Journal of Convergence Korean Medicine (대한융합한의학회지)

Academy of Convergence Korean Medicine (대한융합한의학회)
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Ovalbumin Induces Atopic Dermatitis-like Skin Lesions in Different Species of mice: pilot study

Ovalbumin으로 유도한 아토피성 피부염의 마우스 종별 차이에 관한 예비연구

  • Tae-Young Gil (Department of Pharmacology, College of Korean Medicine, Sangji University) ;
  • Bo-Ram Jin (Department of Pharmacology, College of Korean Medicine, Sangji University) ;
  • Hyo-Jin An (Department of Pharmacology, College of Korean Medicine, Sangji University)
  • 길태영 (상지대학교 한의과대학 약리학교실) ;
  • 진보람 (상지대학교 한의과대학 약리학교실) ;
  • 안효진 (상지대학교 한의과대학 약리학교실)
  • Received : 2021.07.02
  • Accepted : 2021.12.26
  • Published : 2021.12.31
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Abstract

Objectives: Atopic dermatitis (AD) is an easily recurrent inflammatory skin disease. Since AD has complex pathology, people have been investigating it on different aspects with various experimental models. One of them is in vivo model which has spontaneously developed AD-like skin lesions by various inducers. Methods: In this study, two kinds of mouse species were applied in the experiment; BALB/c and C57BL/6 mice. We compared features among the animal species making AD mouse model with protein allergen, ovalbumin. AD-like skin lesions were induced by ovalbumin on two kinds of scheme and were evaluated with the histological results and size of spleen which is a critical immunological organ. Also, we measured the level of immunoglobulin E in serum. In addition, we investigated the results of ovalbumin induced-AD-like skin lesions along with obesity. Results and Conclusion: We evaluated weight of organs and thickness of epidermis. These results suggest the possibility of the appropriate in vivo experimental model for AD or the comorbidity with obesity.

Keywords

Acknowledgement

This research was supported by Sangji university graduate school.

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