Animal Bioscience

Asian Australasian Association of Animal Production Societies (아세아태평양축산학회)
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Stillbirth rates and their association with swine leucocyte antigen class II haplotypes in Microminipigs

  • Imaeda, Noriaki (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Ando, Asako (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Matsubara, Tatsuya (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Takasu, Masaki (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Nishii, Naohito (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University) ;
  • Miyamoto, Asuka (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Ohshima, Shino (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Kametani, Yoshie (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Suzuki, Shingo (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Shiina, Takashi (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Ono, Tetsushi (Department of Veterinary Medicine, Faculty of Veterinary Medicine, Okayama University of Science) ;
  • Kulski, Jerzy K. (Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, Tokai University School of Medicine) ;
  • Kitagawa, Hitoshi (Department of Veterinary Medicine, Faculty of Applied Biological Sciences, Gifu University)
  • Received : 2020.11.09
  • Accepted : 2021.05.11
  • Published : 2021.11.01
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Abstract

Objective: Microminipig (MMP) is a miniature pig with an extra small body size for experimental use. In the present study, the occurrence of stillbirths and their genetic association with swine leukocyte antigen (SLA) class II haplotypes were evaluated in a population of MMPs. Methods: The occurrences of stillbirth and genetic association with SLA class II haplotypes using 483 stillborn and 2,246 live piglets, and their parents were compared among the three groups of newborn piglet litters; an all stillborn (AS) group consisting of only stillborn piglet litters, a partial stillborn (PS) group consisting of stillborn and live piglet litters, and an all alive (AA) group consisting of only live piglet litters. Results: The incidence of stillborn piglets was 483/2,729 (17.7%). Distributions of litter sizes, numbers of stillborn piglets in a litter, parities, and gestation periods were distinct among the three groups. The frequencies of low resolution haplotype (Lr)-0.7 or Lr-0.23 were higher in the AS group than in the PS or AA groups. In sires, the frequency of Lr-0.7 associated with the AS group was significantly higher in the AS group than with the AA group. In dams, the frequency of Lr-0.23 was significantly higher in the AS group than in the PS or AA groups, whereas the frequency of Lr-0.7 was not significantly different. Conclusion: The incidence of stillborn piglets in MMPs appears to be higher than those in other pig breeds. Several traits related with stillbirths such as the number of stillborn piglets and parities of the AS group were different from those of the PS and AA groups. Specific SLA class II haplotypes were associated significantly with a high incidence of stillbirths and could be used as genetic markers to adopt breeding strategies to lower the rate of stillbirth in MMPs.

Keywords

Acknowledgement

We would like to thank Mr. Takashi Nishimura and Mr. Toshiyuki Nishimura, Fuji Micra Inc., for sampling and providing the breeding records.

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