Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Review of Experimental Researches on Bee Venom Pharmacopuncture Therapy for Chemotherapy-induced Peripheral Neuropathy

항암화학요법 유발 말초신경병증에 대한 봉독 약침 요법의 효과 및 기전에 대한 실험연구 고찰

  • Kwon, Bo In (Department of Pathology, College of Korean Medicine, Sangji University) ;
  • Woo, Yeonju (Department of Physiology, College of Korean Medicine, Sangji University) ;
  • Kim, Joo-Hee (Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Sangji University)
  • 권보인 (상지대학교 한의과대학 병리학교실) ;
  • 우연주 (상지대학교 한의과대학 생리학교실) ;
  • 김주희 (상지대학교 한의과대학 침구의학교실)
  • Received : 2020.09.17
  • Accepted : 2021.02.10
  • Published : 2021.02.25
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Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most common dose-limiting side effects of neurotoxic chemotherapeutic agents that lead to decreased quality of life and dose reduction, delay or even cessation of treatment. The purpose of this systematic review is to evaluate the effect and the underlying mechanisms of bee venom (BV) pharmacopuncture therapy for CIPN in animal models. We searched for the available experimental literature using BV for CIPN through the Pubmed databases. Ten experimental studies were finally included in this review. In the oxaliplatin or paclitaxel-induced CIPN animal model, BV significantly relieved pain caused both mechanical and cold stimulation. It was suggested that the effect of BV is mediated by the stimulation effect of spinal α1- and α2-adrenergic receptors as a potential mechanism. In the future, more experimental studies are needed.

Keywords

References

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