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Successful Transition from Pediatric to Adult Care in Inflammatory Bowel Disease: What is the Key?

  • Kim, Jeongseok (Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ye, Byong Duk (Inflammatory Bowel Disease Center, Asan Medical Center, University of Ulsan College of Medicine)
  • Received : 2018.11.23
  • Accepted : 2018.11.28
  • Published : 2019.01.15

Abstract

The incidence of pediatric-onset inflammatory bowel disease (IBD) is on the rise, accounting for up to 25% of IBD cases. Pediatric IBD often has extensive bowel involvement with aggressive and rapidly progressing behavior compared to adult IBD. Because IBD has a high morbidity rate and can have a lifelong impact, successful transition from pediatric to adult care is important to maintain the continuity of care. Furthermore, successful transition facilitates appropriate development and psychosocial well-being among patients, as well as comprehensive and harmonious healthcare delivery amongst stakeholders. However, there are various obstacles related to patients, family, providers, and organizations that interfere with successful transition. Successful transition requires a flexible and tailored plan that is made according to the patient's developmental abilities and situation. This plan should be established through periodic interviews with the patient and family and through close collaboration with other care providers. Through a stepwise approach to the transition process, patients' knowledge and self-management skills can be improved. After preparation for the transition is completed and the obstacles are overcome, patients can be gradually moved to adult care. Finally, successful transition can increase patients' adherence to therapy, maintain the appropriate health status, improve patients' self-management, and promote self-reliance among patients.

Keywords

References

  1. Benchimol EI, Fortinsky KJ, Gozdyra P, Van den Heuvel M, Van Limbergen J, Griffiths AM. Epidemiology of pediatric inflammatory bowel disease: a systematic review of international trends. Inflamm Bowel Dis 2011;17:423-39. https://doi.org/10.1002/ibd.21349
  2. Benchimol EI, Mack DR, Nguyen GC, Snapper SB, Li W, Mojaverian N, et al. Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease. Gastroenterology 2014;147:803-13.e7; quiz e14-5. https://doi.org/10.1053/j.gastro.2014.06.023
  3. Afzali A, Katz S. Inflammatory bowel disease in the baby to baby boomer: pediatric and elderly onset of IBD. Curr Treat Options Gastroenterol 2018;16:289-305. https://doi.org/10.1007/s11938-018-0188-9
  4. Sykora J, Pomahacova R, Kreslova M, Cvalinova D, Stych P, Schwarz J. Current global trends in the incidence of pediatric-onset inflammatory bowel disease. World J Gastroenterol 2018;24:2741-63. https://doi.org/10.3748/wjg.v24.i25.2741
  5. Paul T, Birnbaum A, Pal DK, Pittman N, Ceballos C, LeLeiko NS, et al. Distinct phenotype of early childhood inflammatory bowel disease. J Clin Gastroenterol 2006;40:583-6. https://doi.org/10.1097/00004836-200608000-00004
  6. Van Limbergen J, Russell RK, Drummond HE, Aldhous MC, Round NK, Nimmo ER, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 2008;135:1114-22. https://doi.org/10.1053/j.gastro.2008.06.081
  7. Goodhand J, Hedin CR, Croft NM, Lindsay JO. Adolescents with IBD: the importance of structured transition care. J Crohns Colitis 2011;5:509-19. https://doi.org/10.1016/j.crohns.2011.03.015
  8. Hait EJ, Barendse RM, Arnold JH, Valim C, Sands BE, Korzenik JR, et al. Transition of adolescents with inflammatory bowel disease from pediatric to adult care: a survey of adult gastroenterologists. J Pediatr Gastroenterol Nutr 2009;48:61-5. https://doi.org/10.1097/MPG.0b013e31816d71d8
  9. Sebastian S, Jenkins H, McCartney S, Ahmad T, Arnott I, Croft N, et al. The requirements and barriers to successful transition of adolescents with inflammatory bowel disease: differing perceptions from a survey of adult and paediatric gastroenterologists. J Crohns Colitis 2012;6:830-44. https://doi.org/10.1016/j.crohns.2012.01.010
  10. American Academy of Pediatrics; American Academy of Family Physicians; American College of Physicians-American Society of Internal Medicine. A consensus statement on health care transitions for young adults with special health care needs. Pediatrics 2002;110:1304-6.
