DOI QR코드

DOI QR Code

The Effects of Dietary Supplementation of Cysteamine Hydrochloride (CSH) on Growth Performance and Digestibility Characteristic in Broiler Chicks

Cysteamine hydrochloride (CSH)의 첨가 급여가 육용계의 생산성과 소화율에 미치는 영향

  • Seo, Kangmin (National Institute of Animal Science, Rural Development Administration) ;
  • Chun, Ju Lan (National Institute of Animal Science, Rural Development Administration) ;
  • Kim, Ki Hyun (National Institute of Animal Science, Rural Development Administration) ;
  • Nam, Ki-Taeg (Department of Animal Life and Environment Science, Hankyong National University)
  • 서강민 (농촌진흥청 국립축산과학원) ;
  • 천주란 (농촌진흥청 국립축산과학원) ;
  • 김기현 (농촌진흥청 국립축산과학원) ;
  • 남기택 (국립한경대학교 동물생명환경과학과)
  • Received : 2021.02.08
  • Accepted : 2021.05.07
  • Published : 2021.05.31

Abstract

This study investigated the effect of dietary supplementation with cysteamine hydrochloride (CSH) on the growth performance and nutrient digestibility of broilers. A total of 180 one-day-old male Ross broilers were allotted to one of the three treatment groups with three replications (20 birds per replication). The experimental groups were as follows: control group (basal diet), CSH-1 group (basal diet + 250 mg CSH/kg feed), and CSH-2 group (basal diet + 500 mg CSH/kg feed). During the grower period, feed intake, body weight, average daily gain, feed conversion ratio (FCR), and livability did not show any variation among the treatment groups. On the other hand, a comprehensive evaluation of the finisher period and the entire experiment period found that FCR was significantly improved in CSH-1 and CSH-2 groups as compared to the control group (p<0.05). The dietary supplementation of CSH did not affect the carcass and meat percent (breast and leg muscle). Although there was no significant difference, the digestibility of organic matter tended to be higher in the CSH-2 group than in the control group (p<0.1). This study suggests that a dietary supplement with 250-500 mg/kg CSH can be effective in improving FCR and the digestibility of organic matter in broilers.

본 연구는 Cysteamine hydrochloride (CSH)의 사료 내 첨가 급여가 육용계의 생산성 및 소화율에 미치는 영향을 조사하기 위해 수행되었다. 1 일령의 Ross broiler 수컷 180 수를 공시하여 3 개의 실험그룹에 각각 3 반복으로 반복 당 20 수씩 배치하였다. 실험설계는 Control (Basal diets), CSH-1 (Basal diets+250 mg CSH/kg feed), CSH-2 (Basal diets+500 mg CSH/kg feed)으로 디자인하였다. 육성 초기 동안의 일당 사료섭취량, 체중, 일당 증체량, 사료요구율, 육성률은 모든 실험그룹들 사이에서 차이가 나타나지 않았다. 육성 후기와 전체 실험기간 동안의 결과를 종합적으로 평가한 경우, CSH-1과 CSH-2 그룹은 Control 그룹과 비교하여 사료요구율이 유의하게 개선되는 것으로 나타났다(p<0.05). 한편, CSH의 사료 내 첨가는 육용계에 있어서 도체율과 정육률(가슴근육, 다리근육)에는 영향을 미치지 않는 것으로 나타났다. 유기물의 소화율은 CSH-2 그룹이 대조구에 비하여 높은 경향으로 나타났으나, 통계적인 유의차는 인정되지 않았다(p<0.1). 본 연구의 결과는 사료 내 250-500 mg/kg의 CSH 첨가 급여는 육용계의 사료요구율 및 유기물소화율을 개선시킬 수 있음을 시사한다.

Keywords

Acknowledgement

본 연구는 2020년도 농촌진흥청 국립축산과학원 전문연구원 지원사업에 의해 이루어진 것임.

