Asian-Australasian Journal of Animal Sciences

  • 제32권2호
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  • Pages.217-223
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  • 2019
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Effects of feed intake restriction during late pregnancy on the function, anti-oxidation capability and acute phase protein synthesis of ovine liver

  • Yang, Huan (College of Animal Science, Inner Mongolia Agricultural University) ;
  • Wang, Ying (College of Animal Science, Inner Mongolia Agricultural University) ;
  • Ma, Chi (College of Animal Science, Inner Mongolia Agricultural University) ;
  • Sun, Chuan (College of Animal Science, Inner Mongolia Agricultural University) ;
  • Liu, Yingchun (College of Life Science, Inner Mongolia Agricultural University) ;
  • Wu, Kaifeng (College of Life Science, Inner Mongolia Agricultural University) ;
  • Li, Ming (College of Animal Science, Inner Mongolia Agricultural University) ;
  • Borjigin, Gerelt (College of Food Science and Engineering, Inner Mongolia Agricultural University) ;
  • Gao, Feng (College of Animal Science, Inner Mongolia Agricultural University)
  • 투고 : 2018.04.26
  • 심사 : 2018.07.12
  • 발행 : 2019.02.01
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초록

Objective: An experiment was conducted to investigate the effects of feed intake restriction during late pregnancy on the function, anti-oxidation capability and acute phase protein synthesis of ovine liver. Methods: Eighteen time-mated ewes with singleton fetuses were allocated to three groups: restricted group 1 (RG1, 0.18 MJ ME/kg $W^{0.75}$ d, n = 6), restricted group 2 (RG2, 0.33 MJ ME/kg $W^{0.75}$ d), n = 6) and a control group (CG, ad libitum, 0.67 MJ ME/kg $W^{0.75}$ d, n = 6). The feed restriction period was from 90 days to 140 days of pregnancy. Results: The ewe's body weight, liver weights, water, and protein content of liver in the restricted groups were reduced compared with the CG group (p<0.05), but the liver fat contents in the RG1 group were higher than those of the CG group (p<0.05). The increased hepatic collagen fibers and reticular fibers were observed in the restricted groups with the reduction of energy intake. The concentrations of nonesterified free fatty acids in the RG1 and RG2 groups were higher than those of the CG group with the reduction of energy intake (p<0.05), but there were decreased concentrations of lipoprotein lipase and hepatic lipase in both restricted groups compared with the CG group (p<0.05). In addition, the increased concentrations of ${\beta}$-hydroxybutyric acid, triglycerides, malondialdehyde, total antioxidant capacity and activities of superoxide dismutase activity and catalase were found in the RG1 group, and the concentrations of cholinesterase in the RG1 group were reduced compared with the CG group (p<0.05). For the concentrations of acute phase proteins, the C-reactive protein (CRP) in the RG1 group were reduced compared with the CG group, but there were no differences in haptoglobin relative to the controls (p>0.05). Conclusion: The fat accumulation, increased hepatic fibrosis, antioxidant imbalance and modified synthesis of acute phase proteins were induced in ewe's liver by maternal malnutrition during late pregnancy, which were detrimental for liver function to accommodate pregnancy.

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피인용 문헌

  1. Acute‐phase proteins, cortisol and haematological parameters in ewes during the periparturient period vol.55, pp.3, 2020, https://doi.org/10.1111/rda.13628
  2. Advances in managing pregnancy toxaemia in sheep vol.43, pp.2, 2019, https://doi.org/10.1002/inpr.17
  3. Dietary rumen-protected L-arginine or N-carbamylglutamate attenuated fetal hepatic inflammation in undernourished ewes suffering from intrauterine growth restriction vol.7, pp.4, 2019, https://doi.org/10.1016/j.aninu.2021.06.004