Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Arctii Lappa Fructus Extract Induces Lipogenesis through SREBP-1 Activation of Sebocytes

피지선세포에서 SREBP-1 활성에 의한 우방자추출물의 지질 생성 촉진 작용

  • In, Myung Hee (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Mun, Yeun Ja (Department of Herbal Resources, Professional Graduate School of Korean Medicine, Wonkwang University) ;
  • Woo, Won Hong (College of Korean Medicine, Wonkwang University)
  • 인명희 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 문연자 (원광대학교 한의학전문대학원 한약자원개발학과) ;
  • 우원홍 (원광대학교 한의과대학)
  • Received : 2019.09.18
  • Accepted : 2020.02.21
  • Published : 2020.02.25
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Abstract

Arctii Lappa Fructus has the numerous health benefits, including antioxidant, anti-inflammatory, and anti-carcinogenic properties. Skin lipids are one of several factors that maintain epidermal barrier function. This study was to explore the lipogenic effect by ethanol extract of Arctii Lappa Fructus (EAF) in sebocytes. First, it was confirmed that EAF exhibited high antioxidant activity and collagenase activity inhibition. We found that cholesterol and triglyceride levels of cells by EAF were increased significantly in a dose-dependent manner. Moreover, EAF increased the expression of transcription factor sterol regulatory element-binding protein-1 (SREBP-1) in the cells. These results suggest that EAF induces lipogenesis in cells through the activation of SREBP-1.

Keywords

References

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