DOI QR코드

DOI QR Code

Outcomes of Carotid Endarterectomy according to the Anesthetic Method: General versus Regional Anesthesia

  • Kim, Jong Won (Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine) ;
  • Huh, Up (Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine) ;
  • Song, Seunghwan (Department of Thoracic and Cardiovascular Surgery, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine) ;
  • Sung, Sang Min (Department of Neurology, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine) ;
  • Hong, Jung Min (Department of Anesthesiology and Pain Medicine, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine) ;
  • Cho, Areum (Department of Anesthesiology and Pain Medicine, Pusan National University Hospital, Biomedical Research Institute, Pusan National University School of Medicine)
  • Received : 2019.01.29
  • Accepted : 2019.07.06
  • Published : 2019.12.05

Abstract

Background: The surgical strategies for carotid endarterectomy (CEA) vary in terms of the anesthesia method, neurological monitoring, shunt usage, and closure technique, and no gold-standard procedure has been established yet. We aimed to analyze the feasibility and benefits of CEA under regional anesthesia (RA) and CEA under general anesthesia (GA). Methods: Between June 2012 and December 2017, 65 patients who had undergone CEA were enrolled, and their medical records were prospectively collected and retrospectively reviewed. A total of 35 patients underwent CEA under RA with cervical plexus block, whereas 30 patients underwent CEA under GA. In the RA group, a carotid shunt was selectively used for patients who exhibited negative results on the awake test. In contrast, such a shunt was used for all patients in the GA group. Results: There were no cases of postoperative stroke, cardiovascular events, or mortality. Nerve injuries were noted in 4 patients (3 in the RA group and 1 in the GA group), but they fully recovered prior to discharge. Operative time and clamp time were shorter in the RA group than in the GA group (119.29±27.71 min vs. 161.43±20.79 min, p<0.001; 30.57±6.80 min vs. 51.77±13.38 min, p<0.001, respectively). The hospital stay was shorter in the RA group than in the GA group (14.6±5.05 days vs. 18.97±8.92 days, p=0.022). None of the patients experienced a stroke or restenosis during the 27.23±20.3-month follow-up period. Conclusion: RA with a reliable awake test reduces shunt use and decreases the clamp and operative times of CEA, eventually resulting in a reduced length of hospital stay.

