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Observational Study of the Treatment of 116 Cases of High Risk Group for Dementia and Depression in Multiple Korean Medicine Clinic

치매 및 우울증 고위험군 116례의 한의 치료에 대한 관찰 연구

  • Received : 2021.03.02
  • Accepted : 2021.06.23
  • Published : 2021.06.25

Abstract

In order to reduce the social and economic costs due to the increase in dementia patients, which is a representative senile disease in an aging society, it will be important to prevent dementia and to detect and treat early in high-risk groups. This study reported the results of treatment for the elderly with high risk of dementia and depression who received Korean medicine (KM) treatment in 9 KM clinics. Medical charts were surveyed on 116 patients with high risk of dementia and depression who received KM treatment at 9 KM clinics in Gangseo-gu from September 1, 2020 to December 31, 2020. The majority of the patients were female(76.72%), the average age was 71.66±7.18 years old, and the average education level was 8.96±3.91 years. The average treatment period was 61.47±10.30 days, the average number of treatments was 15.38±1.06 times, and both acupuncture and herbal medicine were administered. After receiving KM treatment, cognitive assessment scores such as MMSE-DS and MoCA-K, depression-related GDSSF-K score, dementia knowledge, attitude, and preventive behavior, blood debilitation scale, and GQOL-D score were improved compared to before. There was no specific adverse reaction except that one patient with elevated AST and ALT levels was observed. This study showed improvement in cognitive function, depression, dementia-related scale, and quality of life in high-risk groups for dementia and depression over 60 years old who received KM treatment. More systematic and large-scale planned clinical studies will be needed.

