine levels. CPAE showed antagonistic effects on the $5-HT_6$ receptor in a stable $5-HT_6$ receptor-expressing cell line. We subsequently confirmed the antidepressant effects of CPAE in chronic stress model in mice and explored the underlying mechanisms of its action. Specifically, we observed that CPAE treatment significantly reduced immobility time in the FST and effectively restored abnormal levels of CORT in plasma and of monoamines(serotonin, dopamine, and norepinephrine) in hippocampus and prefrontal cortex. These results suggest that CPAE has significant antidepressant effects.

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References

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