Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of Nature Herb Mixture Containing Laminaria japonica Areschoung on Fine Dust-induced Bronchitis in Mice

미세먼지로 유도된 기관지염증에 다시마가 함유된 복합물의 효과

  • Han, Su-Hyun (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Joo, In-Hwan (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Lee, Su-Bin (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Kim, Dong-Hee (Department of Pathology, College of Korean Medicine, Daejeon University) ;
  • Hyun, Ju-Myung (MJ Blooming R&D Inc) ;
  • Park, Jong-Min (Department of Pathology, College of Korean Medicine, Daejeon University)
  • 한수현 (대전대학교 한의과대학 병리학교실) ;
  • 주인환 (대전대학교 한의과대학 병리학교실) ;
  • 이수빈 (대전대학교 한의과대학 병리학교실) ;
  • 김동희 (대전대학교 한의과대학 병리학교실) ;
  • 현주명 ((주)엠제이블루밍알앤디) ;
  • 박종민 (대전대학교 한의과대학 병리학교실)
  • Received : 2020.07.21
  • Accepted : 2020.09.18
  • Published : 2020.10.25
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Abstract

The purpose of this study was to investigate the effects of natural herb mixture containing Laminaria japonica Areschoung (LAM) on fine dust-induced bronchitis in mice. Laminaria japonica Areschoung is main content of LAM, which is including fucoidan. Fucoidan extracted from phaophyta is known to prevent bronchitis and to defend against bacteria and virus infection. In this study, we experienced the effect of LAM on bronchitis and investigated gene expressions (e.g ; IL-8, COX-2, MCP-1) and bio-markers (e.g ; IL-8, PGE2, MUC5AC) associated with bronchitis by using A549 cells. Also, we investigated whether LAM can suppress the bronchitis in fine dust-induced animal models. We injected fine dust (50 ㎕) twice as INT (Intra-Nasal-Trachea) method. Then LAM (200 mg/kg and 400 mg/kg) were oral administered for 14 days. We analyzed the number of immune cells, immunoglobulin E, bio-markers level associated with bronchitis. LAM significantly decreased bio-marker (IL-1β, IL-6, IL-8, TNF-α, Histamine, PGE2), immune cells (white blood cell, neutrophil, lymphocyte, monocyte), and immunoglobulin E, that are increased by fine dust. Taken together, this study suggest that LAM can be used as effective herbal extract for bronchitis.

Keywords

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