Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Perilla Frutescens Extract Protects against Scopolamine-Induced Memory Deficits in Mice

스코폴라민으로 유도한 기억력 손상 모델에서 소엽 추출물의 보호 효과

  • Lee, Jihye (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Lee, Eunhong (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Jung, Eun Mi (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University) ;
  • Kim, Dong Hyun (Department of Pharmacology, School of Medicine, Konkuk University) ;
  • Kim, Sung-kyu (SFC bio) ;
  • Park, Mi Hee (SFC bio) ;
  • Jung, Ji Wook (Division of Bio-technology and Convergence, College of Herbal Bio-Industry, Daegu Haany University)
  • 이지혜 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 이은홍 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 정은미 (대구한의대학교 바이오산업대학 바이오산업융합학부) ;
  • 김동현 (건국대학교 의과대학 약리학교실) ;
  • 김성규 ((주)에스에프씨바이오) ;
  • 박미희 ((주)에스에프씨바이오) ;
  • 정지욱 (대구한의대학교 바이오산업대학 바이오산업융합학부)
  • Received : 2021.02.18
  • Accepted : 2021.05.25
  • Published : 2021.06.25
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Abstract

Perilla frutescens (P. frutescens) is an important herb used for many purposes such as medicinal, aromatic, and functional food in Asian countries and has beneficial effects such as antioxidant activity, anti-inflammation activity, anti-depression activity, and anxiolytic activity. However, there have been no studies on the protective effect of P. frutescens extract (PFE) on amnesia in vivo. The present study aimed to investigate whether PFE protects memory deficit using a scopolamine-induced mice model and elucidate the underlying mechanisms involved. The protective effect of PFE against scopolamine-induced memory deficits was investigated using Y-maze, passive avoidance, and Morris water maze tests. Furthermore, the potential mechanisms of PFE in improving memory capabilities related to the cholinergic system and antioxidant activity were examined. PFE significantly increased spontaneous alternation in the Y-maze test, step-through latency in the passive avoidance test, and swimming time in the target quadrant in the probe test when compared to the scopolamine-treated group. Likewise, PFE significantly decreased escapes latency in the Morris water maze test. PFE could not regulate cholinergic function in acetylcholine level and acetylcholine esterase activity. However, PFE increased DPPH radical scavenging activity dose-dependently and total polyphenol content was 127.7±1.2 ㎍ GAE/mg. The results showed that the PFE could be a preventive and/or therapeutic candidate for memory and cognitive dysfunction in Alzheimer's disease.

Keywords

Acknowledgement

본 성과물은 한국식품산업클러스터진흥원의 지원에 의해 이루어진 것입니다.

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