The Korean Journal of Physiology and Pharmacology

The Korean Society of Pharmacology (대한약리학회)
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The effect of adenosine triphosphate on propofol-induced myopathy in rats: a biochemical and histopathological evaluation

  • Erdem, Kezban Tuna Ozkaloglu (Balikesir Ataturk City Hospital Anesthesiology and Reanimation Clinic) ;
  • Bedir, Zehra (Department of Anesthesiology and Reanimation, Erzurum Nenehatun Maternity Hospital) ;
  • Ates, Irem (Department of Anesthesiology and Reanimation, Faculty of Medicine, Ataturk University) ;
  • Kuyrukluyildiz, Ufuk (Department of Anesthesiology and Reanimation, Erzincan Binali Yildirim University) ;
  • Coban, Taha Abdulkadir (Department of Medical Biochemistry, Erzincan Binali Yildirim University) ;
  • Yazici, Gulce Naz (Department of Histology and Embryology, Erzincan Binali Yildirim University) ;
  • Arslan, Yusuf Kemal (Department of Biostatistics, Faculty of Medicine, Erzincan Binali Yildirim University) ;
  • Suleyman, Zeynep (Department of Nursing, Faculty of Health Sciences, Erzincan Binali Yildirim University) ;
  • Suleyman, Halis (Department of Pharmacology, Faculty of Medicine, Erzincan Binali Yildirim University)
  • Received : 2020.07.29
  • Accepted : 2020.10.12
  • Published : 2021.01.01
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Abstract

Propofol infusion syndrome characterized by rhabdomyolysis, metabolic acidosis, kidney, and heart failure has been reported in long-term propofol use for sedation. It has been reported that intracellular adenosine triphosphate (ATP) is reduced in rhabdomyolysis. The study aims to investigate the protective effect of ATP against possible skeletal muscle damage of propofol in albino Wistar male rats biochemically and histopathologically. PA-50 (n = 6) and PA-100 (n = 6) groups of animals was injected intraperitoneally to 4 mg/kg ATP. An equal volume (0.5 ml) of distilled water was administered intraperitoneally to the P-50, P-100, and HG groups. One hour after the administration of ATP and distilled water, 50 mg/kg propofol was injected intraperitoneally to the P-50 and PA-50 groups. This procedure was repeated once a day for 30 days. The dose of 100 mg/kg propofol was injected intraperitoneally to the P-100 and PA-100 groups. This procedure was performed three times with an interval of 1 days. Our experimental results showed that propofol increased serum CK, CK-MB, creatinine, BUN, TP I, ALT, AST levels, and muscle tissue MDA levels at 100 mg/kg compared to 50 mg/kg and decreased tGSH levels. At a dose of 100 mg/kg, propofol caused more severe histopathological damage compared to 50 mg/kg. It was found that ATP prevented propofol-induced muscle damage and organ dysfunction at a dose of 50 mg/kg at a higher level compared to 100 mg/kg. ATP may be useful in the treatment of propofol-induced rhabdomyolysis and multiple organ damage.

Keywords

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