Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지
DOI QR코드

DOI QR Code

Effects of Bombycis Corpus on Male Osteoporosis

백강잠(白殭蠶)이 남성 골다공증에 미치는 영향

  • Kim, Ho Hyun (Department of Physiology, College of Korean Medicine, Semyung University) ;
  • Ahn, Sang Hyun (Department of Anatomy, College of Korean Medicine, Semyung University) ;
  • Park, Sun Young (Department of Physiology, College of Korean Medicine, Semyung University)
  • 김호현 (세명대학교 한의과대학 생리학교실) ;
  • 안상현 (세명대학교 한의과대학 해부학교실) ;
  • 박선영 (세명대학교 한의과대학 생리학교실)
  • Received : 2018.12.26
  • Accepted : 2019.02.20
  • Published : 2019.02.25
Download PDF
⟨ Previous Next ⟩

Abstract

To investigate the effect of Bombycis Corpus on male osteoporosis, we performed Dual Energy X-Ray Absorptiometry(DEXA) and histochemical methods. The animals were used ICR-based male mice of 8 weeks and 50 weeks, respectively. ICR male mice at 8 weeks were used in the control group, and ICR male mice at 50 weeks were used in aging group and Bombycis Corpus group(BC group). In the aging group, 0.5 ml of distilled water was administered once a day for 6 months. In BC group, Bombycis Corpus(0.78g/kg) was dissolved in distilled water for 6 months once a day. As a result, Bombycis Corpus decreased bone loss, increased bone density by reducing the loss of bone matrix in the femur due to aging, and increased osteoblast - induced osteopontin(OPN) and osteocalcin(OPC) positivite reaction. In addition, administration of Bombycis Corpus decreased Reaction of activation of nuclear factor kappa B ligand(RANKL) positive reaction, increased osteoprotegerin(OPG) positive reaction, and decreased matrix metalloproteinase-3(MMP-3) and 8-hydroxy-2'-deoxyguanosine(8-OHdG) positivite reaction. Taken together, Bombycis Corpus increases the activity of osteoblasts, inhibits osteoclast function, promotes osteoblast function, inhibits bone tissue degradation, and inhibits bone loss due to oxidative stress. It was observed that Bombycis Corpus reduced bone loss and increased bone density caused by aging to improve male osteoporosis. Therefore, Bombycis Corpus may be used as a preventive and therapeutic agent for male osteoporosis.

