The Korean Journal of Physiology and Pharmacology

  • 제25권5호
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  • Pages.489-494
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  • 2021
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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5-HT1A receptors mediate the analgesic effect of rosavin in a mouse model of oxaliplatin-induced peripheral neuropathic pain

  • Li, Daxian (Department of Physiology, College of Korean Medicine, Kyung Hee University) ;
  • Park, Sangwon (Department of Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Kyungjoon (Department of East-West Medicine, Graduate School, Kyung Hee University) ;
  • Jang, Dae Sik (Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University) ;
  • Kim, Sun Kwang (Department of Physiology, College of Korean Medicine, Kyung Hee University)
  • 투고 : 2021.04.19
  • 심사 : 2021.06.21
  • 발행 : 2021.09.01
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초록

Oxaliplatin, a third-generation platinum derivative, is the mainstay of current antineoplastic medications for advanced colorectal cancer therapy. However, peripheral neuropathic complications, especially cold allodynia, undermine the life-prolonging outcome of this anti-cancer agent. Rosavin, a phenylpropanoid derived originally from Rhodiola rosea, exhibits a wide range of therapeutic properties. The present study explored whether and how rosavin alleviates oxaliplatin-induced cold hypersensitivity in mice. In the acetone drop test, cold allodynia behavior was observed from days 3 to 5 after a single injection of oxaliplatin (6 mg/kg, i.p.). Cold allodynia was significantly attenuated following rosavin treatment (10 mg/kg, i.p.). Specific endogenous 5-HT depletion by three consecutive pretreatments with parachlorophenylalanine (150 mg/kg/day, i.p.) abolished the analgesic action of rosavin; this effect was not observed following pretreatment with naloxone (opioid receptor antagonist, 10 mg/kg, i.p.). Furthermore, 5-HT1A receptor antagonist WAY-100635 (0.16 mg/kg, i.p.), but not 5-HT3 receptor antagonist MDL-72222 (1 mg/kg, i.p.), blocked rosavin-induced analgesia. These results suggest that rosavin may provide a novel approach to alleviate oxaliplatin-induced cold allodynia by recruiting the activity of 5-HT1A receptors.

키워드

과제정보

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (NRF-2017M3A9E4057926).

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