Keywords

References

  1. North American Symptomatic Carotid Endarterectomy Trial Collaborators, Barnett HJ, Taylor DW, et al. Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. N Engl J Med 1991;325:445-53. https://doi.org/10.1056/NEJM199108153250701
  2. North American Symptomatic Carotid Endarterectomy Trial (NASCET) investigators. Clinical alert: benefit of carotid endarterectomy for patients with high-grade stenosis of the internal carotid artery. National Institute of Neurological Disorders and Stroke Stroke and Trauma Division. Stroke 1991;22:816-7. https://doi.org/10.1161/01.str.22.6.816
  3. Bond R, Rerkasem K, Rothwell PM. Routine or selective carotid artery shunting for carotid endarterectomy (and different methods of monitoring in selective shunting). Stroke 2003;34:824-5. https://doi.org/10.1161/01.str.0000059381.17983.77
  4. Rerkasem K, Rothwell PM. Local versus general anaesthesia for carotid endarterectomy. Cochrane Database Syst Rev 2008;(4):CD000126.
  5. Schechter MA, Shortell CK, Scarborough JE. Regional versus general anesthesia for carotid endarterectomy: the American College of Surgeons National Surgical Quality Improvement Program perspective. Surgery 2012;152:309-14. https://doi.org/10.1016/j.surg.2012.05.008
  6. Aburahma AF, Mousa AY, Stone PA. Shunting during carotid endarterectomy. J Vasc Surg 2011;54:1502-10. https://doi.org/10.1016/j.jvs.2011.06.020
  7. Kavrut Ozturk N, Kavakli AS, Sagdic K, Inanoglu K, Umot Ayoglu R. A randomized controlled trial examining the effect of the addition of the mandibular block to cervical plexus block for carotid endarterectomy. J Cardiothorac Vasc Anesth 2018;32:877-82. https://doi.org/10.1053/j.jvca.2017.06.034
  8. Kuzkov VV, Obraztsov MY, Ivashchenko OY, Ivashchenko NY, Gorenkov VM, Kirov MY. Total intravenous versus volatile induction and maintenance of anesthesia in elective carotid endarterectomy: effects on cerebral oxygenation and cognitive functions. J Cardiothorac Vasc Anesth 2018;32:1701-8. https://doi.org/10.1053/j.jvca.2017.12.049
  9. Ladak N, Thompson J. General or local anaesthesia for carotid endarterectomy? Contin Educ Anaesth Crit Care Pain 2012;12:92-6. https://doi.org/10.1093/bjaceaccp/mkr061
  10. Head BP, Patel P. Anesthetics and brain protection. Curr Opin Anaesthesiol 2007;20:395-9. https://doi.org/10.1097/ACO.0b013e3282efa69d
  11. Gomes M, Soares MO, Dumville JC, et al. Cost-effectiveness analysis of general anaesthesia versus local anaesthesia for carotid surgery (GALA Trial). Br J Surg 2010;97:1218-25. https://doi.org/10.1002/bjs.7110
  12. Malik OS, Brovman EY, Urman RD. The use of regional or local anesthesia for carotid endarterectomies may reduce blood loss and pulmonary complications. J Cardiothorac Vasc Anesth 2019;33:935-42. https://doi.org/10.1053/j.jvca.2018.08.195
  13. Aburahma AF, Stone PA, Hass SM, et al. Prospective randomized trial of routine versus selective shunting in carotid endarterectomy based on stump pressure. J Vasc Surg 2010;51:1133-8. https://doi.org/10.1016/j.jvs.2009.12.046
  14. Unic-Stojanovic D, Babic S, Neskovic V. General versus regional anesthesia for carotid endarterectomy. J Cardiothorac Vasc Anesth 2013;27:1379-83. https://doi.org/10.1053/j.jvca.2012.09.021
  15. Cho JW, Jang JS. Near-infrared spectroscopy versus transcranial doppler-based monitoring in carotid endarterectomy. Korean J Thorac Cardiovasc Surg 2017;50:448-52. https://doi.org/10.5090/kjtcs.2017.50.6.448
  16. Chang JW, Kim SW, Lee S, Lee J, Ku MJ. Dual monitoring with stump pressure and electroencephalography during carotid endarterectomy. Korean J Thorac Cardiovasc Surg 2017;50:94-8. https://doi.org/10.5090/kjtcs.2017.50.2.94
  17. Cho JW, Jeon YH, Bae CH. Selective carotid shunting based on intraoperative transcranial doppler imaging during carotid endarterectomy: a retrospective single-center review. Korean J Thorac Cardiovasc Surg 2016;49:22-8. https://doi.org/10.5090/kjtcs.2016.49.1.22
  18. Kim TY, Choi JB, Kim KH, Kim MH, Shin BS, Park HK. Routine shunting is safe and reliable for cerebral perfusion during carotid endarterectomy in symptomatic carotid stenosis. Korean J Thorac Cardiovasc Surg 2012;45:95-100. https://doi.org/10.5090/kjtcs.2012.45.2.95
  19. McCarthy RJ, Walker R, McAteer P, Budd JS, Horrocks M. Patient and hospital benefits of local anaesthesia for carotid endarterectomy. Eur J Vasc Endovasc Surg 2001;22:13-8. https://doi.org/10.1053/ejvs.2001.1381
  20. Kalko Y, Kafali E, Aydin U, et al. Surgery of the carotid artery: local anaesthesia versus general anaesthesia. Acta Chir Belg 2007;107:53-7. https://doi.org/10.1080/00015458.2007.11680011
  21. Demirel S, Attigah N, Bruijnen H, et al. Changes in baroreceptor sensitivity after eversion carotid endarterectomy. J Vasc Surg 2012;55:1322-8. https://doi.org/10.1016/j.jvs.2011.11.134
  22. Stoneham MD, Stamou D, Mason J. Regional anaesthesia for carotid endarterectomy. Br J Anaesth 2015;114:372-83. https://doi.org/10.1093/bja/aeu304
  23. Bekker AY, Basile J, Gold M, et al. Dexmedetomidine for awake carotid endarterectomy: efficacy, hemodynamic profile, and side effects. J Neurosurg Anesthesiol 2004;16:126-35. https://doi.org/10.1097/00008506-200404000-00004