Journal of the Korean Society of Food Culture (한국식생활문화학회지)

Korean Society of Food Culture (한국식생활문화학회)
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Fatty Acid Concentration of Serum Phospholipids in Normal and Glaucoma Patients

정상인과 녹내장 환자의 혈청 인지질 지방산 농도

  • Received : 2020.03.26
  • Accepted : 2020.04.29
  • Published : 2020.04.30
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Abstract

Glaucoma is one of the leading causes of blindness worldwide and is characterized by degeneration of the optic nerve. Elevated intraocular pressure (IOP) is the major contributing factor to optic nerve damage. However, some patients develop glaucoma even with normal IOP. Other factors, including age, race, myopia, and nutrition, can affect glaucoma risk. Dietary fat intake and serum fatty acid composition are closely related with the fatty acid profile of the retina and thus can modulate glaucoma risk. In this study, we collected serum samples from 34 glaucoma patients (26 primary open angle glaucoma (POAG) and 8 normal tension glaucoma (NTG)) and 45 healthy controls and analyzed their serum phospholipid fatty acid concentrations. The results show that the ratio of oleic acid to stearic acid (OA/SA), which is an indicator of stearoyl-CoA desaturase activity, was higher in POAG patients when compared to normal controls. The ratio of eicosapentaenoic acid to arachidonic acid (EPA/AA), which is an indirect marker of eicosanoid biosynthesis, was also higher in glaucoma patients (p=0.048). These results imply that dietary fatty acid intake and serum fatty acid profile can influence glaucoma risk. Additional study is necessary to identify the relationship between fatty acids and glaucoma.