  11. American Academy of Pediatrics; American Academy of Family Physicians; American College of Physicians; Transitions Clinical Report Authoring Group, Cooley WC, Sagerman PJ. Supporting the health care transition from adolescence to adulthood in the medical home. Pediatrics 2011;128:182-200. https://doi.org/10.1542/peds.2011-0969
  12. Gray WN, Maddux MH. Current transition practices in pediatric IBD: findings from a National Survey of Pediatric Providers. Inflamm Bowel Dis 2016;22:372-9. https://doi.org/10.1097/MIB.0000000000000642
  13. Gray WN, Holbrook E, Morgan PJ, Saeed SA, Denson LA, Hommel KA. Transition readiness skills acquisition in adolescents and young adults with inflammatory bowel disease: findings from integrating assessment into clinical practice. Inflamm Bowel Dis 2015;21:1125-31. https://doi.org/10.1097/MIB.0000000000000352
  14. Zeisler B, Hyams JS. Transition of management in adolescents with IBD. Nat Rev Gastroenterol Hepatol 2014;11:109-15. https://doi.org/10.1038/nrgastro.2013.254
  15. Clarke T, Lusher J. Transitioning patients with inflammatory bowel disease (IBD) from adolescent to adult services: a systematic review. Frontline Gastroenterol 2016;7:264-70. https://doi.org/10.1136/flgastro-2015-100575
  16. Afzali A, Wahbeh G. Transition of pediatric to adult care in inflammatory bowel disease: is it as easy as 1, 2, 3? World J Gastroenterol 2017;23:3624-31. https://doi.org/10.3748/wjg.v23.i20.3624
  17. van Rheenen PF, Aloi M, Biron IA, Carlsen K, Cooney R, Cucchiara S, et al. European Crohn's and Colitis Organisation topical review on transitional care in inflammatory bowel disease. J Crohns Colitis 2017;11:1032-8. https://doi.org/10.1093/ecco-jcc/jjx010
  18. Philpott JR, Kurowski JA. Challenges in transitional care in inflammatory bowel disease: a review of the current literature in transition readiness and outcomes. Inflamm Bowel Dis 2019;25:45-55. https://doi.org/10.1093/ibd/izy207
  19. Duricova D, Fumery M, Annese V, Lakatos PL, Peyrin-Biroulet L, Gower-Rousseau C. The natural history of Crohn's disease in children: a review of populationbased studies. Eur J Gastroenterol Hepatol 2017;29:125-34. https://doi.org/10.1097/MEG.0000000000000761
  20. Heyman MB, Kirschner BS, Gold BD, Ferry G, Baldassano R, Cohen SA, et al. Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry. J Pediatr 2005;146:35-40. https://doi.org/10.1016/j.jpeds.2004.08.043
  21. Vernier-Massouille G, Balde M, Salleron J, Turck D, Dupas JL, Mouterde O, et al. Natural history of pediatric Crohn's disease: a population-based cohort study. Gastroenterology 2008;135:1106-13. https://doi.org/10.1053/j.gastro.2008.06.079
  22. Kappelman MD, Rifas-Shiman SL, Kleinman K, Ollendorf D, Bousvaros A, Grand RJ, et al. The prevalence and geographic distribution of Crohn's disease and ulcerative colitis in the United States. Clin Gastroenterol Hepatol 2007;5:1424-9. https://doi.org/10.1016/j.cgh.2007.07.012
  23. Ishige T, Tomomasa T, Takebayashi T, Asakura K, Watanabe M, Suzuki T, et al. Inflammatory bowel disease in children: epidemiological analysis of the nationwide IBD registry in Japan. J Gastroenterol 2010;45:911-7. https://doi.org/10.1007/s00535-010-0223-7
  24. Cosnes J, Gower-Rousseau C, Seksik P, Cortot A. Epidemiology and natural history of inflammatory bowel diseases. Gastroenterology 2011;140:1785-94. https://doi.org/10.1053/j.gastro.2011.01.055