Keywords

References

  1. Central Dementia Center. Korean Dementia observatory 2019. 2019. Available at: https://www.nid.or.kr/info/dataroom_view.aspx?bid=209.
  2. Park UJ. Trends analysis of characteristics in patient with dementia. Journal of the Korea Academia-Industrial cooperation Society. 2017;18(1):202-9. https://doi.org/10.5762/KAIS.2017.18.1.202
  3. Relkin N. Screening and early diagnosis of dementia. Am J Manag Care. 2000;6 (22):S1111-8.
  4. Jorm AF, Dear KB, Burgess NM. Projections of future numbers of dementia cases in Australia with and without prevention. Aust N Z J Psychiatry. 2005;39(11-12):959-63. https://doi.org/10.1080/j.1440-1614.2005.01713.x
  5. Lee SD, Lee EK, Park YR, Jung MS, Park HM, et al. Final Report on development of a health promotion program for Korean medicine for the elderly. 2015.
  6. OECD. OECD Health Policy Studies: Addressing Dementia: Improving the lives of people living with dementia. 2015. https://doi.org/10.1787/9789264231726-6-en
  7. GKOM, The Korean Society of Oriental Neuropsychiatry. Korean Medicine Clinical Practice Guideline for Dementia. 2017.
  8. Kang HW, Jung IC, Jung SY. Report on the results of the diagnosis of dementia by Korean medical method. 2014.
  9. The Korean Society of Oriental Neuropsychiatry Textbook Compilation Commmittee. Oriental Neuropsychiatry. Seoul : Jipmoondang. 2010. p. 333-42.
  10. Choi Y, Kim YE, Jerng UM, Kim H, Lee SI, Kim GN, et al. Korean Traditional Medicine in Treating Patients with Mild Cognitive Impairment: a multicenter prospective observational case series. Evidence-Based Complementary and Alternative Medicine, 2020:2020.
  11. Seoul metropolitan government. 2018 Elderly Korean Medicine Health Promotion Project Business Guide and Standard Manual. 2018.
  12. Kim GW, Kim MH, Kim BJ, Kim JR, Kim TH, Moon SW, et al. Final report of the "Standardization of Dementia Diagnosis Tools" research project. 2009.
  13. Kee BS. A preliminary study for the standardization of geriatric depression scale short form-Korea version. J Korean Neuropsychiatr Assoc. 1996;35(2):298-307.
  14. Jo MJ, Kim GW, Kim MH, Kim MD, Kim BJ, Kim SK, et al. Final Report of the Dementia Prevalence Survey Project. 2008.
  15. Lee YW. The Effect of Dementia Education on the Changes in Dementia Knowledge, Attitude, and Preventive Behavior of Middle-aged Low-Income Women. Annual Report for Namgu Dementia Caring Center. Incheon. 2007.
  16. Jang SJ. The Effect of Social Capital and Social Support on Behavioral Intention of Dementia Prevention : Regulation Effect of Family Strengths as the Cultural Characteristic of Korea. Ewha Womans University Graduate School. 2014.
  17. Lee GE, Moon KS, Kim NK, Chung SY, Jung IC, Kang HW. Preliminary Study to Develop the Korean Medical Pathologic Aging Scale and Korean Medical Pattern Identification for Dementia. J Korean Med. 2017;38(3):111-23. https://doi.org/10.13048/jkm.17030
  18. Hur J. Donguibogam. Seoul:Namsandang, 2007.
  19. Lee JY, Lee DW, Cho SJ, Na DL, Jeon HJ, Kim SK, et al. Brief screening for mild cognitive impairment in elderly outpatient clinic: validation of the Korean version of the Montreal Cognitive Assessment, Journal of geriatric psychiatry and neurology. 2008;21(2):104-10. https://doi.org/10.1177/0891988708316855
  20. Lee HS, Kim JH, Ko HJ, Ku HM, Kwon EJ, Shin JY, et al. The Standardization of the Ge riatric Quality of Life s cale-Dementia (GQOL-D). Journal of the Korean Geriatrics Society. 2004;8(3):151-64.
  21. Oh BH. Diagnosis and Treatment for Behavioral and Psychological Symptoms of Dementia. Journal of the Korean Medical Association. 2009;52(11):1048-54.
  22. Morris JC, Rubin EH, Morris EJ, Mandel SA. Senile dementia of the Alzheimer's type: an important risk factor for serious falls. J Gerontol. 1987;42:412-7. https://doi.org/10.1093/geronj/42.4.412
  23. Kim GB. Current status and prospects of the elderly with dementia. The Korean Nurse. 1998;37:16-24.
  24. Kwon JD. What to do with dementia?. Daejeon Branch of the Korean Dementia Family Association. 2002.
  25. Rovner BW, Broadhead J, Spencer M, Carson K, Folstein MF. Depresion and Alzheimer's disease. American Journal of Psychiatry,. 1989;46:350-3.
  26. Na YM, Kim HJ, Ha YR, Lee SS, Ko UH, Son GC. Application and practice of horticultural therapy. Seoul: Seowon, 1999. p. 149-55.
  27. Jung CI, Kim YS, Lee HW, Kim GC. The effect of cooking and art activities on cognitive function and depression of dementia patients. The Journal of the Korean Medicine Diagnostics. 2011;15(1):67-76.
  28. Kang HC. A study on comparison of Yangseng (traditional health behavior), depression, anxiety and cognitive function between the elderly women living alone and the aged in the living with family. Journal of Oriental Neuropsychiatry. 2014;25(2):123-32. https://doi.org/10.7231/jon.2014.25.2.123
  29. Chae KS. Effects of the Laughing and Music Therapy on the Depression and Activities of Autonomic Nervous System for Elderly with Dementia. Hanyang University. 2013.
  30. Seo EH. Neuropsychological assessment of dementia and cognitive disorders. J Korean Neuropsychiatr Assoc 2018;57(1):2-11. https://doi.org/10.4306/jknpa.2018.57.1.2
  31. Yoo JE. Recent changes and challenges in national dementia policy in Korea. In Health Welf. Policy Forum. 2019;276:6-18.
  32. Kim DH, Sakong JW, Kang CW, Lee SH, Ha JW, Kim BK. A study on homogeneity analysis of the Guipi decoction for treatment of insomnia disorder-focusing on randomized controlled clinical trials in CNKI. Journal of Oriental Neuropsychiatry. 2018;29(3):145-63. https://doi.org/10.7231/JON.2018.29.3.145
  33. Lee SH, Jang SR, Kim DC. A Case Report of Patient with Psychogenic Tremor Treated with Gagamguibi-tang gamibang. The Journal of East-West Medicine. 2016;41(3):19-28.
  34. Kim JW, Kim SJ. The enhancing effects of Gwibi-tang (guipi-tang) on cognitive function and memory in scopolamine-induced dementia rat model. Oriental Rehabilitation Med. 2012;22(3):1-14.
  35. Tohda C, Naito R, Joyashiki E. Kihi-to, a herbal traditional medicine, improves Abeta (25-35)-induced memory impairment and losses of neurites and synapses. BMC Complementary and Alternative Medicine. 2008;8(1):1-21. https://doi.org/10.1186/1472-6882-8-1
  36. Watari H, Shimada Y, Matsui M, Tohda C. Kihito, a traditional Japanese kampo medicine, improves cognitive function in Alzheimer's disease patients. Evidence-Based Complementary and Alternative Medicine. 2019:2019.
  37. Moon SY, Jerng UM, Kwon OJ, Jung SY, Lee JY, Yoon SW, et al. Comparative Effectiveness of Cheonwangbosimdan (Tian Wang Bu Xin Dan) Versus Cognitive-Behavioral Therapy for Insomnia in Cancer Patients: A Randomized, Controlled, Open-Label, Parallel-Group, Pilot Trial. Integrative Cancer Therapies. 2020;19:1534735420935643.
  38. Seoul metropolitan government. Elderly Korean Medicine Health Promotion Project Results Report. Available at: https://opengov.seoul.go.kr/sanction/17471270
  39. Seoul metropolitan government. 2019 Elderly Korean Medicine Health Promotion Project Results Report. Available at: https://opengov.seoul.go.kr/sanction/19872433
  40. Lee MR. Dementia Knowledge, Attitude and Preventive behaviors of Middle-aged Adults. Journal of Digital Convergence. 2019;7(12):383-91.
  41. Yang JI, Lee KH, Kim YS, Shin MK, Yoo JH, Chang GT. A report on liver function tests of 82 psoriasis patients taking herbal medication over 3 months. The Journal of Korean Medicine. 2012;33(3):95-104.
  42. Yun YJ, Shin BC, Lee MS, Cho SI, Shin WJ, Park HJ, et al. Korean herbal medicine on liver function: A systematic review in korean literature. The Journal of Internal Korean Medicine. 2009;30(1):153-72.
  43. Park YC, Park HM, Lee SD. Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medecines in a View of Toxicology. J Korean Oriental Med. 2011;32(4):55-63.
  44. Jang IS, Yang CS, Lee SD, Han CH. A Review of Herbal Medicinal Products Associated with Toxic Events in Korea. J Korean Oriental Med. 2007;28(1):3-7.