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Korea Information Electronic Communication Technology (한국정보전자통신기술학회)
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Review : Effectiveness of transcranial direct current stimulation in rodent models of Alzheimer's disease

알츠하이머병 쥐 모델에서 경두개 직류 전기자극의 효용성 검토

  • Kim, Ji-Eun (Department of Neurology, Gangneung Asan Hospital, University of Ulsan College of Medicine) ;
  • Park, Ye-Eun (Department of Biomedical Engineering, Catholic Kwandong University) ;
  • Jeong, Jin-Hyoung (Department of Biomedical IT, Catholic Kwandong University) ;
  • Lee, Sang-Sik (Department of Biomedical Engineering, Catholic Kwandong University)
  • Received : 2021.09.17
  • Accepted : 2021.10.25
  • Published : 2021.10.30
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Abstract

Alzheimer's disease (AD) is the most common cause of dementia, showing progressive neurodegeneration. Although oral medications for symptomatic improvement still take a huge part of treatment, there are several limitations caused by pharmacology-based real world clinic. In this respect, non-pharmacologic treatment for AD is rising to prominence. Transcranial direct current stimulation (tDCS) is a one of the non-invasive neuromodulation technique, using low-voltage direct current. In terms of safety, tDCS already has been proven through numerous previous reports. This review focused on behavioral, neurophysiologic and histopathologic improvement by applying tDCS in AD rodent models, thereby suggesting reliable background evidence for human-based tDCS study.

알츠하이머병은 치매를 일으키는 원인 중 가장 높은 빈도를 차지하는 신경퇴행성 질환으로서, 아직은 증상을 개선시키는 정도의 약물적 치료가 주를 이룬다. 이러한 경구약제의 치료적 한계성 및 신약개발의 어려움에 직면하여 임상에서는 비약물적 치료에 대한 관심이 높아지고 있다. 경두개 직류전기자극(transcranial direct current stimulation, tDCS)는 낮은 강도의 직류전류를 이용한 비침습적 뇌조절술의 한 종류로서, 그 안전성에 대해서는 이미 널리 입증받은 바 있다. 본 종설에서는 알츠하이머병 쥐 모델에게 tDCS를 적용함으로써 얻을 수 있는 행동학적, 신경생리학적, 뇌조직학적 회복에 대한 객관적 근거들을 살펴봄으로써, 인간 대상 tDCS연구의 배경근거를 제시하고자 한다.

Keywords

Acknowledgement

This research was supported by the first research project of the National Research Foundation of Korea (NRF-2020R1G1A1103054).

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