The Korean Journal of Physiology and Pharmacology

  • 제25권5호
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  • Pages.413-423
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  • 2021
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  • 1226-4512(pISSN)
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  • 2093-3827(eISSN)
대한약리학회 (The Korean Society of Pharmacology)
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Curcumin attenuates renal ischemia reperfusion injury via JNK pathway with the involvement of p300/CBP-mediated histone acetylation

  • Yang, Lu (Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University) ;
  • Chen, Xiaoxiang (Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University) ;
  • Bi, Zirong (Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University) ;
  • Liao, Jun (Department of Organ Transplantation, Zhujiang Hospital of Southern Medical University) ;
  • Zhao, Weian (Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University) ;
  • Huang, Wenqi (Department of Anesthesiology, The First Affiliated Hospital of Sun Yat-sen University)
  • 투고 : 2021.02.15
  • 심사 : 2021.06.11
  • 발행 : 2021.09.01
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초록

Apoptosis is proved responsible for renal damage during ischemia/reperfusion. The regulation for renal apoptosis induced by ischemia/reperfusion injury (IRI) has still been unclearly characterized to date. In the present study, we investigated the regulation of histone acetylation on IRI-induced renal apoptosis and the molecular mechanisms in rats with the application of curcumin possessing a variety of biological activities involving inhibition of apoptosis. Sprague-Dawley rats were randomized into four experimental groups (SHAM, IRI, curcumin, SP600125). Results showed that curcumin significantly decreased renal apoptosis and caspase-3/-9 expression and enhanced renal function in IRI rats. Treatment with curcumin in IRI rats also led to the decrease in expression of p300/cyclic AMP response element-binding protein (CBP) and activity of histone acetyltransferases (HATs). Reduced histone H3 lysine 9 (H3K9) acetylation was found near the promoter region of caspase-3/-9 after curcumin treatment. In a similar way, SP600125, an inhibitor of c-Jun N-terminal kinase (JNK), also attenuated renal apoptosis and enhanced renal function in IRI rats. In addition, SP600125 suppressed the binding level of p300/CBP and H3K9 acetylation near the promoter region of caspase-3/-9, and curcumin could inhibit JNK phosphorylation like SP600125. These results indicate that curcumin could attenuate renal IRI via JNK/p300/CBP-mediated anti-apoptosis signaling.

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과제정보

This study was supported by research grants from National Natural Science Foundation of China (Grant No. 81770619).

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