Pediatric Gastroenterology, Hepatology & Nutrition

  • 제23권2호
  • /
  • Pages.121-131
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  • 2020
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  • 2234-8646(pISSN)
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  • 2234-8840(eISSN)
대한소아소화기영양학회 (The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition)
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Long-Term Efficacy of Anti-Tumor Necrosis Factor Agents in Pediatric Luminal Crohn's Disease: A Systematic Review of Real-World Evidence Studies

  • Rheenen, Hanna van (Amsterdam University Medical Centers, Location VU Medical Centre) ;
  • Rheenen, Patrick Ferry van (Department of Paediatric Gastroenterology, Hepatology and Nutrition, University of Groningen, University Medical Centre Groningen)
  • 투고 : 2019.12.18
  • 심사 : 2020.02.05
  • 발행 : 2020.03.15
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초록

Purpose: To determine the long-term efficacy of the anti-tumor necrosis factor (TNF) agents, infliximab (IFX) and adalimumab (ADA), in pediatric luminal Crohn's disease (CD) by performing a systematic literature review. Methods: An electronic search was performed in Medline, Embase, and the Cochrane Library from inception to September 26, 2019. Eligible studies were cohort studies with observation periods that exceeded 1 year. Studies that reported time-to-event analyses were included. Events were defined as discontinuation of anti-TNF therapy for secondary loss of response. We extracted the probabilities of continuing anti-TNF therapy 1, 2, and 3 years after initiation. Results: In total, 2,464 papers were screened, 94 were selected for full text review, and 13 studies (11 on IFX, 2 on ADA) met our eligibility criteria for inclusion. After 1 year, 83-97% of patients were still receiving IFX therapy. After 2 and 3 years the probability of continuing IFX therapy decreased to 67-91% and 61-85%, respectively. In total, 5 of the 11 studies subgrouped by concomitant medication consistently showed that the probabilities of continuing IFX therapy in patients with prolonged immunomodulator use were higher than those in patients on IFX monotherapy. Conclusion: This review of real-world evidence studies confirms the long-term therapeutic benefit of IFX therapy in diverse cohorts of children with luminal CD. Moreover, it supports the view that combination therapy with an immunomodulator prolongs the durability of IFX therapy in patients who previously failed to recover following first-line therapy. The limited number of time-to-event studies in patients on ADA prevented us from drawing definite conclusions about its long-term efficacy.

