대한약침학회지 (Journal of Pharmacopuncture)

  • 제24권4호
  • /
  • Pages.191-195
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  • 2021
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  • 2093-6966(pISSN)
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  • 2234-6856(eISSN)
대한약침학회 (KOREAN PHARMACOPUNCTURE INSTITUTE)
권호 표지
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Chamomile Extract versus Clotrimazole Vaginal Cream in Treatment of Vulvovaginal Candidiasis: A Randomized Double-Blind Control Trial

  • Shiravani, Zahra (Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences) ;
  • Poordast, Tahereh (Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences) ;
  • Alamdarloo, Shaghayegh Moradi (Department of Perinatology, Maternal-fetal Medicine Research Center, Shiraz University of Medical Sciences) ;
  • Najib, Fateme sadat (Infertility Research Center, Department of Obstetrics and Gynecology, School of Medicine, Shiraz University of Medical Sciences) ;
  • Hosseinzadeh, Fatemeh (Department of Midwifery, School of Nursing and Midwifery, Estahban branch, Islamic Azad University) ;
  • Shahraki, Hadi Raeisi (Department of Epidemiology and Biostatistics, School of Health, Shahrekord University of Medical Sciences)
  • 투고 : 2020.09.22
  • 심사 : 2021.12.02
  • 발행 : 2021.12.31
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초록

Objectives: Vulvovaginal candidiasis (VVC) treatment is advised for all women due to its symptoms and complications. In this study, the standard treatment, clotrimazole, was compared with chamomile extract cream in outpatient clinics. Methods: We recruited 73 women with VVC, who were randomly allocated into two groups, clotrimazole versus chamomile extract cream. After two weeks of treatment with the same criteria, cheese-like vaginal discharge, itching and burning sensations, strawberry cervix, and recovery percentage was evaluated. Results: Thirty patients in each group were analyzed. There was no significant difference in age and number of pregnancies between groups (p = 0.85 and 0.09, respectively). Comparing before and after treatment, cheese like discharge (p < 0.001), itching (p < 0.001), burning (p < 0.001) had significantly improved in both groups. Further, the recovery percentage was not significantly different between groups (88.9% vs 75% in the chamomile vs clotrimazole groups, respectively). Conclusion: Chamomile is as effective as clotrimazole in VVC treatment; a higher percentage of women who used this medication recovered, although this did not reach significance. In addition, no complications were reported in either group.

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과제정보

The authors wish to thank Mr. H. Argasi at the Research Consultation Center (RCC) of Shiraz University of Medical Sciences for his invaluable assistance in editing this manuscript.

참고문헌

  1. Spence D. Candidiasis (vulvovaginal). BMJ Clin Evid. 2010;2010:0815.
  2. Sobel JD. Recurrent vulvovaginal candidiasis. Am J Obstet Gynecol. 2016;214(1):15-21. https://doi.org/10.1016/j.ajog.2015.06.067
  3. Dovnik A, Golle A, Novak D, Arko D, Takac I. Treatment of vulvovaginal candidiasis: a review of the literature. Acta Dermatovenerol Alp Pannonica Adriat. 2015;24(1):5-7.
  4. Cowen LE, Sanglard D, Howard SJ, Rogers PD, Perlin DS. Mechanisms of antifungal drug resistance. Cold Spring Harb Perspect Med. 2014;5(7):a019752.
  5. Zhou X, Li T, Fan S, Zhu Y, Liu X, Guo X, et al. The efficacy and safety of clotrimazole vaginal tablet vs. oral fluconazole in treating severe vulvovaginal candidiasis. Mycoses. 2016;59(7):419-28. https://doi.org/10.1111/myc.12485
  6. Satthakarn S, Hladik F, Promsong A, Nittayananta W. Vaginal innate immune mediators are modulated by a water extract of Houttuynia cordata Thunb. BMC Complement Altern Med. 2015;15:183. https://doi.org/10.1186/s12906-015-0701-9
  7. Ahangari F, Farshbaf-Khalili A, Javadzadeh Y, Adibpour M, Sadeghzadeh Oskouei B. Comparing the effectiveness of Salvia officinalis, clotrimazole and their combination on vulvovaginal candidiasis: a randomized, controlled clinical trial. J Obstet Gynaecol Res. 2019;45(4):897-907. https://doi.org/10.1111/jog.13918
  8. Miraj S, Alesaeidi S. A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile). Electron Physician. 2016;8(9):3024-31. https://doi.org/10.19082/3024
  9. Ghonime M, Eldomany R, Abdelaziz A, Soliman H. Evaluation of immunomodulatory effect of three herbal plants growing in Egypt. Immunopharmacol Immunotoxicol. 2011;33(1):141-5. https://doi.org/10.3109/08923973.2010.487490
  10. Lin TK, Zhong L, Santiago JL. Anti-inflammatory and skin barrier repair effects of topical application of some plant oils. Int J Mol Sci. 2017;19(1):70. https://doi.org/10.3390/ijms19010070
  11. Li W. Influence of nursing intervention on recurrent vulvovaginal candidiasis patients treated with ATP-infrared bio-effect technique. Iran J Public Health. 2018;47(10):1511-9.
  12. Tulasidas S, Rao P, Bhat S, Manipura R. A study on biofilm production and antifungal drug resistance among Candida species from vulvovaginal and bloodstream infections. Infect Drug Resist. 2018;11:2443-8. https://doi.org/10.2147/IDR.S179462
  13. Agusti G, Fittipaldi M, Morato J, Codony F. Viable quantitative PCR for assessing the response of Candida albicans to antifungal treatment. Appl Microbiol Biotechnol. 2013;97(1):341-9. https://doi.org/10.1007/s00253-012-4524-z
  14. Motealleh B, Zahedi P, Rezaeian I, Moghimi M, Abdolghaffari AH, Zarandi MA. Morphology, drug release, antibacterial, cell proliferation, and histology studies of chamomile-loaded wound dressing mats based on electrospun nanofibrous poly(ε-caprolactone)/polystyrene blends. J Biomed Mater Res B Appl Biomater. 2014;102(5):977-87. https://doi.org/10.1002/jbm.b.33078
  15. Ortiz-Bautista RJ, Garcia-Gonzalez LL, Ocadiz-Gonzalez MA, Flores-Tochihuitl J, Garcia-Villasenor A, Gonzalez-Hernandez M, et al. [Matricaria chamomilla (aqueous extract) improves atopic dermatitis-like lesions in a murine model]. Rev Med Inst Mex Seguro Soc. 2017;55(5):587-93. Spanish.