The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
권호 표지
DOI QR코드

DOI QR Code

Changes in plasma lipoxin A4, resolvins and CD59 levels after ischemic and traumatic brain injuries in rats

  • Jung, Jun-Sub (Institute of Natural Medicine, College of Medicine, Hallym University) ;
  • Kho, A Ra (Department of Physiology, College of Medicine, Hallym University) ;
  • Lee, Song Hee (Department of Physiology, College of Medicine, Hallym University) ;
  • Choi, Bo Young (Department of Physiology, College of Medicine, Hallym University) ;
  • Kang, Shin-Hae (Department of Pharmacology, College of Medicine, Hallym University) ;
  • Koh, Jae-Young (Department of Neurology, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Suh, Sang Won (Department of Physiology, College of Medicine, Hallym University) ;
  • Song, Dong-Keun (Department of Pharmacology, College of Medicine, Hallym University)
  • Received : 2019.09.09
  • Accepted : 2019.12.20
  • Published : 2020.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

Ischemic and traumatic brain injuries are the major acute central nervous system disorders that need to be adequately diagnosed and treated. To find biomarkers for these acute brain injuries, plasma levels of some specialized pro-resolving mediators (SPMs, i.e., lipoxin A4 [LXA4], resolvin [Rv] E1, RvE2, RvD1 and RvD2), CD59 and interleukin (IL)-6 were measured at 0, 6, 24, 72, and 168 h after global cerebral ischemic (GCI) and traumatic brain injuries (TBI) in rats. Plasma LXA4 levels tended to increase at 24 and 72 h after GCI. Plasma RvE1, RvE2, RvD1, and RvD2 levels showed a biphasic response to GCI; a significant decrease at 6 h with a return to the levels of the sham group at 24 h, and again a decrease at 72 h. Plasma CD59 levels increased at 6 and 24 h post-GCI, and returned to basal levels at 72 h post-GCI. For TBI, plasma LXA4 levels tended to decrease, while RvE1, RvE2, RvD1, and RvD2 showed barely significant changes. Plasma IL-6 levels were significantly increased after GCI and TBI, but with different time courses. These results show that plasma LXA4, RvE1, RvE2, RvD1, RvD2, and CD59 levels display differential responses to GCI and TBI, and need to be evaluated for their usefulness as biomarkers.