References

  1. T. B. Stanton, "A call for antibiotic alternatives research", Trends in microbiology, Vol.21, No.3, pp.111-113, Mar. 2013. DOI: https://doi.org/10.1016/j.tim.2012.11.002
  2. J. S. Yoo, Y. J. Chen, I. H. Kim, "Effects of dietary complex probiotics on growth performance nutrient digestibility and blood characteristics in growing pigs", Journal of the Korea Academia-Industrial cooperation Society, Vol.8, No.5, pp.1266-1272, Oct. 2007.
  3. K. H. Kim, I. H. Song, J. L. Chun, J. H. Jeon, K. M. Seo, K. T. Nam, "Effects of dietary supplementation of condensed molasses soluble (CMS) on Growth Performance and Meat Quality in growing-finishing pigs", Journal of the Korea Academia-Industrial cooperation Society, Vol.21, No.11, pp.427-434, Nov. 2020. DOI: https://doi.org/10.5762/KAIS.2020.21.11.427
  4. K. H. Kim, J. Y. Jeong, I. H. Song, S. D. Lee, S. Y. Ji, Y. K. Lee, K. T. Nam, "Effects of dietary supplementation of enzyme complex on growth performance, carcass characteristics and meat storability in broiler chickens", Journal of the Korea Academia-Industrial cooperation Society, Vol.19, No.12, pp.740-748, Dec. 2018. DOI: https://doi.org/10.5762/KAIS.2018.19.12.740
  5. J. H. Cho, Y. J. Chen, B. J. Min, H. J. Kim, J. S. Yoo, T. G. Ko, Y. Hyun, I. H. Kim, "Effects of dietary herbal plant mixture (Koppuulv®) on growth performance, blood immunological parameters, fecal VFA and NH3-N concentrations in growing pigs", Journal of Animal Science and Technology, Vol.48, No.3, pp.375-282, Jun. 2006. DOI: https://doi.org/10.5187/JAST.2006.48.3.375
  6. M. C. Barnett, R. S. Hegarty, "Cysteamine: a human health dietary additive with potential to improve livestock growth rate and efficiency", Animal Production Science, Vol.56, No.8, pp.1330-1338, Jun. 2016. DOI: http://dx.doi.org/10.1071/AN15339
  7. J. O. Nunes, A. G. Bertechini, J. A. G. D. Brito, L. Makiyama, F. R. Mesquita, C. M. Nishio, "Evaluation of cysteamine associated with different energy patterns in diets for broiler chickens", Revista Brasileira de Zootecnia, Vol.41, No.8, pp.1956-1960, Jun. 2012. DOI: https://doi.org/10.1590/S1516-35982012000800022
  8. M. R. Brown, L. A. Fisher, P. E. Sawchenko, L. W. Swanson, W. W. Vale, "Biological effects of cysteamine: relationship to somatostatin depletion", Regulatory peptides, Vol.5, No.2, pp.163-179, Jan. 1983. DOI: https://doi.org/10.1016/0167-0115(83)90124-6
  9. S. Reichlin, "Somatostatin", new england Journal of Medicine, Vol.309, No.24, pp.1495-1501, Jan. 1983. DOI: https://doi.org/10.1056/NEJM198312153092406
  10. C. H. S. McIntosh, "Gastrointestinal somatostatin: distribution, secretion and physiological significance", Life sciences, Vol.37, No.22, pp.2043-2058, Dec. 1985. DOI: https://doi.org/10.1016/0024-3205(85)90576-4
  11. Y. Miyamoto, M. Miyamoto, "Immunohistochemical localizations of secretin, cholecystokinin, and somatostatin in the rat small intestine after acute cisplatin treatment", Experimental and molecular pathology, Vol.77, No.3, pp.238-245, Dec. 2004. DOI: https://doi.org/10.1016/j.yexmp.2004.05.007
  12. W. J. Millard, In animal growth regulation: Central regulation of growth hormone secretion, p.400, Springer, 1989, pp.237-255.
  13. J. M. M. Rondeel, I. M. D. Jackson, "Molecular biology of the regulation of hypothalamic hormones", Journal of endocrinological investigation, Vol.16, No.3, pp.219-246, Mar. 1993. DOI: http://dx.doi.org/10.1007/BF03344952
  14. J. Morisset, "Negative control of human pancreatic secretion: Physiological mechanisms and factor", Pancreas, Vol.37, No.1, pp.1-12, Jul. 2008. DOI: https://doi.org/10.1097/MPA.0b013e318161b99a
  15. J. Morisset, "One of the rare multifunctional inhibitors of mammalian species", Pancreas, Vol.46, No.1, pp.8-18, Jan. 2017. DOI: https://doi.org/10.1097/mpa.0000000000000716
  16. M. C. Aguila, W. L. Dees, W. E. Haensly, S. M. McCann, "Evidence that somatostatin is localized and synthesized in lymphoid organs", Proceedings of the National Academy of Sciences, Vol.88, No.24, pp.11485-11489, Dec. 1991. DOI: https://doi.org/10.1073/pnas.88.24.11485
  17. P. M. Van Hagen, "Somatostatin receptor expression in clinical immunology", Metabolism, Vol.45, No.1 pp.86-87, Aug. 1996. DOI: https://doi.org/10.1016/S0026-0495(96)90092-X