  25. Bernstein CN, Wajda A, Svenson LW, MacKenzie A, Koehoorn M, Jackson M, et al. The epidemiology of inflammatory bowel disease in Canada: a populationbased study. Am J Gastroenterol 2006;101:1559-68. https://doi.org/10.1111/j.1572-0241.2006.00603.x
  26. Oh SH, Kim KM. Current issues of pediatric inflammatory bowel disease in Korea. Korean J Pediatr 2014;57:465-71. https://doi.org/10.3345/kjp.2014.57.11.465
  27. Adamiak T, Walkiewicz-Jedrzejczak D, Fish D, Brown C, Tung J, Khan K, et al. Incidence, clinical characteristics, and natural history of pediatric IBD in Wisconsin: a population-based epidemiological study. Inflamm Bowel Dis 2013;19:1218-23. https://doi.org/10.1097/MIB.0b013e318280b13e
  28. Charpentier C, Salleron J, Savoye G, Fumery M, Merle V, Laberenne JE, et al. Natural history of elderly-onset inflammatory bowel disease: a population-based cohort study. Gut 2014;63:423-32. https://doi.org/10.1136/gutjnl-2012-303864
  29. de Bie CI, Paerregaard A, Kolacek S, Ruemmele FM, Koletzko S, Fell JM, et al. Disease phenotype at diagnosis in pediatric Crohn's disease: 5-year analyses of the EUROKIDS Registry. Inflamm Bowel Dis 2013;19:378-85. https://doi.org/10.1002/ibd.23008
  30. Levine A, de Bie CI, Turner D, Cucchiara S, Sladek M, Murphy MS, et al. Atypical disease phenotypes in pediatric ulcerative colitis: 5-year analyses of the EUROKIDS Registry. Inflamm Bowel Dis 2013;19:370-7. https://doi.org/10.1002/ibd.23013
  31. Hong SJ, Cho SM, Choe BH, Jang HJ, Choi KH, Kang B, et al. Characteristics and incidence trends for pediatric inflammatory bowel disease in Daegu-Kyungpook province in Korea: a multi-center study. J Korean Med Sci 2018;33:e132. https://doi.org/10.3346/jkms.2018.33.e132
  32. Kim HJ, Oh SH, Kim DY, Lee HS, Park SH, Yang SK, et al. Clinical characteristics and long-term outcomes of paediatric Crohn's disease: a single-centre experience. J Crohns Colitis 2017;11:157-64. https://doi.org/10.1093/ecco-jcc/jjw146
  33. Wang XQ, Xiao Y, Xu X, Yu Y, Shan CY, Guo Y, et al. Study of disease phenotype and its association with prognosis of paediatric inflammatory bowel disease in China. BMC Pediatr 2018;18:229. https://doi.org/10.1186/s12887-018-1212-x
  34. Pigneur B, Seksik P, Viola S, Viala J, Beaugerie L, Girardet JP, et al. Natural history of Crohn's disease: comparison between childhood- and adult-onset disease. Inflamm Bowel Dis 2010;16:953-61. https://doi.org/10.1002/ibd.21152
  35. Nasiri S, Kuenzig ME, Benchimol EI. Long-term outcomes of pediatric inflammatory bowel disease. Semin Pediatr Surg 2017;26:398-404. https://doi.org/10.1053/j.sempedsurg.2017.10.010
  36. Fumery M, Duricova D, Gower-Rousseau C, Annese V, Peyrin-Biroulet L, Lakatos PL. Review article: the natural history of paediatric-onset ulcerative colitis in population-based studies. Aliment Pharmacol Ther 2016;43:346-55. https://doi.org/10.1111/apt.13478
  37. Griffiths AM. Specificities of inflammatory bowel disease in childhood. Best Pract Res Clin Gastroenterol 2004;18:509-23. https://doi.org/10.1016/j.bpg.2004.01.002
  38. Vaisman N, Dotan I, Halack A, Niv E. Malabsorption is a major contributor to underweight in Crohn's disease patients in remission. Nutrition 2006;22:855-9. https://doi.org/10.1016/j.nut.2006.05.013
  39. Gasparetto M, Guariso G. Crohn's disease and growth deficiency in children and adolescents. World J Gastroenterol 2014;20:13219-33. https://doi.org/10.3748/wjg.v20.i37.13219