Keywords

References

  1. Chou SH, Robertson CS; Participants in the International Multidisciplinary Consensus Conference on the Multimodality Monitoring. Monitoring biomarkers of cellular injury and death in acute brain injury. Neurocrit Care. 2014;21 Suppl 2:S187-214.
  2. Mrozek S, Dumurgier J, Citerio G, Mebazaa A, Geeraerts T. Biomarkers and acute brain injuries: interest and limits. Crit Care. 2014;18:220. https://doi.org/10.1186/cc13841
  3. Dalli J, Kraft BD, Colas RA, Shinohara M, Fredenburgh LE, Hess DR, Chiang N, Welty-Wolf K, Choi AM, Piantadosi CA, Serhan CN. The regulation of proresolving lipid mediator profiles in baboon pneumonia by inhaled carbon monoxide. Am J Respir Cell Mol Biol. 2015;53:314-25. https://doi.org/10.1165/rcmb.2014-0299OC
  4. Perucci LO, Santos PC, Ribeiro LS, Souza DG, Gomes KB, Dusse LM, Sousa LP. Lipoxin A4 is increased in the plasma of preeclamptic women. Am J Hypertens. 2016;29:1179-85. https://doi.org/10.1093/ajh/hpw053
  5. Barden AE, Moghaddami M, Mas E, Phillips M, Cleland LG, Mori TA. Specialised pro-resolving mediators of inflammation in inflammatory arthritis. Prostaglandins Leukot Essent Fatty Acids. 2016;107:24-9. https://doi.org/10.1016/j.plefa.2016.03.004
  6. Bazan HA, Lu Y, Jun B, Fang Z, Woods TC, Hong S. Circulating inflammation-resolving lipid mediators RvD1 and DHA are decreased in patients with acutely symptomatic carotid disease. Prostaglandins Leukot Essent Fatty Acids. 2017;125:43-7. https://doi.org/10.1016/j.plefa.2017.08.007
  7. Barden A, Shinde S, Phillips M, Beilin L, Mas E, Hodgson JM, Puddey I, Mori TA. The effects of alcohol on plasma lipid mediators of inflammation resolution in patients with Type 2 diabetes mellitus. Prostaglandins Leukot Essent Fatty Acids . 2018;133:29-34. https://doi.org/10.1016/j.plefa.2018.04.004
  8. Dilek F, Ozceker D, Guler EM, Ozkaya E, Yazici M, Tamay Z, Kocyigit A, Guler N. Plasma lipoxin A4 levels in childhood chronic spontaneous urticaria. Turk J Pediatr. 2018;60:527-34. https://doi.org/10.24953/turkjped.2018.05.009
  9. Kimberley FC, Sivasankar B, Paul Morgan B. Alternative roles for CD59. Mol Immunol. 2007;44:73-81. https://doi.org/10.1016/j.molimm.2006.06.019
  10. Vakeva A, Lehto T, Takala A, Meri S. Detection of a soluble form of the complement membrane attack complex inhibitor CD59 in plasma after acute myocardial infarction. Scand J Immunol. 2000;52:411-4. https://doi.org/10.1046/j.1365-3083.2000.00783.x
  11. Fassbender K, Rossol S, Kammer T, Daffertshofer M, Wirth S, Dollman M, Hennerici M. Proinflammatory cytokines in serum of patients with acute cerebral ischemia: kinetics of secretion and relation to the extent of brain damage and outcome of disease. J Neurol Sci. 1994;122:135-9. https://doi.org/10.1016/0022-510X(94)90289-5
  12. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR. Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol. 1995;37:800-5. https://doi.org/10.1002/ana.410370614
  13. Tuttolomondo A, Di Raimondo D, di Sciacca R, Pinto A, Licata G. Inflammatory cytokines in acute ischemic stroke. Curr Pharm Des. 2008;14:3574-89. https://doi.org/10.2174/138161208786848739
  14. McClain C, Cohen D, Phillips R, Ott L, Young B. Increased plasma and ventricular fluid interleukin-6 levels in patients with head injury. J Lab Clin Med. 1991;118:225-31.
  15. Kossmann T, Hans VH, Imhof HG, Stocker R, Grob P, Trentz O, Morganti-Kossmann C. Intrathecal and serum interleukin-6 and the acute-phase response in patients with severe traumatic brain injuries. Shock. 1995;4:311-7. https://doi.org/10.1097/00024382-199511000-00001
  16. Aisiku IP, Yamal JM, Doshi P, Benoit JS, Gopinath S, Goodman JC, Robertson CS. Plasma cytokines IL-6, IL-8, and IL-10 are associated with the development of acute respiratory distress syndrome in patients with severe traumatic brain injury. Crit Care. 2016;20:288. https://doi.org/10.1186/s13054-016-1470-7
  17. Suh SW, Shin BS, Ma H, Van Hoecke M, Brennan AM, Yenari MA, Swanson RA. Glucose and NADPH oxidase drive neuronal superoxide formation in stroke. Ann Neurol. 2008;64:654-63. https://doi.org/10.1002/ana.21511
  18. Hong DK, Choi BY, Kho AR, Lee SH, Jeong JH, Kang BS, Kang DH, Park KH, Suh SW. Carvacrol attenuates hippocampal neuronal death after global cerebral ischemia via inhibition of transient receptor potential melastatin 7. Cells. 2018;7:E231.
  19. Choi BY, Jang BG, Kim JH, Lee BE, Sohn M, Song HK, Suh SW. Prevention of traumatic brain injury-induced neuronal death by inhibition of NADPH oxidase activation. Brain Res. 2012;1481:49-58. https://doi.org/10.1016/j.brainres.2012.08.032
  20. Choi BY, Lee SH, Choi HC, Lee SK, Yoon HS, Park JB, Chung WS, Suh SW. Alcohol dependence treating agent, acamprosate, prevents traumatic brain injury-induced neuron death through vesicular zinc depletion. Transl Res. 2019;207:1-18. https://doi.org/10.1016/j.trsl.2019.01.002
  21. Schmued LC, Hopkins KJ. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res. 2000;874:123-30. https://doi.org/10.1016/S0006-8993(00)02513-0
  22. Jing L, He Q, Zhang JZ, Li PA. Temporal profile of astrocytes and changes of oligodendrocyte-based myelin following middle cerebral artery occlusion in diabetic and non-diabetic rats. Int J Biol Sci. 2013;9:190-9. https://doi.org/10.7150/ijbs.5844
  23. Loane DJ, Kumar A, Stoica BA, Cabatbat R, Faden AI. Progressive neurodegeneration after experimental brain trauma: association with chronic microglial activation. J Neuropathol Exp Neurol. 2014; 73:14-29. https://doi.org/10.1097/NEN.0000000000000021
  24. Souza DG, Fagundes CT, Amaral FA, Cisalpino D, Sousa LP, Vieira AT, Pinho V, Nicoli JR, Vieira LQ, Fierro IM, Teixeira MM. The required role of endogenously produced lipoxin A4 and annexin-1 for the production of IL-10 and inflammatory hyporesponsiveness in mice. J Immunol. 2007;179:8533-43. https://doi.org/10.4049/jimmunol.179.12.8533
  25. Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K, Musto A, Hardy M, Gimenez JM, Chiang N, Serhan CN, Bazan NG. Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem. 2003;278:43807-17. https://doi.org/10.1074/jbc.M305841200