Keywords

References

  1. National Health Insurance Statistics. 2007.
  2. Report of a WHO Study Group. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. World Health Organ Tech Rep Ser. 1994;843:1-129.
  3. Cecil RL, Wyngaarden JB, Smith LH, Bennett JC. Cecil textbook of medicine. 19th ed. Philadelphia: Saunders; 1992. p. 1426-31.
  4. Kim SY. A literature review and pilot study on risk factors of postmenopausal osteoporosis. Seoul National University Graduate School of Health: Department of Health Science. 1995.
  5. Choi EJ. A Study on the Correlation between Bone Mineral Density and Dietary Intake and Activity Status of Women after Menopause. Yonsei University Graduate School: Department of Food Science. 1987.
  6. Oh JW. Effects of Dietary Calcium on the Metabolism of Ca in the Experimental Model of Osteoporosis. Seoul National University Graduate School: Department of Agriculture and Family. 1991.
  7. Kannus P, Jarvinen M, Sievanen H, Oja P, Vuori I. Osteoporosis in men with a history of tibial fracture. J Bone Miner Res. 1994 Mar;9(3):423-9. https://doi.org/10.1002/jbmr.5650090319
  8. The Korean Society of Bone Metabolism Guidebook Compilation Committee. Physicians's guide for diagnosis & treatment of osteoporosis. Seoul: The Korean Society of Bone Metabolism; 2015.
  9. Marcus R, Feldman D, Kelsey J. Osteoporosis. 2nd ed. Sandiago: Academic press; 2001. p. 745.
  10. Kelepouris N, Harper KD, Gannon F, Kaplan FS, Haddad JG. Severe osteoporosis in men. Ann Intern Med. 1995 Sep 15;123(6):452-60. https://doi.org/10.7326/0003-4819-123-6-199509150-00010
  11. Cho ES. Prevalence and management of Osteoporosis: Korea National Health and Nutrition Examination Survey, 2008-2011. KCDC. 2013:1-5.
  12. Shin MK. Clinical traditional herbology. Seoul: Younglimsa;1992. pp.663-4.
  13. Shin GG. Shin's herbology. Seoul: Soomoonsa; 1973. p. 320-2.
  14. Kwon HC, Jung IY, Cho SY, Cho OR, Yang MC, Lee SO, et al. Phospholipids from Bombycis corpus and their neurotrophic effects. Arch Pharm Res. 2003 Jun;26(6):471-7. https://doi.org/10.1007/BF02976865
  15. Park JA. Effect of Bombycis corpus on osteoporosis experimental models. Kyunghee University Graduate School of East-West Medical Science: Department of Medical Science. 2008.
  16. Rhee SJ. A model for elderly health care management. Journal of Korean Academy of Public Health Nursing. 1994 Jun;8(2):71-82.
  17. Fujita T. Calcium and aging. Calcified Tissue International. 1985 Jan;37(1):1-2. https://doi.org/10.1007/BF02557669
  18. Riggs BL. Overview of osteoporosis. The Western Journal of Medicine. 1991 Jan; 154(1):63-77.
  19. Translated by professors from national medical university. Review of medical physiology. 18th ed. Seoul: Hanwoori; 2002. p. 412-6.
  20. Kim YA. Osteoporosis or Low Bone Mass in Adults Aged 50 years old and above in Republic of Korea, 2008-2011. Public health weekly report, KCDC. 2013;7(42):939-42.
  21. Cooper C, Campion G, Melton LJ 3rd. Hip fractures in the elderly: a world-wide projection. Osteoporos Int. 1992 Nov;2(6):285-9. https://doi.org/10.1007/BF01623184
  22. Martin AD, Silverthorn KG, Houston CS, Bernhardson S, Wajda A, Roos LL. The incidence of fracture of the proximal femur in two million Canadians from 1972 to 1984. Projections for Canada in the year 2006. Clin Orthop Relat Res. 1991 May;(266):111-8.
  23. Peris P, Guanabens N, Monegal A, Suris X, Alvarez L, Martinez de Osaba MJ, et al. Aetiology and presenting symptoms in male osteoporosis. Br J Rheumatol. 1995 Oct;34(10):936-41. https://doi.org/10.1093/rheumatology/34.10.936
  24. Jang JS, Moon SH. Measurement of Bone Mineral Density in Osteoporotic Fracture of the Spine using Dual Energy X-ray Absorptiometry -Evaluation of 154 Postmenopausal and senile Women-. J. of Korean Orthop. Assoc. 1992;27(1):57-64. https://doi.org/10.4055/jkoa.1992.27.1.57
  25. Kasugai S, Todescan R Jr, Nagata T, Yao KL, Butler WT, Sodek J. Expression of bone matrix proteins associated with mineralized tissue formation by adult rat bone marrow cells in vitro: inductive effects of dexamethasone on the osteoblastic phenotype. J Cell Physiol. 1991 Apr;147(1):111-20. https://doi.org/10.1002/jcp.1041470115
  26. Delmas PD. Biochemical markers of bone turnover. J Bone Miner Res. 1993 Dec;8 Suppl 2:S549-55. https://doi.org/10.1002/jbmr.5650081323
  27. Sherwood L. Human Physiology. 9th ed. Seoul: Life science; 2016. p. 788.
  28. Jones DH, Kong YY, Penninger JM. Role of RANKL and RANK in bone loss and arthritis. Ann Rheum Dis. 2002 Nov;61 Suppl 2:ii32-9. https://doi.org/10.1136/ard.61.suppl_2.ii32
  29. McClung M. Role of RANKL inhibition in osteoporosis. Arthritis Res Ther. 2007; 9(Suppl 1): S3. https://doi.org/10.1186/ar2167
  30. Kraus VB. Pathogenesis and treatment of osteoarthritis. Med Clin North Am. 1997 Jan;81(1):85-112. https://doi.org/10.1016/S0025-7125(05)70506-X
  31. Woessner JF Jr, Gunja-Smith Z. Role of metalloproteinases in human osteoarthritis. J Rheumatol Suppl. 1991 Feb;27:99-101.
  32. Bracco F, Scarpa M, Rigo A, Battistin L. Determination of superoxide dismutase activity by the polarographic method of catalytic currents in the cerebrospinal fluid of aging brain and neurologic degenerative diseases. Proc Soc Exp Biol Med. 1991 Jan;196(1):36-41. https://doi.org/10.3181/00379727-196-43160
  33. Dumuis A, Sebben M, Haynes L, Pin JP, Bockaert J. NMDA receptors activate the arachidonic acid cascade system in striatal neurons. Nature. 1988 Nov 3;336(6194):68-70. https://doi.org/10.1038/336068a0
  34. Compiled by the Institute of Medical Education. Elderly medicine. Seoul: Seoul National University Press; 1997. p. 3, 7, 9-10, 14, 22, 27, 29-31, 595.
  35. Nishizuka Y. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science. 1992 Oct 23;258(5082):607-14. https://doi.org/10.1126/science.1411571
  36. Beckman KB, Ames BN. The free radical theory of aging matures. Physiol Rev. 1998 Apr;78(2):547-81. https://doi.org/10.1152/physrev.1998.78.2.547
  37. Valko M, Izakovic M, Mazur M, Rhodes CJ, Telser J. Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem. 2004 Nov;266(1-2):37-56. https://doi.org/10.1023/B:MCBI.0000049134.69131.89
  38. Valavanidis A, Vlachogianni T, Fiotakis C. 8-hydroxy-2'-deoxyguanosine (8-OHdG): A critical biomarker of oxidative stress and carcinogenesis. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2009 Apr;27(2):120-39. https://doi.org/10.1080/10590500902885684

Cited by

  1. 골다공증의 한약 치료 효과: 국내 및 국외 동물 실험 및 임상 연구 논문에 대한 문헌 고찰 vol.31, pp.3, 2021, https://doi.org/10.18325/jkmr.2021.31.3.31