Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Anti-oxidative and Whitening Efects of 4'-O-methylalpinumisoflavone Isolated from Fruit of Maclura Tricuspidata Carrière

꾸지뽕나무 열매에서 추출한 4'-O-methylalpinumisoflavone의 항산화 및 미백 효과

  • Lyu, Ji Hyo (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Noh, Joon Yong (Division of Pharmacology, School of Korean Medicine, Pusan National University) ;
  • Kim, Sura (Bio R&D Center, Sewonbiotech) ;
  • Lee, Guem San (Department of Herbology, College of Korean Medicine, Wonkwang University) ;
  • Lee, Dongho (Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University) ;
  • Kim, Koanhoi (Department of Pharmacology, School of Medicine, Pusan National University) ;
  • Kim, Hyungwoo (Division of Pharmacology, School of Korean Medicine, Pusan National University)
  • 류지효 (부산대학교 한의학전문대학원 약물의학부) ;
  • 노준용 (부산대학교 한의학전문대학원 약물의학부) ;
  • 김수라 ((주)세원생명공학 바이오연구개발센터) ;
  • 이금산 (원광대학교 한의과대학 본초학교실) ;
  • 이동호 (고려대학교 생명과학대학 생명공학부) ;
  • 김관회 (부산대학교 의과대학 약리학교실) ;
  • 김형우 (부산대학교 한의학전문대학원 약물의학부)
  • Received : 2019.10.07
  • Accepted : 2019.12.17
  • Published : 2019.12.25
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Abstract

The anti-inflammatory effects of 4'-O-methylalpinumisoflavone (OMAI) has been reported in recent years. To develop effective and safe skin whitening agents, we investigated the anti-oxidative and melanogenic effects of OMAI isolated from fruit of Maclura tricuspidata Carrière (Cudrania tricuspidata) in macrophage and melanoma cell lines. In our results, OMAI showed effective superoxide scavenging activity and suppressed production of lipopolysaccharide (LPS)-induced intracellular reactive oxygen species (ROS) in RAW264.7 cells. In addition, α-melanocyte stimulation hormone (MSH)-induced production of melanin was also reduced by OMAI in B16F10 cells. Finally, OMAI significantly inhibited tyrosinase activity in B16F10 cells. These results suggest that OMAI suppressed melanin production via scavenging reactive oxygen species and inhibition of tyrosinase activity.

Keywords

References

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