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References

  1. Acar N, Berdeaux O, Grgoire S, Cabaret S, Martine L, Gain P, Thuret G, Creuzot-Garcher CP, Bron AM, Bretillon L. 2012. Lipid composition of the human eye: are red blood cells a good mirror of retinal and optic nerve fatty acids? PLoS One, 7(4):e35102 https://doi.org/10.1371/journal.pone.0035102
  2. Baylin A, Campos H. 2006. The use of fatty acid biomarkers to reflect dietary intake. Curr. Opin. Lipidol., 17(1):22-27 https://doi.org/10.1097/01.mol.0000199814.46720.83
  3. Cho HK, Kee C. 2014. Population-based glaucoma prevalence studies in Asians. Surv. Ophthalmol., 59(4):434-447 https://doi.org/10.1016/j.survophthal.2013.09.003
  4. Chong EW, Kreis AJ, Wong TY, Simpson JA, Guymer RH. 2008. Dietary omega-3 fatty acid and fish intake in the primary prevention of age-related macular degeneration: a systematic review and meta-analysis. Arch. Ophthalmol., 126(6):826-833 https://doi.org/10.1001/archopht.126.6.826
  5. Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D. 2019. Lipidomic analysis of ${\alpha}$-synuclein neurotoxicity identifies stearoyl CoA desaturase as a target for parkinson treatment. Mol. Cell, 73(5):1001-1014 https://doi.org/10.1016/j.molcel.2018.11.028
  6. Faralli JA, Filla MS, Peters DM. 2019. Role of fibronectin in primary open angle glaucoma. Cells, 8(12). pii: E1518
  7. Flammer J, Orgl S, Costa VP, Orzalesi N, Krieglstein GK, Serra LM, Renard JP, Stefnsson E. 2002. The impact of ocular blood flow in glaucoma. Prog. Retin. Eye Res., 21(4):359-393 https://doi.org/10.1016/S1350-9462(02)00008-3
  8. Fliesler SJ, Anderson RE. 1983. Chemistry and metabolism of lipids in the vertebrate retina. Prog. Lipid Res., 22(2):79-131 https://doi.org/10.1016/0163-7827(83)90004-8
  9. Folch J, Ascoli I, Lee SM, Meath JA, LeBaron N. 1951. Preparation of lipide extracts from brain tissue. J. Biol. Chem., 191(2):833-841 https://doi.org/10.1016/S0021-9258(18)55987-1
  10. Greiner CA, Greiner JV, Leahy CD, Auerbach DB, Marcus MD, Davies LH, Rodriguez W, Glonek T. 1995. Distribution of membrane phospholipids in the rabbit neural retina, optic nerve head and optic nerve. Int. J. Biochem. Cell Biol., 27(1):21-28 https://doi.org/10.1016/1357-2725(94)00061-1
  11. Heintz N, Zoghbi H. 1997. alpha-Synuclein--a link between Parkinson and Alzheimer diseases? Nat. Genet., 16(4):325-327 https://doi.org/10.1038/ng0897-325
  12. Higginbotham EJ, Gordon MO, Beiser JA, Drake MV, Bennett GR, Wilson MR, Kass MA; Ocular Hypertension Treatment Study Group. 2004. The Ocular Hypertension Treatment Study: topical medication delays or prevents primary open-angle glaucoma in African American individuals. Arch. Ophthalmol., 122(6):813-820 https://doi.org/10.1001/archopht.122.6.813
  13. Hoffman DR, Boettcher JA, Diersen-Schade DA. 2009. Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials. Prostaglandins Leukot. Essent. Fatty Acids, 81(2-3):151-158 https://doi.org/10.1016/j.plefa.2009.05.003
  14. Innis SM. 1996. Essential dietary lipids. In: Ziegler EE, Filer LJ, eds. Present knowledge in nutrition. 7th ed. ILSI Press, Washington, DC, USA, pp 58-66
  15. Innis SM. 2008. Dietary omega 3 fatty acids and the developing brain. Brain Res., 1237:35-43 https://doi.org/10.1016/j.brainres.2008.08.078
  16. Innis SM, Dyer RA. 2002. Brain astrocyte synthesis of docosahexaenoic acid from n-3 fatty acids is limited at the elongation of docosapentaenoic acid. J. Lipid Res., 43(9):1529-1536 https://doi.org/10.1194/jlr.M200120-JLR200
  17. James MJ, Gibson RA, Cleland LG. 2000. Dietary polyunsaturated fatty acids and inflammatory mediator production. Am. J. Clin. Nutr., 71(1suppl):343S-348S https://doi.org/10.1093/ajcn/71.1.343s
  18. Kang JH, Pasquale LR, Willett WC, Rosner BA, Egan KM, Faberowski N, Hankinson SE. 2004. Dietary fat consumption and primary open-angle glaucoma. Am. J. Clin. Nutr., 79(5):755-764 https://doi.org/10.1093/ajcn/79.5.755
  19. Kris-Etherton PM, Harris WS, Appel LJ. 2002. Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation, 106(21):2747-2757 https://doi.org/10.1161/01.CIR.0000038493.65177.94
  20. Lee BL, Bathija R, Weinreb RN. 1998. The definition of normal-tension glaucoma. J. Glaucoma, 7(6):366-371
  21. McMonnies CW. 2017. Glaucoma history and risk factors. J. Optom., 10(2):71-78 https://doi.org/10.1016/j.optom.2016.02.003
  22. Merle BM, Benlian P, Puche N, Bassols A, Delcourt C, Souied EH; Nutritional AMD Treatment 2 Study Group. 2014. Circulating omega-3 Fatty acids and neovascular age-related macular degeneration. Invest. Ophthalmol. Vis. Sci., 55(3):2010-2019 https://doi.org/10.1167/iovs.14-13916