  40. Rosen MJ, Dhawan A, Saeed SA. Inflammatory bowel disease in children and adolescents. JAMA Pediatr 2015;169:1053-60. https://doi.org/10.1001/jamapediatrics.2015.1982
  41. Heuschkel R, Salvestrini C, Beattie RM, Hildebrand H, Walters T, Griffiths A. Guidelines for the management of growth failure in childhood inflammatory bowel disease. Inflamm Bowel Dis 2008;14:839-49. https://doi.org/10.1002/ibd.20378
  42. Ley D, Duhamel A, Behal H, Vasseur F, Sarter H, Michaud L, et al. Growth pattern in paediatric Crohn disease is related to inflammatory status. J Pediatr Gastroenterol Nutr 2016;63:637-43. https://doi.org/10.1097/MPG.0000000000001177
  43. Lee JJ, Escher JC, Shuman MJ, Forbes PW, Delemarre LC, Harr BW, et al. Final adult height of children with inflammatory bowel disease is predicted by parental height and patient minimum height Z-score. Inflamm Bowel Dis 2010;16:1669-77. https://doi.org/10.1002/ibd.21214
  44. Davies JH, Evans BA, Gregory JW. Bone mass acquisition in healthy children. Arch Dis Child 2005;90:373-8. https://doi.org/10.1136/adc.2004.053553
  45. Jakobsen C, Paerregaard A, Munkholm P, Faerk J, Lange A, Andersen J, et al. Pediatric inflammatory bowel disease: increasing incidence, decreasing surgery rate, and compromised nutritional status: a prospective population-based cohort study 2007-2009. Inflamm Bowel Dis 2011;17:2541-50. https://doi.org/10.1002/ibd.21654
  46. Ballinger AB, Savage MO, Sanderson IR. Delayed puberty associated with inflammatory bowel disease. Pediatr Res 2003;53:205-10. https://doi.org/10.1203/00006450-200302000-00002
  47. Perminow G, Brackmann S, Lyckander LG, Franke A, Borthne A, Rydning A, et al. A characterization in childhood inflammatory bowel disease, a new populationbased inception cohort from South-Eastern Norway, 2005-07, showing increased incidence in Crohn's disease. Scand J Gastroenterol 2009;44:446-56. https://doi.org/10.1080/00365520802647434
  48. Duigenan S, Gee MS. Imaging of pediatric patients with inflammatory bowel disease. AJR Am J Roentgenol 2012;199:907-15. https://doi.org/10.2214/AJR.11.7966
  49. Towbin AJ, Sullivan J, Denson LA, Wallihan DB, Podberesky DJ. CT and MR enterography in children and adolescents with inflammatory bowel disease. Radiographics 2013;33:1843-60. https://doi.org/10.1148/rg.337105140
  50. Pall H, Zacur GM, Kramer RE, Lirio RA, Manfredi M, Shah M, et al. Bowel preparation for pediatric colonoscopy: report of the NASPGHAN endoscopy and procedures committee. J Pediatr Gastroenterol Nutr 2014;59:409-16. https://doi.org/10.1097/MPG.0000000000000447
  51. Ruemmele FM, Veres G, Kolho KL, Griffiths A, Levine A, Escher JC, et al. Consensus guidelines of ECCO/ ESPGHAN on the medical management of pediatric Crohn's disease. J Crohns Colitis 2014;8:1179-207. https://doi.org/10.1016/j.crohns.2014.04.005
  52. Lakatos PL, Golovics PA, David G, Pandur T, Erdelyi Z, Horvath A, et al. Has there been a change in the natural history of Crohn's disease? Surgical rates and medical management in a population-based inception cohort from Western Hungary between 1977-2009. Am J Gastroenterol 2012;107:579-88. https://doi.org/10.1038/ajg.2011.448
  53. Vilar P, de Carpi JM, Acuna CE, Masiques MA. Infliximab in paediatric inflammatory bowel disease. J Crohns Colitis 2007;1:2-9. https://doi.org/10.1016/j.crohns.2007.07.001