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참고문헌

  1. Ruemmele FM, Veres G, Kolho KL, Griffiths A, Levine A, Escher JC, et al.; European Crohn's and Colitis Organisation; European Society of Pediatric Gastroenterology, Hepatology and Nutrition. Consensus guidelines of ECCO/ESPGHAN on the medical management of pediatric Crohn's disease. J Crohns Colitis 2014;8:1179-207. https://doi.org/10.1016/j.crohns.2014.04.005
  2. Mack DR, Benchimol EI, Critch J, deBruyn J, Tse F, Moayyedi P, et al. Canadian Association of Gastroenterology clinical practice guideline for the medical management of pediatric luminal Crohn's disease. Gastroenterology 2019;157:320-48. https://doi.org/10.1053/j.gastro.2019.03.022
  3. Hyams J, Crandall W, Kugathasan S, Griffiths A, Olson A, Johanns J, et al.; REACH Study Group. Induction and maintenance infliximab therapy for the treatment of moderate-to-severe Crohn's disease in children. Gastroenterology 2007;132:863-73; quiz 1165-6. https://doi.org/10.1053/j.gastro.2006.12.003
  4. Hyams JS, Griffiths A, Markowitz J, Baldassano RN, Faubion WA Jr, Colletti RB, et al. Safety and efficacy of adalimumab for moderate to severe Crohn's disease in children. Gastroenterology 2012;143:365-74.e2. https://doi.org/10.1053/j.gastro.2012.04.046
  5. Bramer WM, Giustini D, de Jonge GB, Holland L, Bekhuis T. De-duplication of database search results for systematic reviews in EndNote. J Med Libr Assoc 2016;104:240-3. https://doi.org/10.3163/1536-5050.104.3.014
  6. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan-a web and mobile app for systematic reviews. Syst Rev 2016;5:210. https://doi.org/10.1186/s13643-016-0384-4
  7. Tierney JF, Stewart LA, Ghersi D, Burdett S, Sydes MR. Practical methods for incorporating summary time-to-event data into meta-analysis. Trials 2007;8:16. https://doi.org/10.1186/1745-6215-8-16
  8. Hyams JS, Lerer T, Griffiths A, Pfefferkorn M, Kugathasan S, Evans J, et al.; Pediatric Inflammatory Bowel Disease Collaborative Research Group. Long-term outcome of maintenance infliximab therapy in children with Crohn's disease. Inflamm Bowel Dis 2009;15:816-22. https://doi.org/10.1002/ibd.20845
  9. de Bie CI, Hummel TZ, Kindermann A, Kokke FT, Damen GM, Kneepkens CM, et al. The duration of effect of infliximab maintenance treatment in paediatric Crohn's disease is limited. Aliment Pharmacol Ther 2011;33:243-50. https://doi.org/10.1111/j.1365-2036.2010.04507.x
  10. Gouldthorpe O, Catto-Smith AG, Alex G, Simpson D. Loss of response to long-term infliximab therapy in children with Crohn's disease. Pharmaceuticals (Basel) 2013;6:1322-34. https://doi.org/10.3390/ph6101322
  11. Vahabnezhad E, Rabizadeh S, Dubinsky MC. A 10-year, single tertiary care center experience on the durability of infliximab in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2014;20:606-13. https://doi.org/10.1097/MIB.0000000000000003
  12. Church PC, Guan J, Walters TD, Frost K, Assa A, Muise AM, et al. Infliximab maintains durable response and facilitates catch-up growth in luminal pediatric Crohn's disease. Inflamm Bowel Dis 2014;20:1177-86. https://doi.org/10.1097/MIB.0000000000000083
  13. Grover Z, Biron R, Carman N, Lewindon P. Predictors of response to Infliximab in children with luminal Crohn's disease. J Crohn's Colitis 2014;8:739-46. https://doi.org/10.1016/j.crohns.2013.12.017
  14. Grossi V, Lerer T, Griffiths A, LeLeiko N, Cabrera J, Otley A, et al. Concomitant use of immunomodulators affects the durability of infliximab therapy in children with Crohn's disease. Clin Gastroenterol Hepatol 2015;13:1748-56. https://doi.org/10.1016/j.cgh.2015.04.010
  15. Lee YM, Kang B, Lee Y, Kim MJ, Choe YH. Infliximab "top-down" strategy is superior to "step-up" in maintaining long-term remission in the treatment of pediatric crohn disease. J Pediatr Gastroenterol Nutr 2015;60:737-43. https://doi.org/10.1097/MPG.0000000000000711
  16. Dupont-Lucas C, Sternszus R, Ezri J, Leibovitch S, Gervais F, Amre D, et al. Identifying patients at high risk of loss of response to infliximab maintenance therapy in paediatric Crohn's disease. J Crohn's Colitis 2016;10:795-804. https://doi.org/10.1093/ecco-jcc/jjw038
  17. Cheng J, Hamilton Z, Smyth M, Barker C, Israel D, Jacobson K. Concomitant therapy with immunomodulator enhances infliximab durability in pediatric inflammatory bowel disease. Inflamm Bowel Dis 2017;23:1762-73. https://doi.org/10.1097/MIB.0000000000001212
  18. deBruyn JC, Jacobson K, El-Matary W, Carroll M, Wine E, Wrobel I, et al. Long-term outcomes of infliximab use for pediatric Crohn disease: a canadian multicenter clinical practice experience. J Pediatr Gastroenterol Nutr 2018;66:268-73. https://doi.org/10.1097/MPG.0000000000001672
  19. Rosh JR, Lerer T, Markowitz J, Goli SR, Mamula P, Noe JD, et al. Retrospective evaluation of the safety and effect of adalimumab therapy (RESEAT) in pediatric Crohn's disease. Am J Gastroenterol 2009;104:3042-9. https://doi.org/10.1038/ajg.2009.493
  20. Cozijnsen M, Duif V, Kokke F, Kindermann A, van Rheenen P, de Meij T, et al.; Dutch PIBD Working Group Kids with Crohn and Colitis. Adalimumab therapy in children with Crohn disease previously treated with infliximab. J Pediatr Gastroenterol Nutr 2015;60:205-10. https://doi.org/10.1097/MPG.0000000000000589
  21. Li S, Reynaert C, Su AL, Sawh S. Efficacy and safety of infliximab in pediatric Crohn disease: a systematic review and meta-analysis. Can J Hosp Pharm 2019;72:227-38.
  22. Dziechciarz P, Horvath A, Kierkus J. Efficacy and safety of adalimumab for paediatric Crohn's disease: a systematic review. J Crohn's Colitis 2016;10:1237-44. https://doi.org/10.1093/ecco-jcc/jjw077
  23. Assa A, Matar M, Turner D, Broide E, Weiss B, Ledder O, et al. Proactive monitoring of adalimumab trough concentration associated with increased clinical remission in children with Crohn's disease compared with reactive monitoring. Gastroenterology 2019;157:985-996.e2. https://doi.org/10.1053/j.gastro.2019.06.003
  24. Frymoyer A, Piester TL, Park KT. Infliximab dosing strategies and predicted trough exposure in children with Crohn disease. J Pediatr Gastroenterol Nutr 2016;62:723-7. https://doi.org/10.1097/MPG.0000000000001123

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