  23. Mozaffarieh M, Flammer J. 2007. A novel perspective on natural therapeutic approaches in glaucoma therapy. Expert. Opin. Emerg. Drugs, 12(2):195-198 https://doi.org/10.1517/14728214.12.2.195
  24. Nucci C, Russo R, Martucci A, Giannini C, Garaci F, Floris R, Bagetta G, Morrone LA. 2016. New strategies for neuroprotection in glaucoma, a disease that affects the central nervous system. Eur. J. Pharmacol., 787:119-126 https://doi.org/10.1016/j.ejphar.2016.04.030
  25. Paton CM, Ntambi JM. 2009. Biochemical and physiological function of stearoyl-CoA desaturase. Am. J. Physiol. Endocrinol. Metab., 297(1):E28-E37 https://doi.org/10.1152/ajpendo.90897.2008
  26. Pelletier AL, Rojas-Roldan L, Coffin J. 2016. Vision loss in older adults. Am. Fam. Physician, 94(3):219-226
  27. Prez de Arcelus M, Toledo E, Martnez-Gonzlez M, Sayn-Orea C, Gea A, Moreno-Montas J. 2014. Omega 3:6 ratio intake and incidence of glaucoma: the SUN cohort. Clin. Nutr., 33(6):1041-1045 https://doi.org/10.1016/j.clnu.2013.11.005
  28. Quigley HA, Broman AT. 2006. The number of people with glaucoma worldwide in 2010 and 2020. Br. J. Ophthalmol., 90(3):262-267 https://doi.org/10.1136/bjo.2005.081224
  29. Ramdas WD. 2018. The relation between dietary intake and glaucoma: a systematic review. Acta. Ophthalmol., 96(6):550-556 https://doi.org/10.1111/aos.13662
  30. Ramdas WD, Wolfs RC, Kiefte-de Jong JC, Hofman A, de Jong PT, Vingerling JR, Jansonius NM. 2012. Nutrient intake and risk of open-angle glaucoma: the Rotterdam Study. Eur. J. Epidemiol., 27(5):385-393 https://doi.org/10.1007/s10654-012-9672-z
  31. Ren H, Magulike N, Ghebremeskel K, Crawford M. 2006. Primary open-angle glaucoma patients have reduced levels of blood docosahexaenoic and eicosapentaenoic acids. Prostaglandins Leukot. Essent. Fatty Acids, 74(3):157-163 https://doi.org/10.1016/j.plefa.2005.11.007
  32. Renard JP, Rouland JF, Bron A, Sellem E, Nordmann JP, Baudouin C, Denis P, Villain M, Chaine G, Colin J, de Pouvourville G, Pinchinat S, Moore N, Estephan M, Delcourt C. 2013. Nutritional, lifestyle and environmental factors in ocular hypertension and primary open-angle glaucoma: an exploratory case-control study. Acta. Ophthalmol., 91(6):505-513 https://doi.org/10.1111/j.1755-3768.2011.02356.x
  33. Resch H, Garhofer G, Fuchsjager-Mayrl G, Hommer A, Schmetterer L. 2009. Endothelial dysfunction in glaucoma. Acta. Ophthalmol., 87(1):4-12 https://doi.org/10.1111/j.1755-3768.2007.01167.x
  34. SanGiovanni JP, Chew EY. 2005. The role of omega-3 longchain polyunsaturated fatty acids in health and disease of the retina. Prog. Retin. Eye Res., 24(1):87-138 https://doi.org/10.1016/j.preteyeres.2004.06.002
  35. Semenova EM, Converse CA. 2003. Comparison between oleic acid and docosahexaenoic acid binding to interphotoreceptor retinoid-binding protein. Vision Res., 43(28):3063-3067 https://doi.org/10.1016/j.visres.2003.09.008
  36. Seo SJ, Lee YH, Lee SY, Bae HW, Hong S, Seong GJ, Kim CY. 2016. Estimated prevalence of glaucoma in South Korea using the national claims database. J. Ophthalmol., 2016:1690256
  37. Simopoulos AP. 2008. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac J Clin Nutr., 17 Suppl 1:131-134
  38. Stjernschantz JW. 2001. From PGF(2alpha)-isopropyl ester to latanoprost: a review of the development of Xalatan. Invest. Ophthalmol. Vis. Sci., 42(6):1134-1145
  39. Thibaut AC, Rotival M, Gauthier E, Lenoir GM, Boutron-Ruault MC, Joulin V, Clavel-Chapelon F, Chajs V. 2009. Correlation between serum phospholipid fatty acids and dietary intakes assessed a few years earlier. Nutr. Cancer, 61(4):500-509 https://doi.org/10.1080/01635580802710717
  40. Varma R, Ying-Lai M, Francis BA, Nguyen BB, Deneen J, Wilson MR, Azen SP; Los Angeles Latino Eye Study Group. 2004. Prevalence of open-angle glaucoma and ocular hypertension in Latinos: the Los Angeles Latino Eye Study. Ophthalmology, 111(8):1439-1448 https://doi.org/10.1016/j.ophtha.2004.01.025
  41. Weinreb RN, Aung T, Medeiros FA. 2014. The pathophysiology and treatment of glaucoma: a review. JAMA, 311(18):1901-1911 https://doi.org/10.1001/jama.2014.3192
  42. Yehuda S, Rabinovitz S, Carasso RL, Mostofsky DI. 2002. The role of polyunsaturated fatty acids in restoring the aging neuronal membrane. Neurobiol. Aging, 23(5):843-853 https://doi.org/10.1016/S0197-4580(02)00074-X
  43. Korea ministry of health & welfare. 2015 KDRIs, Dietary reference intakes for Koreans. Available from: http://www.korea.kr, [accessed 2020.2.1]