  54. Ruemmele FM, Turner D. Differences in the management of pediatric and adult onset ulcerative colitis--lessons from the joint ECCO and ESPGHAN consensus guidelines for the management of pediatric ulcerative colitis. J Crohns Colitis 2014;8:1-4. https://doi.org/10.1016/j.crohns.2013.10.006
  55. Jakobsen C, Bartek J Jr, Wewer V, Vind I, Munkholm P, Groen R, et al. Differences in phenotype and disease course in adult and paediatric inflammatory bowel disease--a population-based study. Aliment Pharmacol Ther 2011;34:1217-24. https://doi.org/10.1111/j.1365-2036.2011.04857.x
  56. Frolkis AD, Dykeman J, Negron ME, Debruyn J, Jette N, Fiest KM, et al. Risk of surgery for inflammatory bowel diseases has decreased over time: a systematic review and meta-analysis of population-based studies. Gastroenterology 2013;145:996-1006. https://doi.org/10.1053/j.gastro.2013.07.041
  57. Malik S, Ahmed SF, Wilson ML, Shah N, Loganathan S, Naik S, et al. The effects of anti-$TNF-{\alpha}$ treatment with adalimumab on growth in children with Crohn's disease (CD). J Crohns Colitis 2012;6:337-44. https://doi.org/10.1016/j.crohns.2011.09.004
  58. Borrelli O, Bascietto C, Viola F, Bueno de Mesquita M, Barbato M, Mancini V, et al. Infliximab heals intestinal inflammatory lesions and restores growth in children with Crohn's disease. Dig Liver Dis 2004;36:342-7. https://doi.org/10.1016/j.dld.2003.12.014
  59. Walters TD, Gilman AR, Griffiths AM. Linear growth improves during infliximab therapy in children with chronically active severe Crohn's disease. Inflamm Bowel Dis 2007;13:424-30. https://doi.org/10.1002/ibd.20069
  60. Malik S, Wong SC, Bishop J, Hassan K, McGrogan P, Ahmed SF, et al. Improvement in growth of children with Crohn disease following anti-$TNF-{\alpha}$ therapy can be independent of pubertal progress and glucocorticoid reduction. J Pediatr Gastroenterol Nutr 2011;52:31-7. https://doi.org/10.1097/MPG.0b013e3181edd797
  61. Blum RW, Garell D, Hodgman CH, Jorissen TW, Okinow NA, Orr DP, et al. Transition from child-centered to adult health-care systems for adolescents with chronic conditions. A position paper of the Society for Adolescent Medicine. J Adolesc Health 1993;14:570-6. https://doi.org/10.1016/1054-139X(93)90143-D
  62. Gumidyala AP, Greenley RN, Plevinsky JM, Poulopoulos N, Cabrera J, Lerner D, et al. Moving on: transition readiness in adolescents and young adults with IBD. Inflamm Bowel Dis 2018;24:482-9. https://doi.org/10.1093/ibd/izx051
  63. Hait E, Arnold JH, Fishman LN. Educate, communicate, anticipate-practical recommendations for transitioning adolescents with IBD to adult health care. Inflamm Bowel Dis 2006;12:70-3. https://doi.org/10.1097/01.MIB.0000194182.85047.6a
  64. Baldassano R, Ferry G, Griffiths A, Mack D, Markowitz J, Winter H. Transition of the patient with inflammatory bowel disease from pediatric to adult care: recommendations of the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. J Pediatr Gastroenterol Nutr 2002;34:245-8. https://doi.org/10.1097/00005176-200203000-00001
  65. de Silva PS, Fishman LN. Transition of the patient with IBD from pediatric to adult care-an assessment of current evidence. Inflamm Bowel Dis 2014;20:1458-64. https://doi.org/10.1097/MIB.0000000000000045
  66. Campbell F, Biggs K, Aldiss SK, O'Neill PM, Clowes M, McDonagh J, et al. Transition of care for adolescents from paediatric services to adult health services. Cochrane Database Syst Rev 2016;4:CD009794.
