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Adjuvant Therapy for Esophageal Squamous Cell Carcinoma

  • Sun, Jong-Mu (Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Received : 2020.05.12
  • Accepted : 2020.05.20
  • Published : 2020.08.05

Abstract

Adjuvant therapy for completely resected esophageal squamous cell carcinoma is less commonly applied in clinical practice than neoadjuvant therapy, but it plays a substantial role in improving survival for esophageal cancer patients. This article presents a concise review of the evidence regarding adjuvant therapy for esophageal squamous cell carcinoma and future directions, particularly immunotherapy.

Keywords

References

  1. Cancer Information Service. Esophageal cancer [Internet]. Goyang: Cancer Information Service; 2019 [cited 2020 Mar 20]. Available from: https://www.cancer.go.kr/lay1/program/S1T211C223/cancer/view.do?cancer_seq=4277&menu_seq=4282.
  2. Cook MB, Chow WH, Devesa SS. Oesophageal cancer incidence in the United States by race, sex, and histologic type, 1977-2005. Br J Cancer 2009;101:855-9. https://doi.org/10.1038/sj.bjc.6605246
  3. Bang YJ, Kim YW, Yang HK, et al. Adjuvant capecitabine and oxaliplatin for gastric cancer after D2 gastrectomy (CLASSIC): a phase 3 open-label, randomised controlled trial. Lancet 2012;379:315-21. https://doi.org/10.1016/S0140-6736(11)61873-4
  4. Park SH, Sohn TS, Lee J, et al. Phase III trial to compare adjuvant chemotherapy with capecitabine and cisplatin versus concurrent chemoradiotherapy in gastric cancer: final report of the adjuvant chemoradiotherapy in stomach tumors trial, including survival and subset analyses. J Clin Oncol 2015;33:3130-6. https://doi.org/10.1200/JCO.2014.58.3930
  5. Ando N, Iizuka T, Ide H, et al. Surgery plus chemotherapy compared with surgery alone for localized squamous cell carcinoma of the thoracic esophagus: a Japan Clinical Oncology Group Study JCOG9204. J Clin Oncol 2003;21:4592-6. https://doi.org/10.1200/jco.2003.12.095
  6. Ando N, Kato H, Igaki H, et al. A randomized trial comparing postoperative adjuvant chemotherapy with cisplatin and 5-fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (JCOG9907). Ann Surg Oncol 2012;19:68-74. https://doi.org/10.1245/s10434-011-2049-9
  7. Van Hagen P, Hulshof MC, van Lanschot JJ, et al. Preoperative chemoradiotherapy for esophageal or junctional cancer. N Engl J Med 2012;366:2074-84. https://doi.org/10.1056/NEJMoa1112088
  8. National Comprehensive Cancer Network. Esophageal and esophagogastric junction cancers [Internet]. Plymouth Meeting (PA): National Comprehensive Cancer Network [cited 2020 Mar 20]. Available from: https://www.nccn.org/professionals/physician_gls/pdf/esophageal.pdf.
  9. Stahl M, Mariette C, Haustermans K, Cervantes A, Arnold D; ESMO Guidelines Working Group. Oesophageal cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013;24 Suppl 6:vi51-6. https://doi.org/10.1093/annonc/mdt342
  10. ClinicalTrial.gov. Neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for resectable locally advanced esophageal cancer (HCHTOG1903) [Internet]. Bethesda (MD): ClinicalTrial.gov; 2019 [cited 2020 Mar 20]. Available from: https://clinicaltrials.gov/ct2/show/NCT04138212.
  11. Lee J, Lee KE, Im YH, et al. Adjuvant chemotherapy with 5-fluorouracil and cisplatin in lymph node-positive thoracic esophageal squamous cell carcinoma. Ann Thorac Surg 2005;80:1170-5. https://doi.org/10.1016/j.athoracsur.2005.03.058
  12. Zhao P, Yan W, Fu H, Lin Y, Chen KN. Efficacy of postoperative adjuvant chemotherapy for esophageal squamous cell carcinoma: a meta- analysis. Thorac Cancer 2018;9:1048-55. https://doi.org/10.1111/1759-7714.12787
  13. Li Y, Zhao W, Ni J, et al. Predicting the value of adjuvant therapy in esophageal squamous cell carcinoma by combining the total number of examined lymph nodes with the positive lymph node ratio. Ann Surg Oncol 2019;26:2367-74. https://doi.org/10.1245/s10434-019-07489-3
  14. Lim SH, Shim YM, Park SH, et al. A randomized phase II study of leucovorin/5-fluorouracil with or without oxaliplatin (LV5FU2 vs. FOLFOX) for curatively-resected, node-positive esophageal squamous cell carcinoma. Cancer Res Treat 2017;49:816-23. https://doi.org/10.4143/crt.2016.417
  15. Burt BM, Groth SS, Sada YH, et al. Utility of adjuvant chemotherapy after neoadjuvant chemoradiation and esophagectomy for esophageal cancer. Ann Surg 2017;266:297-304. https://doi.org/10.1097/SLA.0000000000001954
  16. Kudo T, Hamamoto Y, Kato K, et al. Nivolumab treatment for oesophageal squamous-cell carcinoma: an open-label, multicentre, phase 2 trial. Lancet Oncol 2017;18:631-9. https://doi.org/10.1016/S1470-2045(17)30181-X
  17. Kato K, Cho BC, Takahashi M, et al. Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 2019;20:1506-17. https://doi.org/10.1016/s1470-2045(19)30626-6
  18. Metges J, Francois E, Shah M, et al. The phase 3 KEYNOTE-181 study: pembrolizumab versus chemotherapy as second-line therapy for advanced esophageal cancer. Ann Oncol 2019;30(Suppl_4):iv130. https://doi.org/10.1093/annonc/mdz154.011
  19. Antonia SJ, Villegas A, Daniel D, et al. Overall survival with durvalumab after chemoradiotherapy in stage III NSCLC. N Engl J Med 2018;379:2342-50. https://doi.org/10.1056/NEJMoa1809697
  20. ClinicalTrial.gov. Adjuvant durvalumab for esophageal cancer [Internet]. Bethesda (MD): ClinicalTrial.gov; 2019 [cited 2020 Mar 20]. Available from: https://clinicaltrials.gov/ct2/show/NCT02520453?term=jong-mu+sun&draw=2&rank=3.
  21. ClinicalTrial.gov. An investigational immuno-therapy study of nivolumab or placebo in participants with resected esophageal or gastroesophageal junction cancer (CheckMate 577) [Internet]. Bethesda (MD): ClinicalTrial.gov; 2020 [cited 2020 Mar 20]. Available from: https://clinicaltrials.gov/ct2/show/NCT02743494.