  18. D. Xiao, H. R. Lin, "Cysteamine a somatostatin inhibiting agent-induced growth hormone secretion and growth acceleration in juvenile grass carp (Ctenopharyngodon idellus)", General and Comparative Endocrinology, Vol.134, No.4, pp.285-295, Dec. 2003. DOI: https://doi.org/10.1016/S0016-6480(03)00268-5
  19. W. W. Wardani, A. Alimuddin, M. Zairin Jr, M. Setiawati, S. Nuryati, M. A. Suprayudi, "Evaluation of cysteamine supplementation in red tilapia (Oreochromis sp.) diet: Serum insulin and somatostatin, IGF-1 and GLUT4 genes expression, growth performance, and robustness against stress", Aquaculture, Vol.528, No.15, 735514, Nov. 2020. DOI: https://doi.org/10.1016/j.aquaculture.2020.735514
  20. C. B. Yang, A. K. Li, Y. L. Yin, R. L. Huang, T. J. Li, L. L. Li, M. Z. Fan, "Effects of dietary supplementation of cysteamine on growth performance, carcass quality, serum hormones and gastric ulcer in finishing pigs", Journal of the Science of Food and Agriculture, Vol.85, No.11, pp.1947-1952, May. 2005. DOI: https://doi.org/10.1002/jsfa.2123
  21. P. Zhou, L. Zhang, J. Li, Y. Luo, B. Zhang, S. Xing, Y. Zhu, H. Sun, F. Gao, G. Zhou, "Effects of dietary crude protein levels and cysteamine supplementation on protein synthetic and degradative signaling in skeletal muscle of finishing pigs", PLoS One, Vol.10, No.9, e0139393, Sept. 2015. DOI: https://doi.org/10.1371/journal.pone.0139393
  22. C. Wang, C. J. Dong, Z. Q. Wang, F. Yang, H. L. Mao, Z. Wu, Q. Zhou, H. F. Wang, "Effect of cysteamine hydrochloride supplementation on the milk performance of dairy cow", Livestock Science, Vol.17, pp.94-99, Aug. 2015. DOI: https://doi.org/10.1016/j.livsci.2015.05.005
  23. Y. Hu, Y. Ni, L. Ren, J. Dai, R. Zhao, "Leptin is involved in the effects of cysteamine on egg laying of hens, characteristics of eggs, and posthatch growth of broiler offspring", Poultry Science, Vol.87, No.9, pp.1810-1817, Sep. 2008. DOI: https://doi.org/10.3382/ps.2008-00040
  24. C. M. Yang, A. G. Chen, Q. H. Hong, J. X. Liu, J. S. Liu, "Effects of cysteamine on growth performance, digestive enzyme activities, and metabolic hormones in broilers", Poultry science, Vol.85, No.11, pp.1912-1916, Nov. 2006. DOI: https://doi.org/10.1093/ps/85.11.1912
  25. Q. Yang, G. Lian, X. Gong, "Enhancement of mucosal immune responses in chickens by oral administration of cysteamine", Poultry science, Vol.86, No.7, pp.1323-1328, Jul. 2007. DOI: https://doi.org/10.1093/ps/86.7.1323
  26. N. Liu, L. Lin, J. Wang, F. Zhang, J. P. Wang, "Dietary cysteamine hydrochloride protects against oxidation, inflammation, and mucosal barrier disruption of broiler chickens challenged with Clostridium perfringens", Journal of animal science, Vol.96, No.10, pp.4339-2347, Oct. 2018a. DOI: https://doi.org/10.1093/jas/sky292
  27. N. Liu, J. Q. Wang, Z. Y.. Liu, Y. K. Chen, J. P. Wang, "Effect of cysteamine hydrochloride supplementation on the growth performance, enterotoxic status, and glutathione turnover of broilers fed aflatoxin B1 contaminated diets", Poultry science, Vol.97, No.10, pp.3594-3600, Oct. 2018b. DOI: https://doi.org/10.3382/ps/pey206
  28. M. T. Zavy, T. O. Lindsey, "Effect of cysteamine administration on growth and efficiency of food utilisation in chicks", British poultry science, Vol.29, No.2, pp.409-417, Nov. 1988. DOI: https://doi.org/10.1080/00071668808417066
  29. Aviagen, Ross broiler management manual, p.147, Online Publishers: www.aviagen.com 2018, p.131-132.
  30. P. Cunniff, AOAC international. Official methods of analysis of AOAC International. 16th ed. p.448, AOAC International, 1995, pp.382-382
  31. G. S. Spencer, "New approach to regulation of growth using immunization against somatostatin: discussion paper", Journal of the Royal Society of Medicine, Vol.77, No.6, pp.496-500, Jun. 1984. https://doi.org/10.1177/014107688407700611
  32. T. R. Hall, S. Harvey, C. G. Scanes, "Control of growth hormone secretion in the vertebrates: a comparative survey", Comparative Biochemistry and Physiology Part A: Physiology, Vol.84, No.2, pp.231-253, 1986. DOI: https://doi.org/10.1016/0300-9629(86)90608-0
  33. X. J. Ai, Z. K. Han, "Effect of cysteamine on the pancreatic secretion and lipase activity of geese", Acta Universitatis Agriculturalis Boreali-occidentalis, Vol.30, No.4, pp.105-108, Jan. 2002.