  67. Sawyer SM, Afifi RA, Bearinger LH, Blakemore SJ, Dick B, Ezeh AC, et al. Adolescence: a foundation for future health. Lancet 2012;379:1630-40. https://doi.org/10.1016/S0140-6736(12)60072-5
  68. Gray WN, Schaefer MR, Resmini-Rawlinson A, Wagoner ST. Barriers to transition from pediatric to adult care: a systematic review. J Pediatr Psychol 2018;43:488-502. https://doi.org/10.1093/jpepsy/jsx142
  69. Keefer L, Kiebles JL, Taft TH. The role of self-efficacy in inflammatory bowel disease management: preliminary validation of a disease-specific measure. Inflamm Bowel Dis 2011;17:614-20. https://doi.org/10.1002/ibd.21314
  70. Hommel KA, Greenley RN, Maddux MH, Gray WN, Mackner LM. Self-management in pediatric inflammatory bowel disease: a clinical report of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 2013;57:250-7. https://doi.org/10.1097/MPG.0b013e3182999b21
  71. Kahn SA. The transition from pediatric to adult inflammatory bowel disease care. Gastroenterol Hepatol (N Y) 2016;12:403-6.
  72. Sawicki GS, Lukens-Bull K, Yin X, Demars N, Huang IC, Livingood W, et al. Measuring the transition readiness of youth with special healthcare needs: validation of the TRAQ--Transition Readiness Assessment Questionnaire. J Pediatr Psychol 2011;36:160-71. https://doi.org/10.1093/jpepsy/jsp128
  73. Wood DL, Sawicki GS, Miller MD, Smotherman C, Lukens-Bull K, Livingood WC, et al. The Transition Readiness Assessment Questionnaire (TRAQ): its factor structure, reliability, and validity. Acad Pediatr 2014;14:415-22. https://doi.org/10.1016/j.acap.2014.03.008
  74. Schwartz LA, Tuchman LK, Hobbie WL, Ginsberg JP. A social-ecological model of readiness for transition to adult-oriented care for adolescents and young adults with chronic health conditions. Child Care Health Dev 2011;37:883-95. https://doi.org/10.1111/j.1365-2214.2011.01282.x
  75. Gilleland J, Amaral S, Mee L, Blount R. Getting ready to leave: transition readiness in adolescent kidney transplant recipients. J Pediatr Psychol 2012;37:85-96. https://doi.org/10.1093/jpepsy/jsr049
  76. Ferris ME, Harward DH, Bickford K, Layton JB, Ferris MT, Hogan SL, et al. A clinical tool to measure the components of health-care transition from pediatric care to adult care: the UNC TR(x)ANSITION scale. Ren Fail 2012;34:744-53. https://doi.org/10.3109/0886022X.2012.678171
  77. Benchimol EI, Walters TD, Kaufman M, Frost K, Fiedler K, Chinea Z, et al. Assessment of knowledge in adolescents with inflammatory bowel disease using a novel transition tool. Inflamm Bowel Dis 2011;17:1131-7. https://doi.org/10.1002/ibd.21464
  78. Fishman LN, Houtman D, van Groningen J, Arnold J, Ziniel S. Medication knowledge: an initial step in selfmanagement for youth with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2011;53:641-5. https://doi.org/10.1097/mpg.0b013e3182285316
  79. Izaguirre MR, Keefer L. Development of a self-efficacy scale for adolescents and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2014;59:29-32. https://doi.org/10.1097/MPG.0000000000000357
  80. Yerushalmy-Feler A, Ron Y, Barnea E, Nachum A, Matalon S, Dali-Levy M, et al. Adolescent transition clinic in inflammatory bowel disease: quantitative assessment of self-efficacy skills. Eur J Gastroenterol Hepatol 2017;29:831-7. https://doi.org/10.1097/MEG.0000000000000864
  81. Izaguirre MR, Taft T, Keefer L. Validation of a self-efficacy scale for adolescents and young adults with inflammatory bowel disease. J Pediatr Gastroenterol Nutr 2017;65:546-50. https://doi.org/10.1097/MPG.0000000000001552
  82. Brooks AJ, Smith PJ, Lindsay JO. Monitoring adolescents and young people with inflammatory bowel disease during transition to adult healthcare. Frontline Gastroenterol 2018;9:37-44. https://doi.org/10.1136/flgastro-2016-100747
  83. Greenley RN, Stephens M, Doughty A, Raboin T, Kugathasan S. Barriers to adherence among adolescents with inflammatory bowel disease. Inflamm Bowel Dis 2010;16:36-41. https://doi.org/10.1002/ibd.20988
  84. Hommel KA, Davis CM, Baldassano RN. Objective versus subjective assessment of oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2009;15:589-93. https://doi.org/10.1002/ibd.20798
  85. Hommel KA, Davis CM, Baldassano RN. Medication adherence and quality of life in pediatric inflammatory bowel disease. J Pediatr Psychol 2008;33:867-74. https://doi.org/10.1093/jpepsy/jsn022
  86. Mackner LM, Crandall WV. Oral medication adherence in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2005;11:1006-12. https://doi.org/10.1097/01.MIB.0000186409.15392.54
  87. Oliva-Hemker MM, Abadom V, Cuffari C, Thompson RE. Nonadherence with thiopurine immunomodulator and mesalamine medications in children with Crohn disease. J Pediatr Gastroenterol Nutr 2007;44:180-4. https://doi.org/10.1097/MPG.0b013e31802b320e
  88. Paine CW, Stollon NB, Lucas MS, Brumley LD, Poole ES, Peyton T, et al. Barriers and facilitators to successful transition from pediatric to adult inflammatory bowel disease care from the perspectives of providers. Inflamm Bowel Dis 2014;20:2083-91. https://doi.org/10.1097/MIB.0000000000000136
  89. Bennett AL, Moore D, Bampton PA, Bryant RV, Andrews JM. Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease. World J Gastroenterol 2016;22:2611-20. https://doi.org/10.3748/wjg.v22.i8.2611
  90. Jeganathan J, Lee CH, Rahme A, Tiao DK, Weston C, Dutt S, et al. Pediatric-to-adult transition and medication adherence in patients with inflammatory bowel disease. Inflamm Bowel Dis 2017;23:1065-70. https://doi.org/10.1097/MIB.0000000000001114
  91. Dabadie A, Troadec F, Heresbach D, Siproudhis L, Pagenault M, Bretagne JF. Transition of patients with inflammatory bowel disease from pediatric to adult care. Gastroenterol Clin Biol 2008;32:451-9. https://doi.org/10.1016/j.gcb.2008.01.044
  92. Fu N, Jacobson K, Round A, Evans K, Qian H, Bressler B. Transition clinic attendance is associated with improved beliefs and attitudes toward medicine in patients with inflammatory bowel disease. World J Gastroenterol 2017;23:5405-11. https://doi.org/10.3748/wjg.v23.i29.5405
  93. Cole R, Ashok D, Razack A, Azaz A, Sebastian S. Evaluation of outcomes in adolescent inflammatory bowel disease patients following transfer from pediatric to adult health care services: case for transition. J Adolesc Health 2015;57:212-7. https://doi.org/10.1016/j.jadohealth.2015.04.012

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